Imperial College London

Dr Paul Edison, MD, PhD, MPhil, FRCP, FRCPI

Faculty of MedicineDepartment of Brain Sciences

Clinical Senior Lecturer
 
 
 
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Contact

 

paul.edison

 
 
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Location

 

2S 5A, Level 2Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

199 results found

Edison P, 2022, Brain Connectivity:<p> A Journal of Clinical Neurology and Neuroscience</p>, BRAIN CONNECTIVITY, Vol: 12, Pages: 109-111, ISSN: 2158-0014

Journal article

Young M, Crook H, Scott J, Edison Pet al., 2022, Covid-19: virology, variants, and vaccines, BMJ Medicine, Vol: 1, Pages: e000040-e000040

<jats:p>As of 25 January 2022, over 349 million individuals have received a confirmed diagnosis of covid-19, with over 5.59 million confirmed deaths associated with the SARS-CoV-2 virus. The covid-19 pandemic has prompted an extensive global effort to study the molecular evolution of the virus and develop vaccines to prevent its spread. Although rigorous determination of SARS-CoV-2 infectivity remains elusive, owing to the continuous evolution of the virus, steps have been made to understand its genome, structure, and emerging genetic mutations. The SARS-CoV-2 genome is composed of several open reading frames and structural proteins, including the spike protein, which is essential for entry into host cells. As of 25 January 2022, the World Health Organization has reported five variants of concern, two variants of interest, and three variants under monitoring. Additional sublineages have since been identified, and are being monitored. The mutations harboured in these variants confer an increased transmissibility, severity of disease, and escape from neutralising antibodies compared with the primary strain. The current vaccine strategy, including booster doses, provides protection from severe disease. As of 24 January 2022, 33 vaccines have been approved for use in 197 countries. In this review, we discuss the genetics, structure, and transmission methods of SARS-CoV-2 and its variants, highlighting how mutations provide enhanced abilities to spread and inflict disease. This review also outlines the vaccines currently in use around the world, providing evidence for every vaccine's immunogenicity and effectiveness.</jats:p>

Journal article

Livingston NR, Calsolaro V, Hinz R, Nowell J, Raza S, Gentleman S, Tyacke RJ, Myers J, Venkataraman AV, Perneczky R, Gunn RN, Rabiner EA, Parker CA, Murphy PS, Wren PB, Nutt DJ, Matthews PM, Edison Pet al., 2022, Relationship between astrocyte reactivity, using novel C-11-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals, MOLECULAR PSYCHIATRY, ISSN: 1359-4184

Journal article

Edison P, 2022, Brain Connectivity: A Comprehensive Journal in Clinical Neurology and Neuroscience, BRAIN CONNECTIVITY, Vol: 12, Pages: 3-5, ISSN: 2158-0014

Journal article

Edison P, 2022, Call for Papers: Brain Connectivity., Brain Connect, Vol: 12

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Edison P, 2022, Call for Papers: Brain Connectivity., Brain Connect

Journal article

Edison P, 2021, COVID-19, Network Dysfunction and Neurodegeneration, BRAIN CONNECTIVITY, Vol: 11, Pages: 785-787, ISSN: 2158-0014

Journal article

Leng F, Hinz R, Gentleman S, Brooks DJ, Edison Pet al., 2021, Neuroinflammation, functional connectivity and structural network integrity in the Alzheimer's spectrum, Alzheimer's &amp; dementia : the journal of the Alzheimer's Association, Vol: 17

BACKGROUND: To investigate whether neuroinflammation and β-amyloid (Aβ) deposition influence brain structural and functional connectivity in Alzheimer's spectrum, we conducted a cross-sectional multimodal imaging study and interrogated the associations between imaging biomarkers of neuroinflammation, Aβ deposition, brain connectivity and cognition. METHOD: 58 participants (25 MCI, 16 AD dementia and 17 healthy controls) were recruited and scanned with 11 C-PBR28 and 18 F-flutemetamol PET, T1-weighted, diffusion tensor and resting-state functional MRI. Brain structural and functional connectivity were assessed by global white matter integrity and functional topology metrics, while neuroinflammation and Aβ deposition were evaluated by 11 C-PBR28 and 18 F-flutemetamol uptake, respectively. Changes of the biomarkers were compared between diagnostic groups and robust regression analyses at both voxel and regional level were performed on Aβ positive patients, who were considered to be representative of Alzheimer's continuum. RESULT: Increased 11 C-PBR28 and 18 F-flutemetamol uptake, decreased FA values, impaired small-worldness and local efficiency of functional network were observed in the AD cohort. In Aβ-positive patients, cortical 11 C-PBR28 uptake correlated with decreased structural integrity and network local efficiency independent of 18 F-flutemetamol uptake and cortical thickness. Network structural integrity and cortical thickness correlated with functional metrics, including small-worldness and local efficiency, which were all associated with cognition. CONCLUSION: Our findings suggest that cortical neuroinflammation may lead to disruption of structural and functional brain network independent of amyloid deposition and cortical atrophy, which in turn can lead to cognitive impairment in AD.

Journal article

Edison P, 2021, Call for Papers: Brain Connectivity., Brain Connect, Vol: 11

Journal article

Edison P, 2021, Brain Connectivity: Evaluating Neurological Complications in COVID-19, BRAIN CONNECTIVITY, Vol: 11, Pages: 692-694, ISSN: 2158-0014

Journal article

Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy J-P, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto Pet al., 2021, Publisher Correction: Microglial activation and tau propagate jointly across Braak stages., Nat Med, Vol: 27, Pages: 2048-2049

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Edison P, 2021, Brain Connectivity:& nbsp;Advancing Neuroscience and Neuroimaging, BRAIN CONNECTIVITY, Vol: 11, Pages: 596-598, ISSN: 2158-0014

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Edison P, 2021, Call for Papers: Brain Connectivity, BRAIN CONNECTIVITY, Vol: 11, Pages: 595-595, ISSN: 2158-0014

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Edison P, 2021, Brain Connectivity: Advances in Neuroimaging to Investigate COVID-19, BRAIN CONNECTIVITY, Vol: 11, Pages: 502-504, ISSN: 2158-0014

Journal article

Edison P, 2021, Call for Papers: Brain Connectivity., Brain Connect, Vol: 11

Journal article

Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Scholl M, de Leon MJ, Soucy J-P, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto Pet al., 2021, Microglial activation and tau propagate jointly across Braak stages, NATURE MEDICINE, Vol: 27, Pages: 1592-+, ISSN: 1078-8956

Journal article

Edison P, 2021, Brain Connectivity: Neuronal Damage in COVID-19, BRAIN CONNECTIVITY, Vol: 11, Pages: 405-407, ISSN: 2158-0014

Journal article

Crook H, Raza S, Nowell J, Young M, Edison Pet al., 2021, Long covid-mechanisms, risk factors, and management., BMJ, Vol: 374, Pages: 1-18, ISSN: 1759-2151

Since its emergence in Wuhan, China, covid-19 has spread and had a profound effect on the lives and health of people around the globe. As of 4 July 2021, more than 183 million confirmed cases of covid-19 had been recorded worldwide, and 3.97 million deaths. Recent evidence has shown that a range of persistent symptoms can remain long after the acute SARS-CoV-2 infection, and this condition is now coined long covid by recognized research institutes. Studies have shown that long covid can affect the whole spectrum of people with covid-19, from those with very mild acute disease to the most severe forms. Like acute covid-19, long covid can involve multiple organs and can affect many systems including, but not limited to, the respiratory, cardiovascular, neurological, gastrointestinal, and musculoskeletal systems. The symptoms of long covid include fatigue, dyspnea, cardiac abnormalities, cognitive impairment, sleep disturbances, symptoms of post-traumatic stress disorder, muscle pain, concentration problems, and headache. This review summarizes studies of the long term effects of covid-19 in hospitalized and non-hospitalized patients and describes the persistent symptoms they endure. Risk factors for acute covid-19 and long covid and possible therapeutic options are also discussed.

Journal article

Calsolaro V, Matthews PM, Donat CK, Livingston NR, Femminella GD, Guedes SS, Myers J, Fan Z, Tyacke RJ, Venkataraman AV, Perneczky R, Gunn R, Rabiner EA, Gentleman S, Parker CA, Murphy PS, Wren PB, Hinz R, Sastre M, Nutt DJ, Edison Pet al., 2021, Astrocyte reactivity with late onset cognitive impairment assessed in-vivo using 11C-BU99008 PET and its relationship with amyloid load, Molecular Psychiatry, Vol: 26, Pages: 5848-5855, ISSN: 1359-4184

11C-BU99008 is a novel positron emission tomography (PET) tracer that enables selective imaging of astrocyte reactivity in vivo. To explore astrocyte reactivity associated with Alzheimer’s disease, 11 older, cognitively impaired (CI) subjects and 9 age-matched healthy controls (HC) underwent 3T magnetic resonance imaging (MRI), 18F-florbetaben and 11C-BU99008 PET. The 8 amyloid (Aβ)-positive CI subjects had higher 11C-BU99008 uptake relative to HC across the whole brain, but particularly in frontal, temporal, medial temporal and occipital lobes. Biological parametric mapping demonstrated a positive voxel-wise neuroanatomical correlation between 11C-BU99008 and 18F-florbetaben. Autoradiography using 3H-BU99008 with post-mortem Alzheimer’s brains confirmed through visual assessment that increased 3H-BU99008 binding localised with the astrocyte protein glial fibrillary acid protein and was not displaced by PiB or florbetaben. This proof-of-concept study provides direct evidence that 11C-BU99008 can measure in vivo astrocyte reactivity in people with late-life cognitive impairment and Alzheimer’s disease. Our results confirm that increased astrocyte reactivity is found particularly in cortical regions with high Aβ load. Future studies now can explore how clinical expression of disease varies with astrocyte reactivity.

Journal article

Edison P, Mallon DH, 2021, The role of amyloid PET in patient selection for extra-ventricular shunt insertion for the treatment of idiopathic normal pressure hydroephalus: A pooled analysis ., Journal of Clinical Neuroscience, ISSN: 0967-5868

Journal article

Edison P, 2021, Microglial activation and blood-brain barrier leakage: chicken and egg?, Brain, Vol: 144, Pages: 1284-1285

Journal article

Mallon DH, Malhotra P, Naik M, Edison P, Perry R, Carswell C, Win Zet al., 2021, The role of amyloid PET in patient selection for extra-ventricular shunt insertion for the treatment of idiopathic normal pressure hydrocephalus: A pooled analysis, JOURNAL OF CLINICAL NEUROSCIENCE, Vol: 90, Pages: 325-331, ISSN: 0967-5868

Journal article

Alagaratnam J, von Widekind S, De Francesco D, Underwood J, Edison P, Winston A, Zetterberg H, Fidler Set al., 2021, Correlation between CSF and blood neurofilament light chain protein: A systematic review and meta-analysis, BMJ Open Neurology, Vol: 3, ISSN: 2632-6140

Objective To assess the overall pooled correlation coefficient estimate between cerebrospinal fluid (CSF) and blood neurofilament light (NfL) protein.Methods We searched Medline, Embase and Web of Science for published articles, from their inception to 9 July 2019, according to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Studies reporting the correlation between CSF and blood NfL in humans were included. We conducted a random-effects meta-analysis to calculate the overall pooled correlation coefficient estimate, accounting for correlation technique and assay used. Heterogeneity was assessed using the I2 statistic test. In sensitivity analyses, we calculated the pooled correlation coefficient estimate according to blood NfL assay: single-molecule array digital immunoassay (Simoa), electrochemiluminescence (ECL) assay or ELISA.Results Data were extracted from 36 articles, including 3961 paired CSF and blood NfL samples. Overall, 26/36 studies measured blood NfL using Simoa, 8/36 ECL, 1/36 ELISA and 1 study reported all three assay results. The overall meta-analysis demonstrated that the pooled correlation coefficient estimate for CSF and blood NfL was r=0.72. Heterogeneity was significant: I2=83%, p<0.01. In sensitivity analyses, the pooled correlation coefficient was similar for studies measuring blood NfL using Simoa and ECL (r=0.69 and r=0.68, respectively) but weaker for ELISA (r=0.35).Conclusion Moderate correlations are demonstrated between CSF and blood NfL, especially when blood NfL was measured using Simoa and ECL. Given its high analytical sensitivity, Simoa is the preferred assay for measuring NfL, especially at low or physiological concentrations, and this meta-analysis supports its use as the current most advanced surrogate measure of CSF NfL.PROSPERO registration number CRD42019140469

Journal article

Edison P, 2021, Brain Connectivity and Neurological Sequalae in COVID-19, BRAIN CONNECTIVITY, Vol: 11, Pages: 331-332, ISSN: 2158-0014

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Edison P, 2021, Brain Connectivity and Neurological Sequalee in COVID-19, Brain Connectivity

Journal article

Edison P, 2021, Microglial activation and blood-brain barrier leakage: chicken and egg?, Brain

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Edison P, 2021, Brain Connectivity and COVID-19, BRAIN CONNECTIVITY, Vol: 11, Pages: 251-252, ISSN: 2158-0014

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Edison P, 2021, Brain Connectivity and COVID-19, Brain Connectivity, ISSN: 2158-0014

Journal article

Edison P, 2021, Brain Connectivity and Alzheimer's Disease, Brain Connectivity, ISSN: 2158-0014

Journal article

Edison P, 2021, Brain Connectivity and Alzheimer's Disease, BRAIN CONNECTIVITY, Vol: 11, Pages: 157-158, ISSN: 2158-0014

Journal article

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

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