Imperial College London

Dr Paul Edison, MD, PhD, MPhil, FRCP, FRCPI

Faculty of MedicineDepartment of Brain Sciences

Clinical Reader
 
 
 
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Contact

 

paul.edison

 
 
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Location

 

2S 5A, Level 2Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

212 results found

Pasqualetti G, Thayanandan T, Edison P, 2022, Influence of genetic and cardiometabolic risk factors in Alzheimer?s disease, AGEING RESEARCH REVIEWS, Vol: 81, ISSN: 1568-1637

Journal article

Nowell J, Blunt E, Edison P, 2022, Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease, MOLECULAR PSYCHIATRY, ISSN: 1359-4184

Journal article

Edison P, 2022, Brain Connectivity: A Journal of Clinical Neurology, Neuroscience, and Neuroimaging Advancing the Field of Neurology, BRAIN CONNECTIVITY, Vol: 12, Pages: 683-685, ISSN: 2158-0014

Journal article

Edison P, 2022, Brain Connectivity: A Journal of Clinical Neurology, Neuroscience, and Neuroimaging Advancing the Field of Neurology, BRAIN CONNECTIVITY, Vol: 12, Pages: 599-601, ISSN: 2158-0014

Journal article

Mohamed MA, Zeng Z, Gennaro M, Lao-Kaim N, Myers J, Calsolaro V, Femminella G, Tyacke R, Martin-Bastida A, Gunn R, Nutt D, Edison P, Piccini P, Roussakis Aet al., 2022, Astrogliosis in aging and Parkinson’s disease dementia: a new clinical study with 11C-BU99008 PET, Brain Communications, Vol: 4, ISSN: 2632-1297

The role of astrogliosis in the pathology of brain aging and neurodegenerative diseases has recently drawn great attention. Imidazoline-2 binding sites (I2BS) represent a possible target to map the distribution of reactive astrocytes. In this study, we use 11C-BU99008, an I2BS-specific PET radioligand, to image reactive astrocytes in vivo in healthy controls (HCs) andpatients with established Parkinson’s disease dementia (PDD).Eighteen HCs (age: 45−78 years) and six patients with PDD (age: 64−77 years) had one 11C-BU99008 PET-CT scan with arterial input function. All subjects underwent one 3T MRI brain scan to facilitate the analysis of the PET-CT data and to capture individual cerebral atrophy. Regional 11C-BU99008 volumes of distribution (VT) were calculated for each subject by two-tissue compartmental modelling.Positive correlations between 11C-BU99008 VT values and age were found for all tested regions across the brain within HCs (p<0.05); furthermore, multiple regression indicated that aging affects 11C-BU99008 VT values in a region-specific manner. Independent samples t-test indicated that there was no significant group difference in 11C-BU99008 VT values betweenPDD (n=6; mean age = 71.97±4.66 years) and older HCs (n=9; mean age = 71.90±5.51 years).Our dataset shows that astrogliosis is common with aging in a region-specific manner. However, in this set-up, 11C-BU99008 PET cannot differentiate patients with PDD from healthy controls of similar age.

Journal article

Edison P, 2022, Brain Connectivity: A Journal of Clinical Neurology, Neuroscience, and Neuroimaging, BRAIN CONNECTIVITY, Vol: 12, Pages: 498-501, ISSN: 2158-0014

Journal article

Loreto F, Fitzgerald A, Golemme M, Gunning S, Win Z, Patel N, Carswell C, Perry R, Kennedy A, Edison P, Malhotra Pet al., 2022, Prevalence of depressive symptoms in a memory clinic cohort: a retrospective study, Journal of Alzheimer's Disease, Vol: 88, ISSN: 1387-2877

Background Depression has been suggested to be a cause of reversible cognitive impairment but also a risk factor for neurodegenerative disease. Studies suggest that depression prevalence may be high in early onset dementia, particularly Alzheimer’s disease, but this has not been systematically assessed in a biomarker-validated clinical dementia cohort to date. Objective To examine the prevalence, features and association with amyloid pathology of lifetime depressive symptoms in a memory clinic cohort meeting appropriate use criteria for amyloid PET imaging.Methods We included 300 patients from a single-centre memory clinic cohort that received diagnostic biomarker evaluation with amyloid PET imaging according to appropriate use criteria. History of lifetime depressive symptoms was retrospectively assessed through structured review of clinical correspondence. Results One-hundred-and-forty-two (47%) patients had a history of significant depressive symptoms (‘D+’). Of these, 89% had ongoing symptoms and 60% were on antidepressants at the time of presentation to our Clinic. Depressive symptoms were equally highly prevalent in the amyloid-positive and the heterogeneous group of amyloid-negative patients.Conclusions Approximately half of patients who meet appropriate use criteria for amyloid PET had a history of depressive symptoms. We suggest that depression is an important feature of both neurodegenerative and non-neurodegenerative cognitive impairment and may contribute to the diagnostic uncertainty behind referral to amyloid PET.

Journal article

Edison P, 2022, Brain Connectivity???????: A Journal of Clinical Neurology and Neuroscience, BRAIN CONNECTIVITY, Vol: 12, Pages: 299-301, ISSN: 2158-0014

Journal article

Edison P, 2022, Brain Connectivity: A Clinical Neurology and Neuroscience Journal, BRAIN CONNECTIVITY, Vol: 12, Pages: 207-209, ISSN: 2158-0014

Journal article

Edison P, 2022, Brain Connectivity: A Journal of Clinical Neurology and Neuroscience, BRAIN CONNECTIVITY, Vol: 12, Pages: 109-111, ISSN: 2158-0014

Journal article

Young M, Crook H, Scott J, Edison Pet al., 2022, Covid-19: virology, variants, and vaccines, BMJ Medicine, Vol: 1, Pages: e000040-e000040

<jats:p>As of 25 January 2022, over 349 million individuals have received a confirmed diagnosis of covid-19, with over 5.59 million confirmed deaths associated with the SARS-CoV-2 virus. The covid-19 pandemic has prompted an extensive global effort to study the molecular evolution of the virus and develop vaccines to prevent its spread. Although rigorous determination of SARS-CoV-2 infectivity remains elusive, owing to the continuous evolution of the virus, steps have been made to understand its genome, structure, and emerging genetic mutations. The SARS-CoV-2 genome is composed of several open reading frames and structural proteins, including the spike protein, which is essential for entry into host cells. As of 25 January 2022, the World Health Organization has reported five variants of concern, two variants of interest, and three variants under monitoring. Additional sublineages have since been identified, and are being monitored. The mutations harboured in these variants confer an increased transmissibility, severity of disease, and escape from neutralising antibodies compared with the primary strain. The current vaccine strategy, including booster doses, provides protection from severe disease. As of 24 January 2022, 33 vaccines have been approved for use in 197 countries. In this review, we discuss the genetics, structure, and transmission methods of SARS-CoV-2 and its variants, highlighting how mutations provide enhanced abilities to spread and inflict disease. This review also outlines the vaccines currently in use around the world, providing evidence for every vaccine's immunogenicity and effectiveness.</jats:p>

Journal article

Livingston NR, Calsolaro V, Hinz R, Nowell J, Raza S, Gentleman S, Tyacke RJ, Myers J, Venkataraman AV, Perneczky R, Gunn RN, Rabiner EA, Parker CA, Murphy PS, Wren PB, Nutt DJ, Matthews PM, Edison Pet al., 2022, Relationship between astrocyte reactivity, using novel C-11-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals, MOLECULAR PSYCHIATRY, Vol: 27, Pages: 2019-2029, ISSN: 1359-4184

Journal article

Edison P, 2022, Brain Connectivity: A Comprehensive Journal in Clinical Neurology and Neuroscience, BRAIN CONNECTIVITY, Vol: 12, Pages: 3-5, ISSN: 2158-0014

Journal article

Edison P, 2022, Call for Papers: Brain Connectivity., Brain Connect, Vol: 12

Journal article

Edison P, 2022, Call for Papers: Brain Connectivity., Brain Connect

Journal article

Leng F, Zhan Z, Sun Y, Liu F, Edison P, Sun Y, Wang Zet al., 2022, Cerebrospinal Fluid sTREM2 Has Paradoxical Association with Brain Structural Damage Rate in Early- and Late-Stage Alzheimer's Disease, JOURNAL OF ALZHEIMERS DISEASE, Vol: 88, Pages: 117-126, ISSN: 1387-2877

Journal article

de Erausquin GA, Snyder H, Brugha TS, Seshadri S, Carrillo M, Sagar R, Huang Y, Newton C, Tartaglia C, Teunissen C, Hakanson K, Akinyemi R, Prasad K, D'Avossa G, Gonzalez-Aleman G, Hosseini A, Vavougios GD, Sachdev P, Bankart J, Mors NPO, Lipton R, Katz M, Fox PT, Katshu MZ, Iyengar MS, Weinstein G, Sohrabi HR, Jenkins R, Stein DJ, Hugon J, Mavreas V, Blangero J, Cruchaga C, Krishna M, Wadoo O, Becerra R, Zwir I, Longstreth WT, Kroenenberg G, Edison P, Mukaetova-Ladinska E, Staufenberg E, Figueredo-Aguiar M, Yecora A, Vaca F, Zamponi HP, Lo Re V, Majid A, Sundarakumar J, Gonzalez HM, Geerlings M, Skoog I, Salmoiraghi A, Boneschi FM, Patel VN, Santos JM, Rivera Arroyo G, Caballero Moreno A, Felix P, Gallo C, Arai H, Yamada M, Iwatsubo T, Sharma M, Chakraborty N, Ferreccio C, Akena D, Brayne C, Maestre G, Blangero SW, Brusco L, Siddarth P, Hughes TM, Zuniga AR, Kambeitz J, Laza AR, Allen N, Panos S, Merrill D, Ibanez A, Tsuang D, Valishvili N, Shrestha S, Wang S, Padma V, Anstey KJ, Ravindrdanath V, Blennow K, Mullins P, Pria A, Mosley TH, Gowland P, Girard TD, Bowtell R, Vahidy FSet al., 2022, Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium, ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, Vol: 8

Journal article

Edison P, 2021, COVID-19, Network Dysfunction and Neurodegeneration, BRAIN CONNECTIVITY, Vol: 11, Pages: 785-787, ISSN: 2158-0014

Journal article

Leng F, Hinz R, Gentleman S, Brooks DJ, Edison Pet al., 2021, Neuroinflammation, functional connectivity and structural network integrity in the Alzheimer's spectrum, Alzheimer's &amp; dementia : the journal of the Alzheimer's Association, Vol: 17

BACKGROUND: To investigate whether neuroinflammation and β-amyloid (Aβ) deposition influence brain structural and functional connectivity in Alzheimer's spectrum, we conducted a cross-sectional multimodal imaging study and interrogated the associations between imaging biomarkers of neuroinflammation, Aβ deposition, brain connectivity and cognition. METHOD: 58 participants (25 MCI, 16 AD dementia and 17 healthy controls) were recruited and scanned with 11 C-PBR28 and 18 F-flutemetamol PET, T1-weighted, diffusion tensor and resting-state functional MRI. Brain structural and functional connectivity were assessed by global white matter integrity and functional topology metrics, while neuroinflammation and Aβ deposition were evaluated by 11 C-PBR28 and 18 F-flutemetamol uptake, respectively. Changes of the biomarkers were compared between diagnostic groups and robust regression analyses at both voxel and regional level were performed on Aβ positive patients, who were considered to be representative of Alzheimer's continuum. RESULT: Increased 11 C-PBR28 and 18 F-flutemetamol uptake, decreased FA values, impaired small-worldness and local efficiency of functional network were observed in the AD cohort. In Aβ-positive patients, cortical 11 C-PBR28 uptake correlated with decreased structural integrity and network local efficiency independent of 18 F-flutemetamol uptake and cortical thickness. Network structural integrity and cortical thickness correlated with functional metrics, including small-worldness and local efficiency, which were all associated with cognition. CONCLUSION: Our findings suggest that cortical neuroinflammation may lead to disruption of structural and functional brain network independent of amyloid deposition and cortical atrophy, which in turn can lead to cognitive impairment in AD.

Journal article

Edison P, 2021, Call for Papers: Brain Connectivity., Brain Connect, Vol: 11

Journal article

Edison P, 2021, In vivo assessment of astroglial activation in cognitively impaired subjects using C-11-BU99008 PET and its relationship with amyloid load, Publisher: SAGE PUBLICATIONS INC, Pages: 66-66, ISSN: 0271-678X

Conference paper

Edison P, 2021, Brain Connectivity: Evaluating Neurological Complications in COVID-19, BRAIN CONNECTIVITY, Vol: 11, Pages: 692-694, ISSN: 2158-0014

Journal article

Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy J-P, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto Pet al., 2021, Publisher Correction: Microglial activation and tau propagate jointly across Braak stages., Nat Med, Vol: 27, Pages: 2048-2049

Journal article

Edison P, 2021, Brain Connectivity: Advancing Neuroscience and Neuroimaging, BRAIN CONNECTIVITY, Vol: 11, Pages: 596-598, ISSN: 2158-0014

Journal article

Edison P, 2021, Call for Papers: Brain Connectivity, BRAIN CONNECTIVITY, Vol: 11, Pages: 595-595, ISSN: 2158-0014

Journal article

Edison P, 2021, Brain Connectivity: Advances in Neuroimaging to Investigate COVID-19, BRAIN CONNECTIVITY, Vol: 11, Pages: 502-504, ISSN: 2158-0014

Journal article

Edison P, 2021, Call for Papers: Brain Connectivity., Brain Connect, Vol: 11

Journal article

Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Scholl M, de Leon MJ, Soucy J-P, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto Pet al., 2021, Microglial activation and tau propagate jointly across Braak stages, NATURE MEDICINE, Vol: 27, Pages: 1592-+, ISSN: 1078-8956

Journal article

Edison P, 2021, Brain Connectivity: Neuronal Damage in COVID-19, BRAIN CONNECTIVITY, Vol: 11, Pages: 405-407, ISSN: 2158-0014

Journal article

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