Imperial College London
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Professor Paul Edison

Faculty of Medicine, Department of Brain Sciences

Professor of Neuroscience
 
 
 
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Contact

 

paul.edison

 
 
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Location

 

2S 5A, Level 2Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Leng:2021:10.1002/alz.055970,
author = {Leng, F and Hinz, R and Gentleman, S and Brooks, DJ and Edison, P},
doi = {10.1002/alz.055970},
journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},
title = {Neuroinflammation, functional connectivity and structural network integrity in the Alzheimer's spectrum},
url = {http://dx.doi.org/10.1002/alz.055970},
volume = {17},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: To investigate whether neuroinflammation and β-amyloid (Aβ) deposition influence brain structural and functional connectivity in Alzheimer's spectrum, we conducted a cross-sectional multimodal imaging study and interrogated the associations between imaging biomarkers of neuroinflammation, Aβ deposition, brain connectivity and cognition. METHOD: 58 participants (25 MCI, 16 AD dementia and 17 healthy controls) were recruited and scanned with 11 C-PBR28 and 18 F-flutemetamol PET, T1-weighted, diffusion tensor and resting-state functional MRI. Brain structural and functional connectivity were assessed by global white matter integrity and functional topology metrics, while neuroinflammation and Aβ deposition were evaluated by 11 C-PBR28 and 18 F-flutemetamol uptake, respectively. Changes of the biomarkers were compared between diagnostic groups and robust regression analyses at both voxel and regional level were performed on Aβ positive patients, who were considered to be representative of Alzheimer's continuum. RESULT: Increased 11 C-PBR28 and 18 F-flutemetamol uptake, decreased FA values, impaired small-worldness and local efficiency of functional network were observed in the AD cohort. In Aβ-positive patients, cortical 11 C-PBR28 uptake correlated with decreased structural integrity and network local efficiency independent of 18 F-flutemetamol uptake and cortical thickness. Network structural integrity and cortical thickness correlated with functional metrics, including small-worldness and local efficiency, which were all associated with cognition. CONCLUSION: Our findings suggest that cortical neuroinflammation may lead to disruption of structural and functional brain network independent of amyloid deposition and cortical atrophy, which in turn can lead to cognitive impairment in AD.
AU  - Leng,F
AU  - Hinz,R
AU  - Gentleman,S
AU  - Brooks,DJ
AU  - Edison,P
DO  - 10.1002/alz.055970
PY  - 2021///
TI  - Neuroinflammation, functional connectivity and structural network integrity in the Alzheimer's spectrum
T2  - Alzheimer's & dementia : the journal of the Alzheimer's Association
UR  - http://dx.doi.org/10.1002/alz.055970
VL  - 17
ER  -
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