Imperial College London
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DrPaulExpert

Faculty of Medicine, School of Public Health

Honorary Research Associate
 
 
 
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Contact

 

paul.expert08

 
 
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Location

 

Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pandit:2013:10.1212/WNL.0b013e3182929f38,
author = {Pandit, AS and Expert, P and Lambiotte, R and Bonnelle, V and Leech, R and Turkheimer, FE and Sharp, DJ},
doi = {10.1212/WNL.0b013e3182929f38},
journal = {NEUROLOGY},
pages = {1826--1833},
title = {Traumatic brain injury impairs small-world topology},
url = {http://dx.doi.org/10.1212/WNL.0b013e3182929f38},
volume = {80},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: We test the hypothesis that brain networks associated with cognitive function shift away from a “small-world” organization following traumatic brain injury (TBI).Methods: We investigated 20 TBI patients and 21 age-matched controls. Resting-state functional MRI was used to study functional connectivity. Graph theoretical analysis was then applied to partial correlation matrices derived from these data. The presence of white matter damage was quantified using diffusion tensor imaging.Results: Patients showed characteristic cognitive impairments as well as evidence of damage to white matter tracts. Compared to controls, the graph analysis showed reduced overall connectivity, longer average path lengths, and reduced network efficiency. A particular impact of TBI is seen on a major network hub, the posterior cingulate cortex. Taken together, these results confirm that a network critical to cognitive function shows a shift away from small-world characteristics.Conclusions: We provide evidence that key brain networks involved in supporting cognitive function become less small-world in their organization after TBI. This is likely to be the result of diffuse white matter damage, and may be an important factor in producing cognitive impairment after TBI.
AU  - Pandit,AS
AU  - Expert,P
AU  - Lambiotte,R
AU  - Bonnelle,V
AU  - Leech,R
AU  - Turkheimer,FE
AU  - Sharp,DJ
DO  - 10.1212/WNL.0b013e3182929f38
EP  - 1833
PY  - 2013///
SN  - 0028-3878
SP  - 1826
TI  - Traumatic brain injury impairs small-world topology
T2  - NEUROLOGY
UR  - http://dx.doi.org/10.1212/WNL.0b013e3182929f38
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319251000007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/62075
VL  - 80
ER  -
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