Imperial College London
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DrPaulExpert

Faculty of Medicine, School of Public Health

Honorary Research Associate
 
 
 
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Contact

 

paul.expert08

 
 
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Location

 

Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lord:2016:10.3389/fnsys.2016.00085,
author = {Lord, L-D and Expert, P and Fernandes, HM and Petri, G and Van, Hartevelt TJ and Vaccarino, F and Deco, G and Turkheimer, F and Kringelbach, ML},
doi = {10.3389/fnsys.2016.00085},
journal = {FRONTIERS IN SYSTEMS NEUROSCIENCE},
title = {Insights into Brain Architectures from the Homological Scaffolds of Functional Connectivity Networks},
url = {http://dx.doi.org/10.3389/fnsys.2016.00085},
volume = {10},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In recent years, the application of network analysis to neuroimaging data has provided useful insights about the brain's functional and structural organization in both health and disease. This has proven a significant paradigm shift from the study of individual brain regions in isolation. Graph-based models of the brain consist of vertices, which represent distinct brain areas, and edges which encode the presence (or absence) of a structural or functional relationship between each pair of vertices. By definition, any graph metric will be defined upon this dyadic representation of the brain activity. It is however unclear to what extent these dyadic relationships can capture the brain's complex functional architecture and the encoding of information in distributed networks. Moreover, because network representations of global brain activity are derived from measures that have a continuous response (i.e., interregional BOLD signals), it is methodologically complex to characterize the architecture of functional networks using traditional graph-based approaches. In the present study, we investigate the relationship between standard network metrics computed from dyadic interactions in a functional network, and a metric defined on the persistence homological scaffold of the network, which is a summary of the persistent homology structure of resting-state fMRI data. The persistence homological scaffold is a summary network that differs in important ways from the standard network representations of functional neuroimaging data: (i) it is constructed using the information from all edge weights comprised in the original network without applying an ad hoc threshold and (ii) as a summary of persistent homology, it considers the contributions of simplicial structures to the network organization rather than dyadic edge-vertices interactions. We investigated the information domain captured by the persistence homological scaffold by computing the strength of each node in the scaffol
AU  - Lord,L-D
AU  - Expert,P
AU  - Fernandes,HM
AU  - Petri,G
AU  - Van,Hartevelt TJ
AU  - Vaccarino,F
AU  - Deco,G
AU  - Turkheimer,F
AU  - Kringelbach,ML
DO  - 10.3389/fnsys.2016.00085
PY  - 2016///
SN  - 1662-5137
TI  - Insights into Brain Architectures from the Homological Scaffolds of Functional Connectivity Networks
T2  - FRONTIERS IN SYSTEMS NEUROSCIENCE
UR  - http://dx.doi.org/10.3389/fnsys.2016.00085
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387491400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/62076
VL  - 10
ER  -
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