Imperial College London

ProfessorPaulFrench

Faculty of Natural SciencesDepartment of Physics

Professor of Physics and Vice Dean (Research) - FoNS
 
 
 
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Contact

 

+44 (0)20 7594 7706paul.french Website

 
 
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Assistant

 

Ms Judith Baylis +44 (0)20 7594 7713

 
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Location

 

609Blackett LaboratorySouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Van:2017:10.1016/j.celrep.2017.01.010,
author = {Van, de Pette M and Abbas, A and Feytout, A and McNamara, G and Bruno, L and To, WK and Dimond, A and Sardini, A and Webster, Z and McGinty, J and Paul, EJ and Ungless, MA and French, PMW and Withers, DJ and Uren, A and Ferguson-Smith, AC and Merkenschlager, M and John, RM and Fisher, AG},
doi = {10.1016/j.celrep.2017.01.010},
journal = {Cell Reports},
pages = {1090--1099},
title = {Visualizing changes in Cdkn1c expression links early life adversity to imprint mis-regulation in adults},
url = {http://dx.doi.org/10.1016/j.celrep.2017.01.010},
volume = {31},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Imprinted genes are regulated according to parental origin and can influence embryonic growth and metabolism and confer disease susceptibility.Here we designed sensitive allele-specific reporters to non-invasively monitor imprinted Cdkn1cexpression in mice and showed that expression was modulated by environmental factors encounteredin utero.Acute exposure to chromatin modifyingdrugs resulted in de-repression of paternally inherited (silent) Cdkn1calleles in embryos that was temporary and resolved after birth.In contrast, deprivation of maternal dietary proteinin uteroprovoked permanent de-repression of imprinted Cdkn1cexpression that was sustained into adulthood and occurred through a folate-dependent mechanism of DNA methylation loss.Given the function of imprinted genes in regulating behavior and metabolic processes in adults, these results establish imprinting deregulation as a credible mechanism linking early life adversity to later-life outcomes.Furthermore,Cdkn1c-luciferasemice offer non-invasivetools to identify factors that disrupt epigenetic processes and strategies to limit their long-term impact.
AU - Van,de Pette M
AU - Abbas,A
AU - Feytout,A
AU - McNamara,G
AU - Bruno,L
AU - To,WK
AU - Dimond,A
AU - Sardini,A
AU - Webster,Z
AU - McGinty,J
AU - Paul,EJ
AU - Ungless,MA
AU - French,PMW
AU - Withers,DJ
AU - Uren,A
AU - Ferguson-Smith,AC
AU - Merkenschlager,M
AU - John,RM
AU - Fisher,AG
DO - 10.1016/j.celrep.2017.01.010
EP - 1099
PY - 2017///
SN - 2211-1247
SP - 1090
TI - Visualizing changes in Cdkn1c expression links early life adversity to imprint mis-regulation in adults
T2 - Cell Reports
UR - http://dx.doi.org/10.1016/j.celrep.2017.01.010
UR - http://hdl.handle.net/10044/1/43828
VL - 31
ER -