Imperial College London
Alternate

ProfessorPeterCollins

Faculty of Medicine, National Heart & Lung Institute

Professor of Clinical Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8112peter.collins

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ardissino:2019:eurheartj/ehz748.0049,
author = {Ardissino, M and Moussa, OM and Tang, AR and Heaton, T and Ziprin, P and Khan, O and Darzi, A and Purkayastha, S and Collins, P},
doi = {eurheartj/ehz748.0049},
journal = {European Heart Journal},
title = {Effect of bariatric surgery on long-term cardiovascular outcomes in patients with obesity: a nation-wide nested cohort study},
url = {http://dx.doi.org/10.1093/eurheartj/ehz748.0049},
volume = {40},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title>               <jats:sec>                  <jats:title>Background</jats:title>                  <jats:p>Obesity is a cardinal risk factor for the development of atherosclerotic cardiovascular disease. Bariatric surgery is an effective method of achieving weight reduction and improving control of cardiovascular risk factors in patients with obesity. However, the effect of bariatric surgery on long-term cardiovascular outcomes has yet to be defined.</jats:p>               </jats:sec>               <jats:sec>                  <jats:title>Purpose</jats:title>                  <jats:p>The aim of this study is to evaluate the effect of bariatric surgery on long-term risk of major adverse cardiovascular events in a large population of patients with obesity.</jats:p>               </jats:sec>               <jats:sec>                  <jats:title>Methods</jats:title>                  <jats:p>A nested cohort study was carried out; including the 3,701 patients of the Clinical Practice Research Datalink database who had undergone bariatric surgery, and 3,701 age, gender and BMI matched controls. The primary endpoint was the composite of fatal or non-fatal myocardial infarction; and fatal or non-fatal acute ischaemic stroke. Secondary endpoints included all-cause mortality, new diagnosis of heart failure, fatal or non-fatal myocardial infarction, and fatal or non-fatal acute ischaemic stroke. Data was analysed using a Cox proportional hazards model to account for multiple covariates.</jats:p>               </jats:sec>               <jats:sec>                  <jats:title>Results</jats:title>                  <jats:p>Patients were followed up for a median of 11.2 years; 20.3% of the population were female, the median age was 36 years and median BMI was 40.4 kg/m2. Patients who had undergone bariatric surge
AU  - Ardissino,M
AU  - Moussa,OM
AU  - Tang,AR
AU  - Heaton,T
AU  - Ziprin,P
AU  - Khan,O
AU  - Darzi,A
AU  - Purkayastha,S
AU  - Collins,P
DO  - eurheartj/ehz748.0049
PY  - 2019///
SN  - 0195-668X
TI  - Effect of bariatric surgery on long-term cardiovascular outcomes in patients with obesity: a nation-wide nested cohort study
T2  - European Heart Journal
UR  - http://dx.doi.org/10.1093/eurheartj/ehz748.0049
VL  - 40
ER  -
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