Imperial College London
Alternate

ProfessorPeterCollins

Faculty of Medicine, National Heart & Lung Institute

Professor of Clinical Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8112peter.collins

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Moussa:2019,
author = {Moussa, O and Ardissino, M and Muttoni, S and Faraj, A and Tang, A and Ziprin, P and Darzi, A and Khan, O and Collins, P and Jaffer, U and Purkayastha, S},
pages = {1--2},
publisher = {Lippincott, Williams & Wilkins},
title = {Long-term effect of bariatric surgery on the incidence and outcomes of obesity-related peripheral vascular disease},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000529998006250&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Background: Patients with obesity are at high risk of suffering from both arterial and venous peripheral vascular disease. Bariatric surgery is an effective and increasingly popular strategy to achieve weight reduction and for patients with obesity. The long-term impact of bariatric surgery on obesity-related morbidity is a subject of increasing research interest.Hypothesis: The aim of this study is to ascertain the impact of bariatric surgery on the long-term occurrence of peripheral vascular disease in patients with obesity.Design: The study cohort consisted of 7,892 patients in theClinical Practice Research Datalink. This a prospectively collected nation-wide database containing primary and secondary care records of consenting patients. The intervention cohort were the 3,946 patients who had undergone bariatric surgery during follow-up; their controls were 3,946 age, gender and BMI-matched controls. The primary endpoint was considered to be the development of any peripheral vascualr disease: arterial or venous. Secondary endpoints included were peripheral arterial disease alone, peripheral venous disease alone, and amputation of a limb due to any cause. The median follow-up achieved in the study was 11.5 years.Results: A total of 1,244 patients suffered a primary endpoint during follow up; bariatric surgery was associated with a reduction in primary event rates (HR=0.651, 95%CI 0.558-0.758, p<0.001); this was driven by a reduction in both arterial and venous disease. The protective effect observed was strongest in women (p int<0.001), those with diabetes (p int<0.001) and those of WHO BMI Categories I and II (p int=0.003). Amputation rates were also non-significantly reduced in the bariatric surgery cohort HR=0.443, 95%CI 0.181-1.085, p=0.075).Conclusion: Bariatric surgery was associated with a reduction in the occurrence of both arterial and venous peripheral vascular disease in patients with obesity.
AU  - Moussa,O
AU  - Ardissino,M
AU  - Muttoni,S
AU  - Faraj,A
AU  - Tang,A
AU  - Ziprin,P
AU  - Darzi,A
AU  - Khan,O
AU  - Collins,P
AU  - Jaffer,U
AU  - Purkayastha,S
EP  - 2
PB  - Lippincott, Williams & Wilkins
PY  - 2019///
SN  - 0009-7322
SP  - 1
TI  - Long-term effect of bariatric surgery on the incidence and outcomes of obesity-related peripheral vascular disease
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000529998006250&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.ahajournals.org/doi/10.1161/circ.140.suppl_1.15511
UR  - http://hdl.handle.net/10044/1/88017
ER  -
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