Imperial College London
Alternate

ProfessorPeterCollins

Faculty of Medicine, National Heart & Lung Institute

Professor of Clinical Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8112peter.collins

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Webb:2021:10.1016/j.ijcard.2021.07.018,
author = {Webb, CM and Collins, P},
doi = {10.1016/j.ijcard.2021.07.018},
journal = {International Journal of Cardiology},
pages = {1--8},
title = {Medical management of anginal symptoms in women with stable angina pectoris: A systematic review of randomised controlled trials},
url = {http://dx.doi.org/10.1016/j.ijcard.2021.07.018},
volume = {341},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundMedical therapies are used to improve stable anginal symptoms and quality of life in clinical practice however the evidence for the use of antianginal medication in women is largely unknown. We conducted a systematic review to investigate the extent of the evidence-base for the medical management of anginal symptoms in women with stable angina.MethodsMEDLINE, EMBASE, Cochrane and ClinicalTrials.gov databases were searched to the end of December 2019. Retrieved papers were hand searched. Included were randomised controlled trials with at least one week of follow-up that included women with stable angina pectoris, with or without significant coronary atherosclerosis, randomised to conventional antianginal medication or/and a comparator, with a primary or secondary endpoint of angina frequency or glyceryl trinitrate (GTN) consumption.ResultsA total of 397 eligible publications were included in a qualitative analysis, with women comprising up to 20–30% of the study populations. No publication that included women and men reported all data separately for each sex. Twenty-six publications reported any female data separately from male data but only 18 reported angina data for women, 12 of which included fewer than 10 women.ConclusionsSubstantially fewer women than men were included in randomised trials of antianginal medications reporting effects on anginal symptoms, and reporting of data by sex was infrequent. As a result, there is little evidence on which to base treatment recommendations for anginal symptoms in women. Our results provide a platform for future studies to fill this void in the evidence.
AU  - Webb,CM
AU  - Collins,P
DO  - 10.1016/j.ijcard.2021.07.018
EP  - 8
PY  - 2021///
SN  - 0167-5273
SP  - 1
TI  - Medical management of anginal symptoms in women with stable angina pectoris: A systematic review of randomised controlled trials
T2  - International Journal of Cardiology
UR  - http://dx.doi.org/10.1016/j.ijcard.2021.07.018
UR  - https://www.sciencedirect.com/science/article/pii/S0167527321011633?via%3Dihub
UR  - http://hdl.handle.net/10044/1/90536
VL  - 341
ER  -
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