Imperial College London
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Emeritus ProfessorPeterSmith

Business School

Emeritus Professor of Health Policy
 
 
 
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Contact

 

peter.smith Website CV

 
 
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Location

 

c/o Lorraine SheehyBusiness School BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pires:2017,
author = {Pires, Barrenho EA and Miraldo, M and Smith, PC},
title = {Does global drug innovation correspond to burden of disease? The neglected diseases in developed and developing countries.},
url = {http://hdl.handle.net/10044/1/51581},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - While commonly argued that there is a mismatch between drug innovation and disease burden, there is little evidence on the magnitude and direction of such disparities. In this paper we measure inequality in innovation, by comparing R&D activity with population health and GDP data across 493 therapeutic indications to globally measure: (i) drug innovation, (ii) disease burden, and (iii) market size.We use concentration curves and indices to assess inequality at two levels: (i) broad disease groups; and (ii) disease subcategories for both 1990 and 2010.For some of top burden disease subcategories (i.e. cardiovascular and circulatory diseases, neoplasms, and musculoskeletal disorders) innovation is disproportionately concentrated in diseases with high burden and larger market size, whereas for others (i.e. mental and behavioural disorders, neonatal disorders, and neglected tropical diseases) innovation is disproportionately concentrated in low burden diseases.These inequalities persisted over time, suggesting inertia in pharmaceutical R&D in tackling the global health challenges.Our results highlight the priority disease areas for R&D investment in both developed and developing countries.
AU  - Pires,Barrenho EA
AU  - Miraldo,M
AU  - Smith,PC
PY  - 2017///
SN  - 1744-6783
TI  - Does global drug innovation correspond to burden of disease? The neglected diseases in developed and developing countries.
UR  - http://hdl.handle.net/10044/1/51581
ER  -
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