Peter Wright is a Post-Doctoral researcher within Professor Julia Gorelik's Functional Microscopy group at the National Heart and Lung Institute.
He began his career in the pharmaceutical industry before returning to academic research.
His PhD concerned in vivo and in vitro investigations of the effects of large doses of epinephrine (adrenaline) on cellular receptor signalling (β1AR/ β2AR) and heart function. This research aims to deepen our understanding of the pathological state underlying the syndrome of stress or tako-tsubo cardiomyopathy. This disorder is relatively rare but is increasingly reported in the medical literature and has a distinctive set of symptoms. The dysfunction underlying this disorder may contribute in minor ways to other forms of heart disease.
In the course of this work he became interested in the differences in the ultra-structural states of cardiomyocytes from different regions of the heart. He found that these differences have implications for physiology, pharmacology and in disease mechanisms.
His recent work has focused on the role of mechanical load in 'patterning' the structural state of cells from different regions of the heart. This work also assessed the load-dependent effects on the control of signalling molecules within cellular microdomains.
et al., 2018, Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains, Frontiers in Physiology, Vol:9, ISSN:1664-042X
et al., 2018, Heart failure leads to altered β2-adrenoceptor/cAMP dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain: Bastug et al. Phospholemman cAMP microdomain., Cardiovasc Res
et al., 2018, Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in beta(2)AR-cAMP Responsiveness in Murine Hearts, Cell Reports, Vol:23, ISSN:2211-1247, Pages:459-469
et al., 2017, T-tubule remodelling disturbs localized beta(2)-adrenergic signalling in rat ventricular myocytes during the progression of heart failure, Cardiovascular Research, Vol:113, ISSN:0008-6363, Pages:770-782
et al., 2017, FRET biosensor uncovers cAMP nano-domains at beta-adrenergic targets that dictate precise tuning of cardiac contractility, Nature Communications, Vol:8, ISSN:2041-1723