Imperial College London

DrPeterWright

Faculty of MedicineNational Heart & Lung Institute

Research Associate
 
 
 
//

Contact

 

peter.wright09

 
 
//

Location

 

L-Block 424ICTEM buildingHammersmith Campus

//

Summary

 

Summary

Peter Wright is a Post-Doctoral researcher jointly within the Functional Microscopy and Cellular Electrophysiology groups at the National Heart and Lung Institute.  He is supervised primarily by Professor Julia Gorelik and Professor Cesare Terraciano.

After completing his first degree at the University of Birmingham he began a career in the pharmaceutical industry. After a number of successful years he decided to return to academic research.

In 2009, he enrolled on the Imperial College 1+3-year PhD studentship (MRes Experimental Physiology and Pharmacology) funded by the MRC and administrated by CIMPP.  Peter was given a project in Dr Gorelik’s group as part of the assessment for the MRes component.

His PhD concerned in vivo and in vitro investigations of the effects of large doses of epinephrine (adrenaline) on cellular receptor signalling (β1AR/ β2AR) and heart function. This research aims to deepen our understanding of the pathological state underlying the syndrome of stress or tako-tsubo cardiomyopathy. This disorder is relatively rare but is increasingly reported in the medical literature and has a distinctive set of symptoms. The dysfunction underlying this disorder may contribute in minor ways to other forms of heart disease.  

Publications

Journals

Wright PT, Bhogal NK, Diakonov I, et al., 2018, Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in beta(2)AR-cAMP Responsiveness in Murine Hearts, Cell Reports, Vol:23, ISSN:2211-1247, Pages:459-469

Schobesberger S, Wright P, Tokar S, et al., 2017, T-tubule remodelling disturbs localized beta(2)-adrenergic signalling in rat ventricular myocytes during the progression of heart failure, Cardiovascular Research, Vol:113, ISSN:0008-6363, Pages:770-782

Surdo NC, Berrera M, Koschinski A, et al., 2017, FRET biosensor uncovers cAMP nano-domains at beta-adrenergic targets that dictate precise tuning of cardiac contractility, Nature Communications, Vol:8, ISSN:2041-1723

Miragoli M, Sanchez-Alonso JL, Bhargava A, et al., 2016, Microtubule-Dependent Mitochondria Alignment Regulates Calcium Release in Response to Nanomechanical Stimulus in Heart Myocytes, Cell Reports, Vol:14, ISSN:2211-1247, Pages:140-151

Conference

Derda AA, O'Gara P, Tranter MH, et al., 2015, Characterization of cardiac stress (Takotsubo syndrome)-related miRNAs ex vivo, Congress of the European-Society-of-Cardiology (ESC), OXFORD UNIV PRESS, Pages:1208-1209, ISSN:0195-668X

More Publications