Imperial College London
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DrPeterWright

Faculty of Medicine, National Heart & Lung Institute

Honorary Research Fellow
 
 
 
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peter.wright09

 
 
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Location

 

L-Block 424ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Swiatlowska:2020:10.1073/pnas.1917171117,
author = {Swiatlowska, P and Sanchez-Alonso, JL and Wright, PT and Novak, P and Gorelik, J},
doi = {10.1073/pnas.1917171117},
journal = {Proceedings of the National Academy of Sciences of USA},
pages = {2764--2766},
title = {Microtubules regulate cardiomyocyte transversal Young's modulus.},
url = {http://dx.doi.org/10.1073/pnas.1917171117},
volume = {117},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The field of cardiomyocyte mechanobiology is gaining significant attention, due to accumulating evidence concerning the significant role of cellular mechanical effects on the integrated function of the heart. To date, the protein titin has been demonstrated as a major contributor to the cardiomyocytes Young's modulus (YM). The microtubular network represents another potential regulator of cardiac mechanics. However, the contribution of microtubules (MTs) to the membrane YM is still understudied and has not been interrogated in the context of myocardial infarction (MI) or mechanical loading and unloading. Using nanoscale mechanoscanning ion conductance microscopy, we demonstrate that MTs contribute to cardiomyocyte transverse YM in healthy and pathological states with different mechanical loading. Specifically, we show that posttranslational modifications of MTs have differing effects on cardiomyocyte YM: Acetylation provides flexibility, whereas detyrosination imparts rigidity. Further studies demonstrate that there is no correlation between the total protein amount of acetylated and detyrosinated MT. Yet, in the polymerized-only populations, an increased level of acetylation results in a decline of detyrosinated MTs in an MI model.
AU  - Swiatlowska,P
AU  - Sanchez-Alonso,JL
AU  - Wright,PT
AU  - Novak,P
AU  - Gorelik,J
DO  - 10.1073/pnas.1917171117
EP  - 2766
PY  - 2020///
SN  - 0027-8424
SP  - 2764
TI  - Microtubules regulate cardiomyocyte transversal Young's modulus.
T2  - Proceedings of the National Academy of Sciences of USA
UR  - http://dx.doi.org/10.1073/pnas.1917171117
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31988123
UR  - https://www.pnas.org/content/117/6/2764
UR  - http://hdl.handle.net/10044/1/76738
VL  - 117
ER  -
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