Imperial College London
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DrPeterWright

Faculty of Medicine, National Heart & Lung Institute

Honorary Research Fellow
 
 
 
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Contact

 

peter.wright09

 
 
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Location

 

L-Block 424ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wright:2021:10.3390/cells10092456,
author = {Wright, PT and Gorelik, J and Harding, SE},
doi = {10.3390/cells10092456},
journal = {Cells},
title = {Electrophysiological remodeling: cardiac t-tubules and β-adrenoceptors},
url = {http://dx.doi.org/10.3390/cells10092456},
volume = {10},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Beta-adrenoceptors (βAR) are often viewed as archetypal G-protein coupled receptors. Over the past fifteen years, investigations in cardiovascular biology have provided remarkable insights into this receptor family. These studies have shifted pharmacological dogma, from one which centralized the receptor to a new focus on structural micro-domains such as caveolae and t-tubules. Important studies have examined, separately, the structural compartmentation of ion channels and βAR. Despite links being assumed, relatively few studies have specifically examined the direct link between structural remodeling and electrical remodeling with a focus on βAR. In this review, we will examine the nature of receptor and ion channel dysfunction on a substrate of cardiomyocyte microdomain remodeling, as well as the likely ramifications for cardiac electrophysiology. We will then discuss the advances in methodologies in this area with a specific focus on super-resolution microscopy, fluorescent imaging, and new approaches involving microdomain specific, polymer-based agonists. The advent of powerful computational modelling approaches has allowed the science to shift from purely empirical work, and may allow future investigations based on prediction. Issues such as the cross-reactivity of receptors and cellular heterogeneity will also be discussed. Finally, we will speculate as to the potential developments within this field over the next ten years.
AU  - Wright,PT
AU  - Gorelik,J
AU  - Harding,SE
DO  - 10.3390/cells10092456
PY  - 2021///
SN  - 2073-4409
TI  - Electrophysiological remodeling: cardiac t-tubules and β-adrenoceptors
T2  - Cells
UR  - http://dx.doi.org/10.3390/cells10092456
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000699146500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/92289
VL  - 10
ER  -
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