Imperial College London
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DrPeterWright

Faculty of Medicine, National Heart & Lung Institute

Honorary Research Fellow
 
 
 
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Contact

 

peter.wright09

 
 
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Location

 

L-Block 424ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wright:2014:10.1253/circj.CJ-14-0623,
author = {Wright, PT and Tranter, MH and Morley-Smith, AC and Lyon, AR},
doi = {10.1253/circj.CJ-14-0623},
journal = {Circulation Journal},
pages = {1550--1558},
title = {Pathophysiology of Takotsubo Syndrome - Temporal Phases of Cardiovascular Responses to Extreme Stress},
url = {http://dx.doi.org/10.1253/circj.CJ-14-0623},
volume = {78},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Takotsubo syndrome (TTS), also known as takotsubo cardiomyopathy, is an acute heart failure syndrome thattypically occurs after a period of great emotional stress. The archetypal patient is a postmenopausal woman whopresents with chest pain, ST-segment elevation and acute hypokinesia of the apical and middle segment of the leftventricle that extends beyond the territory of a single coronary artery, coupled with hyperkinesia of the basal myocardium.Recent preclinical and clinical studies have shown the importance of high catecholamine levels in precipitatingTTS. We propose that this is caused by activation of β-adrenoceptors and the subsequent activation of anegatively-inotropic pathway, perhaps to protect the heart from catecholamine overload. We explore the pathophysiologyof TTS according to its “phases”, both preclinically and clinically. This will show that the condition is notone of static apical hypokinesia that simply improves, but rather a dynamic condition that changes as the diseaseprogresses. We hope that further exploration of TTS using its “phases” will aid in its characterization, diagnosis andtreatment.
AU  - Wright,PT
AU  - Tranter,MH
AU  - Morley-Smith,AC
AU  - Lyon,AR
DO  - 10.1253/circj.CJ-14-0623
EP  - 1558
PY  - 2014///
SN  - 1347-4820
SP  - 1550
TI  - Pathophysiology of Takotsubo Syndrome - Temporal Phases of Cardiovascular Responses to Extreme Stress
T2  - Circulation Journal
UR  - http://dx.doi.org/10.1253/circj.CJ-14-0623
VL  - 78
ER  -
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