Imperial College London
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DrPeterWright

Faculty of Medicine, National Heart & Lung Institute

Honorary Research Fellow
 
 
 
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Contact

 

peter.wright09

 
 
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Location

 

L-Block 424ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wright:2015:10.3389/fphar.2015.00148,
author = {Wright, PT and Gorelik, J and Schobesberger, S},
doi = {10.3389/fphar.2015.00148},
journal = {Frontiers in Pharmacology},
title = {Studying GPCR/cAMP pharmacologyfrom the perspective of cellularstructure},
url = {http://dx.doi.org/10.3389/fphar.2015.00148},
volume = {6},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Signal transduction via G-protein coupled receptors (GPCRs) relies upon the productionof cAMP and other signaling cascades. A given receptor and agonist pair, producemultiple effects upon cellular physiology which can be opposite in different cell types.The production of variable cellular effects via the signaling of the same GPCR in differentcell types is a result of signal organization in space and time (compartmentation).This organization is usually based upon the physical and chemical properties of themembranes in which the GPCRs reside and the repertoire of downstream effectors andco-factors that are available at that location. In this review we explore mechanisms ofGPCR signal compartmentation and broadly review the state-of-the-art methodologieswhich can be utilized to study them. We provide a clear rationale for a “localized”approach to the study of the pharmacology and physiology of GPCRs and particularlythe secondary messenger cAMP.
AU  - Wright,PT
AU  - Gorelik,J
AU  - Schobesberger,S
DO  - 10.3389/fphar.2015.00148
PY  - 2015///
SN  - 1663-9812
TI  - Studying GPCR/cAMP pharmacologyfrom the perspective of cellularstructure
T2  - Frontiers in Pharmacology
UR  - http://dx.doi.org/10.3389/fphar.2015.00148
UR  - http://hdl.handle.net/10044/1/27830
VL  - 6
ER  -
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