Imperial College London
Alternate

ProfessorPetraHajkova

Faculty of Medicine, Institute of Clinical Sciences

Professor of Developmental Epigenetics
 
 
 
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Contact

 

+44 (0)20 7594 6754petra.hajkova Website

 
 
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Location

 

5.11CLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Carrillo-Jimenez:2019:10.1101/592055,
author = {Carrillo-Jimenez, A and Deniz, Ö and Niklison-Chirou, MV and Ruiz, R and Bezerra-Salomão, K and Stratoulias, V and Amouroux, R and Yip, PK and Vilalta, A and Cheray, M and Scott-Egerton, AM and Rivas, E and Tayara, K and García-Domínguez, I and Garcia-Revilla, J and Fernandez-Martin, JC and Espinosa-Oliva, AM and Shen, X and StGeorge-Hyslop, P and Brown, GC and Hajkova, P and Joseph, B and Venero, JL and Branco, MR and Burguillos, MA},
doi = {10.1101/592055},
title = {TET2 regulates the neuroinflammatory response in microglia},
url = {http://dx.doi.org/10.1101/592055},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Summary</jats:title><jats:p>Epigenetic mechanisms regulate distinct aspects of the inflammatory response in various immune cell types. Despite the central role for microglia, the resident macrophages of the brain, in neuroinflammation and neurodegeneration little is known about their epigenetic regulation of the inflammatory response. Here, we show that Ten-eleven translocation 2 (TET2) methylcytosine dioxygenase expression is increased in microglia upon stimulation with various inflammogens through a NF-κB-dependent pathway. We found that TET2 regulates early gene transcriptional changes that lead to early metabolic alterations, as well as a later inflammatory response independently of its 5mC oxidation activity at the affected genes. We further show that TET2 regulates the proinflammatory response in microglia induced by intraperitoneal injection of LPS<jats:italic>in vivo</jats:italic>. We observed that microglia associated to amyloid β plaques, recently defined as disease-associated microglia, expressed TET2 in brain tissue from individuals with Alzheimer’s disease (AD) and in 5×FAD mice. Collectively, our findings show that TET2 plays an important role in the microglial inflammatory response, and suggest TET2 as a potential target to combat neurodegenerative brain disorders.</jats:p>
AU  - Carrillo-Jimenez,A
AU  - Deniz,Ö
AU  - Niklison-Chirou,MV
AU  - Ruiz,R
AU  - Bezerra-Salomão,K
AU  - Stratoulias,V
AU  - Amouroux,R
AU  - Yip,PK
AU  - Vilalta,A
AU  - Cheray,M
AU  - Scott-Egerton,AM
AU  - Rivas,E
AU  - Tayara,K
AU  - García-Domínguez,I
AU  - Garcia-Revilla,J
AU  - Fernandez-Martin,JC
AU  - Espinosa-Oliva,AM
AU  - Shen,X
AU  - StGeorge-Hyslop,P
AU  - Brown,GC
AU  - Hajkova,P
AU  - Joseph,B
AU  - Venero,JL
AU  - Branco,MR
AU  - Burguillos,MA
DO  - 10.1101/592055
PY  - 2019///
TI  - TET2 regulates the neuroinflammatory response in microglia
UR  - http://dx.doi.org/10.1101/592055
ER  -
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