Imperial College London
Alternate

ProfessorPetraHajkova

Faculty of Medicine, Institute of Clinical Sciences

Professor of Developmental Epigenetics
 
 
 
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Contact

 

+44 (0)20 7594 6754petra.hajkova Website

 
 
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Location

 

5.11CLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Carrillo-Jimenez:2019:10.1016/j.celrep.2019.09.013,
author = {Carrillo-Jimenez, A and Deniz, Ö and Niklison-Chirou, MV and Ruiz, R and Bezerra-Salomão, K and Stratoulias, V and Amouroux, R and Yip, PK and Vilalta, A and Cheray, M and Scott-Egerton, AM and Rivas, E and Tayara, K and García-Domínguez, I and Garcia-Revilla, J and Fernandez-Martin, JC and Espinosa-Oliva, AM and Shen, X and St, George-Hyslop P and Brown, GC and Hajkova, P and Joseph, B and Venero, JL and Branco, MR and Burguillos, MA},
doi = {10.1016/j.celrep.2019.09.013},
journal = {Cell Reports},
pages = {697--713.e8},
title = {TET2 regulates the neuroinflammatory response in microglia},
url = {http://dx.doi.org/10.1016/j.celrep.2019.09.013},
volume = {29},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic regulation of the inflammatory response. Here, we show that Ten-eleven translocation 2 (TET2) methylcytosine dioxygenase expression is increased in microglia upon stimulation with various inflammogens through a NF-κB-dependent pathway. We found that TET2 regulates early gene transcriptional changes, leading to early metabolic alterations, as well as a later inflammatory response independently of its enzymatic activity. We further show that TET2 regulates the proinflammatory response in microglia of mice intraperitoneally injected with LPS. We observed that microglia associated with amyloid β plaques expressed TET2 in brain tissue from individuals with Alzheimer's disease (AD) and in 5xFAD mice. Collectively, our findings show that TET2 plays an important role in the microglial inflammatory response and suggest TET2 as a potential target to combat neurodegenerative brain disorders.
AU  - Carrillo-Jimenez,A
AU  - Deniz,Ö
AU  - Niklison-Chirou,MV
AU  - Ruiz,R
AU  - Bezerra-Salomão,K
AU  - Stratoulias,V
AU  - Amouroux,R
AU  - Yip,PK
AU  - Vilalta,A
AU  - Cheray,M
AU  - Scott-Egerton,AM
AU  - Rivas,E
AU  - Tayara,K
AU  - García-Domínguez,I
AU  - Garcia-Revilla,J
AU  - Fernandez-Martin,JC
AU  - Espinosa-Oliva,AM
AU  - Shen,X
AU  - St,George-Hyslop P
AU  - Brown,GC
AU  - Hajkova,P
AU  - Joseph,B
AU  - Venero,JL
AU  - Branco,MR
AU  - Burguillos,MA
DO  - 10.1016/j.celrep.2019.09.013
EP  - 713
PY  - 2019///
SN  - 2211-1247
SP  - 697
TI  - TET2 regulates the neuroinflammatory response in microglia
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2019.09.013
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31618637
UR  - http://hdl.handle.net/10044/1/74124
VL  - 29
ER  -
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