Imperial College London
Alternate

ProfessorPetraHajkova

Faculty of Medicine, Institute of Clinical Sciences

Professor of Developmental Epigenetics
 
 
 
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Contact

 

+44 (0)20 7594 6754petra.hajkova Website

 
 
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Location

 

5.11CLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Catania:2020:10.1016/j.cell.2019.12.012,
author = {Catania, S and Dumesic, PA and Pimentel, H and Nasif, A and Stoddard, CI and Burke, JE and Diedrich, JK and Cook, S and Shea, T and Geinger, E and Lintner, R and Yates, JR and Hajkova, P and Narlikar, GJ and Cuomo, CA and Pritchard, JK and Madhani, HD},
doi = {10.1016/j.cell.2019.12.012},
journal = {Cell},
pages = {263--277.e20},
title = {Evolutionary persistence of DNA methylation for millions of years after ancient loss of a de Novo methyltransferase},
url = {http://dx.doi.org/10.1016/j.cell.2019.12.012},
volume = {180},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cytosine methylation of DNA is a widespread modification of DNA that plays numerous critical roles. In the yeast Cryptococcus neoformans, CG methylation occurs in transposon-rich repeats and requires the DNA methyltransferase Dnmt5. We show that Dnmt5 displays exquisite maintenance-type specificity in vitro and in vivo and utilizes similar in vivo cofactors as the metazoan maintenance methylase Dnmt1. Remarkably, phylogenetic and functional analysis revealed that the ancestral species lost the gene for a de novo methylase, DnmtX, between 50–150 mya. We examined how methylation has persisted since the ancient loss of DnmtX. Experimental and comparative studies reveal efficient replication of methylation patterns in C. neoformans, rare stochastic methylation loss and gain events, and the action of natural selection. We propose that an epigenome has been propagated for >50 million years through a process analogous to Darwinian evolution of the genome.
AU  - Catania,S
AU  - Dumesic,PA
AU  - Pimentel,H
AU  - Nasif,A
AU  - Stoddard,CI
AU  - Burke,JE
AU  - Diedrich,JK
AU  - Cook,S
AU  - Shea,T
AU  - Geinger,E
AU  - Lintner,R
AU  - Yates,JR
AU  - Hajkova,P
AU  - Narlikar,GJ
AU  - Cuomo,CA
AU  - Pritchard,JK
AU  - Madhani,HD
DO  - 10.1016/j.cell.2019.12.012
EP  - 277
PY  - 2020///
SN  - 0092-8674
SP  - 263
TI  - Evolutionary persistence of DNA methylation for millions of years after ancient loss of a de Novo methyltransferase
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2019.12.012
UR  - https://www.sciencedirect.com/science/article/pii/S0092867419313741?via%3Dihub
VL  - 180
ER  -
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