Imperial College London
Alternate

DrPhilipMiller

Faculty of Natural Sciences, Department of Chemistry

Reader in Applied Synthesis
 
 
 
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Contact

 

philip.miller Website

 
 
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Location

 

501kMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rasekh:2017:10.1021/acs.molpharmaceut.7b00109,
author = {Rasekh, M and Ahmad, Z and Cross, R and Hernandez-Gil, J and Wilton-Ely, JDET and Miller, PW},
doi = {10.1021/acs.molpharmaceut.7b00109},
journal = {MOLECULAR PHARMACEUTICS},
pages = {2010--2023},
title = {Facile Preparation of Drug-Loaded Tristearin Encapsulated Superparamagnetic Iron Oxide Nanoparticles Using Coaxial Electrospray Processing},
url = {http://dx.doi.org/10.1021/acs.molpharmaceut.7b00109},
volume = {14},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Naturally occurring polymers are promising biocompatible materials that have many applications for emerging therapies, drug delivery systems, and diagnostic agents. The handling and processing of such materials still constitutes a major challenge, which can limit the full exploitation of their properties. This study explores an ambient environment processing technique: coaxial electrospray (CO-ES) to encapsulate genistein (an isoflavonoid and model drug), superparamagnetic iron oxide nanoparticles (SPIONs, 10–15 nm), and a fluorophore (BODIPY) into a layered (triglyceride tristearin shell) particulate system, with a view to constructing a theranostic agent. Mode mapping of CO-ES led to an optimized atomization engineering window for stable jetting, leading to encapsulation of SPIONs within particles of diameter 0.65–1.2 μm and drug encapsulation efficiencies of around 92%. Electron microscopy was used to image the encapsulated SPIONs and confirm core–shell triglyceride encapsulation in addition to further physicochemical characterization (AFM, FTIR, DSC, and TGA). Cell viability assays (MTT, HeLa cells) were used to determine optimal SPION loaded particles (∼1 mg/mL), while in vitro release profile experiments (PBS, pH = 7.4) demonstrate a triphasic release profile. Further cell studies confirmed cell uptake and internalization at selected time points (t = 1, 2, and 4 h). The results suggest potential for using the CO-ES technique as an efficient way to encapsulate SPIONs together with sensitive drugs for the development of multimodal particles that have potential application for combined imaging and therapy.
AU  - Rasekh,M
AU  - Ahmad,Z
AU  - Cross,R
AU  - Hernandez-Gil,J
AU  - Wilton-Ely,JDET
AU  - Miller,PW
DO  - 10.1021/acs.molpharmaceut.7b00109
EP  - 2023
PY  - 2017///
SN  - 1543-8384
SP  - 2010
TI  - Facile Preparation of Drug-Loaded Tristearin Encapsulated Superparamagnetic Iron Oxide Nanoparticles Using Coaxial Electrospray Processing
T2  - MOLECULAR PHARMACEUTICS
UR  - http://dx.doi.org/10.1021/acs.molpharmaceut.7b00109
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000402950500017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/49396
VL  - 14
ER  -
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