Philippa is a visiting researcher at Imperial College. She completed a PhD in leukaemia genomics in 2018, and finished her first post doc, funded by a Kay Kendall Leukaemia Fund project grant, in 2021.
Philippa's interest is in chromatin modification and non-coding regulatory elements in myeloid leukaemia. She uses various NGS-based methods, such as ChIP-seq, ATAC-seq and chromosome conformation capture-seq (4C). She was given an Early Career Development grant by Leukaemia UK in 2019.
Philippa is a Consultant Clinical Scientist in Genomics and leads the specialist paediatric integrated haematology & malignancy diagnostic service (SIHMDS) at Great Ormond Street Hospital, part of the North Thames Genomic Laboratory Hub. She was previously the lead of Developmental Disorders at Guy's & St Thomas' NHS Foundation Trust and Head of Education and Development for Healthcare Science at the Royal Free London NHS Foundation Trust.
Karadimitris A, 2021, Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma, Nature Communications, Vol:12, ISSN:2041-1723, Pages:1-16
et al., 2021, Optimized protocol for a quantitative SARS-CoV-2 duplex RT-qPCR assay with internal human sample sufficiency control., Journal of Virological Methods, Vol:294, ISSN:0166-0934, Pages:1-7
et al., 2020, Three distinct hematological malignancies from a single germ cell tumor: a case report., Journal of Medical Case Reports, Vol:14, ISSN:1752-1947
et al., 2020, Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions, Blood Cancer Discovery, Vol:1, ISSN:2643-3230, Pages:48-67
et al., 2019, Complete remission with incomplete count recovery (CRi) prior to allogeneic HCT for acute myeloid leukaemia is associated with a high non-relapse mortality., Leukemia, Vol:34, ISSN:1476-5551, Pages:667-670
et al., 2017, Lineage-specific genes are prominent DNA damage hotspots during leukemic transformation of B-cell precursors, Cell Reports, Vol:18, ISSN:2211-1247, Pages:1687-1698