Imperial College London
Dr Philippa C. May

Dr Philippa C. May

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Researcher
 
 
 
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Contact

 

philippa.may

 
 
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Location

 

4N5Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Karadimitris:2021:10.1038/s41467-021-25704-2,
author = {Karadimitris, A},
doi = {10.1038/s41467-021-25704-2},
journal = {Nature Communications},
pages = {1--16},
title = {Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma},
url = {http://dx.doi.org/10.1038/s41467-021-25704-2},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Multiple myeloma is a genetically heterogeneous cancer of the bone marrow plasma cells (PC). Distinct myeloma transcriptome profiles are primarily driven by myelomainitiating events (MIE) and converge into a mutually exclusive overexpression of the CCND1 and CCND2 oncogenes. Here, with reference to their normal counterparts, we find that myeloma PC enhanced chromatin accessibility combined with paired transcriptome profiling can classify MIE-defined genetic subgroups. Across and within different MM genetic subgroups, we ascribe regulation of genes and pathways critical for myeloma biology to unique or shared, developmentally activated or de novo formed candidate enhancers. Such enhancers co-opt recruitment of existing transcription factors, which although not transcriptionally deregulated per se, organise aberrant gene regulatory networks that help identify myeloma cell dependencies with prognostic impact. Finally, we identify and validate the critical super-enhancer that regulates ectopic expression of CCND2 in a subset of patients with MM and in chronic lymphocytic leukemia.
AU  - Karadimitris,A
DO  - 10.1038/s41467-021-25704-2
EP  - 16
PY  - 2021///
SN  - 2041-1723
SP  - 1
TI  - Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-25704-2
UR  - https://www.nature.com/articles/s41467-021-25704-2
UR  - http://hdl.handle.net/10044/1/91279
VL  - 12
ER  -
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