Imperial College London
Dr Philippa C. May

Dr Philippa C. May

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Researcher
 
 
 
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Contact

 

philippa.may

 
 
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Location

 

4N5Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Boulianne:2017:10.1016/j.celrep.2017.01.057,
author = {Boulianne, B and Robinson, ME and May, PC and Castellano, L and Blighe, K and Thomas, J and Reid, A and Muschen, M and Apperley, JF and Stebbing, J and Feldhahn, N},
doi = {10.1016/j.celrep.2017.01.057},
journal = {Cell Reports},
pages = {1687--1698},
title = {Lineage-specific genes are prominent DNA damage hotspots during leukemic transformation of B-cell precursors},
url = {http://dx.doi.org/10.1016/j.celrep.2017.01.057},
volume = {18},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In human leukemia, lineage-specific genes represent predominant targets of deletion, with lymphoid-specific genes frequently affected in lymphoid leukemia and myeloid-specific genes in myeloid leukemia. To investigate the basis of lineage-specific alterations, we analyzed global DNA damage in primary B-cell precursors expressing leukemia-inducing oncogenes by ChIP-Seq. We identified >1000 sensitive regions, of which B-lineage-specific genes constitute the most prominent targets. Identified hotspots at B-lineage genes relate to DNA-DSBs, affect genes that harbor genomic lesions in human leukemia, and associate with ectopic deletionin successfully transformed cells. We further show that mostidentified regions overlap with gene bodies of highly expressed genes, and that induction of a myeloidlineage phenotype in transformed B-cell precursors promotes de novoDNA damage atmyeloid loci. Hence, we demonstrate thatlineage-specific transcriptionpredisposeslineage-specificgenes in transformed B-cell precursorsto DNA damage, whichis likely to promote the frequent alteration oflineage-specific genes in human leukemia.
AU  - Boulianne,B
AU  - Robinson,ME
AU  - May,PC
AU  - Castellano,L
AU  - Blighe,K
AU  - Thomas,J
AU  - Reid,A
AU  - Muschen,M
AU  - Apperley,JF
AU  - Stebbing,J
AU  - Feldhahn,N
DO  - 10.1016/j.celrep.2017.01.057
EP  - 1698
PY  - 2017///
SN  - 2211-1247
SP  - 1687
TI  - Lineage-specific genes are prominent DNA damage hotspots during leukemic transformation of B-cell precursors
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2017.01.057
UR  - http://hdl.handle.net/10044/1/44202
VL  - 18
ER  -
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