DrPierangelaSabbattini

Faculty of Medicine, Department of Immunology and Inflammation

Research Associate

Contact

Location

4S9Commonwealth BuildingHammersmith Campus

Summary

Dr Pierangela Sabbattini is an epigenetics and immune cell biologist. She carried out her undergraduate degree in Biology and her PhD in Molecular Biology at the University of Milan, Italy. She was awarded a University of Milan International Fellowship to carry out her postdoctoral training in London where she soon joined Prof Niall Dillon’s lab at the MRC CSC Institute (now LMS), working on the epigenetic regulation of the surrogate light chain locus in B lymphocytes and on epigenetic chromatin changes associated with cell differentiation. She obtained an MRC Senior Research Scientist position (2002) and an Imperial College Honorary Lectureship (2007) in Prof Dillon’s lab at the MRC LMS, where she worked till 2021 on gene regulation during B cell activation, the role of the RUNX factors in BCR signalling and aspects of plasma cell gene regulation and plasma cell death. Since 2021, she joined as senior PDRA Prof Tassos Karadimitris’ lab (The Hugh and Josseline Langmuir Centre for Myeloma Research - Department of Immunology and Inflammation - Imperial College London) to study the role of epigenetic factors as dependencies in multiple myeloma. In 2023 she was awarded a Blood Fund fellowship and her research work is funded by a Blood Cancer UK grant.

email: pierangela.sabbattini@imperial.ac.uk

Publications

Journals

Katsarou A, Trasanidis N, Ponnusamy K, et al.Katsarou A, Trasanidis N, Ponnusamy K, Kostopoulos IV, Alvarez-Benayas J, Papaleonidopoulou F, Keren K, Sabbattini PM, Feldhahn N, Papaioannou M, Hatjiharissi E, Sudbery IM, Chaidos A, Caputo VS, Karadimitris A close, 2023, MAF functions as a pioneer transcription factor that initiates and sustains myelomagenesis., Blood Adv

Trasanidis N, Katsarou A, Ponnusamy K, et al.Trasanidis N, Katsarou A, Ponnusamy K, Shen Y-A, Kostopoulos I, Bergonia B, Keren K, Reema P, Xiao X, Szydlo RM, Sabbattini PMR, Roberts IAG, Auner HW, Naresh KN, Chaidos A, Wang T-L, Magnani L, Caputo VS, Karadimitris A close, 2022, Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma, Blood, Vol:139, ISSN:0006-4971, Pages:1939-1953

Thomsen I, Kunowska N, de Souza R, et al.Thomsen I, Kunowska N, de Souza R, Moody A-M, Crawford G, Wang Y-F, Khadayate S, Whilding C, Strid J, Karimi MM, Barr AR, Dillon N, Sabbattini P close, 2021, RUNX1 regulates a transcription program that affects the dynamics of cell cycle entry of naive resting B cells, Journal of Immunology, Vol:207, ISSN:0022-1767, Pages:2976-2991

Sarkar M, Martufi M, Roman-Trufero M, et al.Sarkar M, Martufi M, Roman-Trufero M, Wang Y-F, Whilding C, Dormann D, Sabbattini P, Dillon N close, 2021, CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells, Molecular Biology of the Cell, Vol:32, ISSN:1044-2030

Bond J, Domaschenz R, Roman-Trufero M, et al.Bond J, Domaschenz R, Roman-Trufero M, Sabbattini P, Ferreiros-Vidal I, Gerrard G, Asnafi V, Macintyre E, Merkenschlager M, Dillon N close, 2016, Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia, Oncotarget, Vol:7, ISSN:1949-2553, Pages:65923-65936

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