Imperial College London
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DrPierangelaSabbattini

Faculty of Medicine, Department of Immunology and Inflammation

Research Associate
 
 
 
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Contact

 

pierangela.sabbattini

 
 
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Location

 

4S9Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Thompson:2007:10.1016/j.immuni.2007.02.010,
author = {Thompson, EC and Cobb, BS and Sabbattini, P and Meixlsperger, S and Parelho, V and Liberg, D and Taylor, B and Dillon, N and Georgopoulos, K and Jumaa, H and Smale, ST and Fisher, AG and Merkenschlager, M},
doi = {10.1016/j.immuni.2007.02.010},
journal = {Immunity},
pages = {335--344},
title = {Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.},
url = {http://dx.doi.org/10.1016/j.immuni.2007.02.010},
volume = {26},
year = {2007}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ikaros DNA-binding proteins are critical for the development of lymphocytes and other hematopoietic lineages, but it remains unclear how they cooperate with other regulators of signaling and transcription to achieve ordered gene expression during development. Here, we show that Ikaros proteins regulate the pre-BCR component lambda5 in a stage-specific manner. In pre-BI cells, Ikaros modulated lambda5 expression in competition with the transcriptional activator EBF. This required Ikaros binding to the Igll1 (lambda5) promoter and was abolished either by mutation of the Ikaros DNA-binding domain or by deletion of a single Ikaros site from the Igll1 promoter. At the transition from the pre-BI to pre-BII stage, the expression of the Ikaros family member Aiolos was upregulated and required for the efficient silencing of Igll1. Aiolos expression was controlled by pre-BCR signals via the adaptor protein SLP-65. Thus, pre-BCR signaling regulates Aiolos and the silencing of Igll1 via a developmental-stage-specific feedback loop.
AU  - Thompson,EC
AU  - Cobb,BS
AU  - Sabbattini,P
AU  - Meixlsperger,S
AU  - Parelho,V
AU  - Liberg,D
AU  - Taylor,B
AU  - Dillon,N
AU  - Georgopoulos,K
AU  - Jumaa,H
AU  - Smale,ST
AU  - Fisher,AG
AU  - Merkenschlager,M
DO  - 10.1016/j.immuni.2007.02.010
EP  - 344
PY  - 2007///
SN  - 1074-7613
SP  - 335
TI  - Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.
T2  - Immunity
UR  - http://dx.doi.org/10.1016/j.immuni.2007.02.010
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17363301&query_hl=1
VL  - 26
ER  -
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