My research focuses on establishing non-invasive methods for disease detection and monitoring. Within this theme of research, I have developed specific interest in the application of exhaled breath analysis and radiological assessment of human body composition for the purpose of cancer early detection, therapeutic monitoring and prognostication.
This work seeks to define the underpinning tumour biology and complex role of the onco-microbial axis in VOC production in intestinal cancer. Central to this has been the development of reliable in vivo and in vitro models in which to explore the origins of VOCs. Once known, we propose to exploit these mechanisms to augment VOC production and hence improve the diagnostic performance of the intended breath test for cancer early detection.
My other research focuses on the analysis of CT parameters of body composition in patients treated with oesophageal cancer. Initial studies have sought to define reliable high throughput methods for non-invasive assessment in clinical practice. Subsequent studies will determine their role within future clinical practice.
et al., 2021, Challenges to quality assurance of surgical interventions in clinical oncology trials: A systematic review, Ejso, Vol:47, ISSN:0748-7983, Pages:748-756
et al., 2020, Urinary volatile organic compound analysis for the diagnosis of cancer: a systematic literature review and quality assessment, Metabolites, Vol:11, ISSN:2218-1989, Pages:17-17
et al., 2020, Severe Dumping Symptoms Are Uncommon Following Transthoracic Esophagectomy But Significantly Decrease Health-Related Quality of Life in Long-Term, Disease-Free Survivors, Journal of Gastrointestinal Surgery, Vol:25, ISSN:1091-255X, Pages:1941-1947
et al., 2020, The management of acute lower gastrointestinal bleeding using a Sengstaken-Blakemore tube, International Journal of Surgery Case Reports, Vol:75, ISSN:2210-2612, Pages:394-397
et al., 2020, Emergence of genomic diversity and recurrent mutations in SARS-CoV-2, Infection Genetics and Evolution, Vol:83, ISSN:1567-1348