Summary
My research focuses on establishing non-invasive methods for disease detection and monitoring. Within this theme of research, I have developed specific interest in the application of exhaled breath analysis and radiological assessment of human body composition for the purpose of cancer early detection, therapeutic monitoring and prognostication.
This work seeks to define the underpinning tumour biology and complex role of the onco-microbial axis in VOC production in intestinal cancer. Central to this has been the development of reliable in vivo and in vitro models in which to explore the origins of VOCs. Once known, we propose to exploit these mechanisms to augment VOC production and hence improve the diagnostic performance of the intended breath test for cancer early detection.
My other research focuses on the analysis of CT parameters of body composition in patients treated with oesophageal cancer. Initial studies have sought to define reliable high throughput methods for non-invasive assessment in clinical practice. Subsequent studies will determine their role within future clinical practice.
Publications
Journals
Halliday LJ, Boshier PR, Doganay E, et al., 2023, The effects of prehabilitation on body composition in patients undergoing multimodal therapy for esophageal cancer, Diseases of the Esophagus, Vol:36, ISSN:1120-8694
Wen Q, Myridakis A, Boshier PR, et al., 2023, A complete pipeline for untargeted urinary volatolomic profiling with sorptive extraction and dual polar and nonpolar column methodologies coupled with gas chromatography time-of-flight mass spectrometry., Analytical Chemistry, Vol:95, ISSN:0003-2700, Pages:758-765
Baggaley AE, Lafaurie GBRC, Tate SJ, et al., 2023, Pressurized intraperitoneal aerosol chemotherapy (PIPAC): updated systematic review using the IDEAL framework, British Journal of Surgery, Vol:110, ISSN:0007-1323, Pages:10-18
Mitra A, Choi S, Boshier P, et al., 2022, The human skin volatolome: a systematic review of untargeted mass spectrometry analysis, Metabolites, Vol:12, ISSN:2218-1989, Pages:1-18
Boshier PR, Klevebro F, Schmidt A, et al., 2022, Impact of Early Jejunostomy Tube Feeding on Clinical Outcome and Parameters of Body Composition in Esophageal Cancer Patients Receiving Multimodal Therapy, Annals of Surgical Oncology, Vol:29, ISSN:1068-9265, Pages:5689-5697