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@article{Hagens:2020:10.1002/jcsm.12540,
author = {Hagens, E and Feenstra, M and Egmond, M and Laarhoven, H and Hulshof, M and Boshier, P and Low, D and van, Berge Henegouwen M and Gisbertz, S},
doi = {10.1002/jcsm.12540},
journal = {Journal of Cachexia, Sarcopenia and Muscle},
pages = {756--767},
title = {Influence of body composition and muscle strength on outcomes after multimodal esophageal cancer treatment},
url = {http://dx.doi.org/10.1002/jcsm.12540},
volume = {11},
year = {2020}
}

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TY - JOUR
AB - Background: Influence of sarcopenia in combination with other body composition parameters and muscle strength on outcomes after esophageal surgery for esophageal cancer remains unclear. The objectives were to: 1. Describe the incidence of sarcopenia in relation to adipose tissue quantity and distribution and muscle strength. 2. To evaluate if neoadjuvant chemoradiation (nCRTx) influences body composition and muscle strength. 3. To evaluate the influence of body composition and muscle strength on postoperative morbidity and long-term survival.Methods: This retrospective study included patients with esophageal cancer who received nCRTx followed by surgery between January 2011 and 2016. Skeletal muscle, visceral and subcutaneous adipose tissue cross sectional areas were calculated based on CT scans and muscle strength was measured using hand grip tests, 30 seconds chair stand tests and maximal inspiratory and expiratory pressure tests prior to nCRTx and after nCRTx. Results: A total of 322 patients were included in this study. Sarcopenia was present in 55.6% of the patients prior to nCRTx and in 58.2% after nCRTx (p=0.082). Patients with sarcopenia had a significantly lower muscle strength and higher fat percentage. The muscle strength and incidence of sarcopenia increased whilst the mean BMI and fat percentage decreased during nCRTx. A BMI above 25 kg/m2 was associated with anastomotic leakage (p=0.032). Other body composition parameters were not associated with postoperative morbidity. A lower handgrip strength prior to nCRTx was associated with pulmonary and cardiac complications (p=0.023 and p=0.009 respectively). In multivariable analysis, a lower number of stands during the 30 seconds chair stand test prior to nCRTx (HR 0.93, 95%CI 0.87 – 0.99, p=0.017) and visceral adipose tissue of >128 cm2 after nCRTx (HR 1.81, 95%CI 1.30 – 2.53, p=0.001) were associated with worse overall survival. Conclusion:Sarcopenia occurs frequently in patients with esopha
AU - Hagens,E
AU - Feenstra,M
AU - Egmond,M
AU - Laarhoven,H
AU - Hulshof,M
AU - Boshier,P
AU - Low,D
AU - van,Berge Henegouwen M
AU - Gisbertz,S
DO - 10.1002/jcsm.12540
EP - 767
PY - 2020///
SN - 2190-6009
SP - 756
TI - Influence of body composition and muscle strength on outcomes after multimodal esophageal cancer treatment
T2 - Journal of Cachexia, Sarcopenia and Muscle
UR - http://dx.doi.org/10.1002/jcsm.12540
UR - http://hdl.handle.net/10044/1/76861
VL - 11
ER -

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