Imperial College London

DrPoppyLamberton

Faculty of MedicineSchool of Public Health

Honorary Senior Lecturer
 
 
 
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poppy.lamberton CV

 
 
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Praed StreetSt Mary's Campus

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Summary

 

Publications

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44 results found

Berger DJ, Crellen T, Lamberton PHL, Allan F, Tracey A, Noonan JD, Kabatereine NB, Tukahebwa EM, Adriko M, Holroyd N, Webster JP, Berriman M, Cotton JAet al., 2021, Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration, NATURE COMMUNICATIONS, Vol: 12, ISSN: 2041-1723

Journal article

Champion TS, Connelly S, Smith CJ, Lamberton PHLet al., 2020, Monitoring schistosomiasis and sanitation interventions-The potential of environmental DNA, WILEY INTERDISCIPLINARY REVIEWS-WATER, Vol: 8, ISSN: 2049-1948

Journal article

Trienekens SCM, Faust CL, Meginnis K, Pickering L, Ericsson O, Nankasi A, Moses A, Tukahebwa EM, Lamberton PHLet al., 2020, Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach, PLOS NEGLECTED TROPICAL DISEASES, Vol: 14, ISSN: 1935-2735

Journal article

Krauth SJ, Balen J, Gobert GN, Lamberton PHLet al., 2019, A call for systems epidemiology to tackle the complexity of Schistosomiasis, its control, and its elimination, Tropical Medicine and Infectious Disease, Vol: 4, ISSN: 2414-6366

Ever since the first known written report of schistosomiasis in the mid-19th century, researchers have aimed to increase knowledge of the parasites, their hosts, and the mechanisms contributing to infection and disease. This knowledge generation has been paramount for the development of improved intervention strategies. Yet, despite a broad knowledge base of direct risk factors for schistosomiasis, there remains a paucity of information related to more complex, interconnected, and often hidden drivers of transmission that hamper intervention successes and sustainability. Such complex, multidirectional, non-linear, and synergistic interdependencies are best understood by looking at the integrated system as a whole. A research approach able to address this complexity and find previously neglected causal mechanisms for transmission, which include a wide variety of influencing factors, is needed. Systems epidemiology, as a holistic research approach, can integrate knowledge from classical epidemiology, with that of biology, ecology, social sciences, and other disciplines, and link this with informal, tacit knowledge from experts and affected populations. It can help to uncover wider-reaching but difficult-to-identify processes that directly or indirectly influence exposure, infection, transmission, and disease development, as well as how these interrelate and impact one another. Drawing on systems epidemiology to address persisting disease hotspots, failed intervention programmes, and systematically neglected population groups in mass drug administration programmes and research studies, can help overcome barriers in the progress towards schistosomiasis elimination. Generating a comprehensive view of the schistosomiasis system as a whole should thus be a priority research agenda towards the strategic goal of morbidity control and transmission elimination.

Journal article

Adriko M, Faust CL, Carruthers LV, Moses A, Tukahebwa EM, Lamberton PHLet al., 2018, Low praziquantel treatment coverage for schistosoma mansoni in Mayuge District, Uganda, due to the absence of treatment opportunities, rather than systematic non-compliance, Tropical Medicine and Infectious Disease, Vol: 3, ISSN: 2414-6366

The World Health Organization (WHO) recommends praziquantel mass drug administration (MDA) to control schistosomiasis in endemic regions. We aimed to quantify recent and lifetime praziquantel coverage, and reasons for non-treatment, at an individual level to guide policy recommendations to help Uganda reach WHO goals. Cross-sectional household surveys (n = 681) encompassing 3208 individuals (adults and children) were conducted in 2017 in Bugoto A and B, Mayuge District, Uganda. Participants were asked if they had received praziquantel during the recent MDA (October 2016) and whether they had ever received praziquantel in their lifetime. A multivariate logistic regression analysis with socio-economic and individual characteristics as covariates was used to determine factors associated with praziquantel uptake. In the MDA eligible population (≥5 years of age), the most recent MDA coverage was 48.8%. Across individuals' lifetimes, 31.8% of eligible and 49.5% of the entire population reported having never taken praziquantel. Factors that improved individuals' odds of taking praziquantel included school enrolment, residence in Bugoto B and increasing years of village-residency. Not being offered (49.2%) and being away during treatment (21.4%) were the most frequent reasons for not taking the 2016 praziquantel MDA. Contrary to expectations, chronically-untreated individuals were rarely systematic non-compliers, but more commonly not offered treatment.

Journal article

Pitaksakulrat O, Webster BL, Webster JP, Laha T, Saijuntha W, Lamberton PHL, Kiatsopit N, Andrews RH, Petney TN, Sithithaworn Pet al., 2018, Phylogenetic relationships within the Opisthorchis viverrini species complex with specific analysis of O-viverrini sensu lato from Sakon Nakhon, Thailand by mitochondrial and nuclear DNA sequencing, INFECTION GENETICS AND EVOLUTION, Vol: 62, Pages: 86-94, ISSN: 1567-1348

Journal article

Jourdan PM, Lamberton PHL, Fenwick A, Addiss DGet al., 2018, Strongyloides stercoralis: the need for accurate information reply, LANCET, Vol: 391, Pages: 2323-2323, ISSN: 0140-6736

Journal article

Jourdan PM, Lamberton PHL, Fenwick A, Addiss DGet al., 2018, Soil-transmitted helminth infections, LANCET, Vol: 391, Pages: 252-265, ISSN: 0140-6736

Journal article

Prada JM, Touloupou P, Adriko M, Tukahebwa EM, Lamberton PHL, Hollingsworth TDet al., 2018, Understanding the relationship between egg- and antigen-based diagnostics of Schistosoma mansoni infection pre- and post-treatment in Uganda., Parasites & Vectors, Vol: 11, ISSN: 1756-3305

BACKGROUND: Schistosomiasis is a major socio-economic and public health problem in many sub-Saharan African countries. After large mass drug administration (MDA) campaigns, prevalence of infection rapidly returns to pre-treatment levels. The traditional egg-based diagnostic for schistosome infections, Kato-Katz, is being substituted in many settings by circulating antigen recognition-based diagnostics, usually the point-of-care circulating cathodic antigen test (CCA). The relationship between these diagnostics is poorly understood, particularly after treatment in both drug-efficacy studies and routine monitoring. RESULTS: We created a model of schistosome infections to better understand and quantify the relationship between these two egg- and adult worm antigen-based diagnostics. We focused particularly on the interpretation of "trace" results after CCA testing. Our analyses suggest that CCA is generally a better predictor of prevalence, particularly after treatment, and that trace CCA results are typically associated with truly infected individuals. CONCLUSIONS: Even though prevalence rises to pre-treatment levels only six months after MDAs, our model suggests that the average intensity of infection is much lower, and is probably in part due to a small burden of surviving juveniles from when the treatment occurred. This work helps to better understand CCA diagnostics and the interpretation of post-treatment prevalence estimations.

Journal article

Gower CM, Gehre F, Marques SR, Lamberton PHL, Lwambo NJ, Webster JPet al., 2017, Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme., Parasites & Vectors, Vol: 10, ISSN: 1756-3305

BACKGROUND: Schistosoma mansoni is a parasite of profound medical importance. Current control focusses on mass praziquantel (PZQ) treatment of populations in endemic areas, termed Preventative Chemotherapy (PC). Large-scale PC programmes exert prolonged selection pressures on parasites with the potential for, direct and/or indirect, emergence of drug resistance. Molecular methods can help monitor genetic changes of schistosome populations over time and in response to drug treatment, as well as estimate adult worm burdens through parentage analysis. Furthermore, methods such as in vitro drug sensitivity assays help phenotype in vivo parasite genotypic drug efficacy. METHODS: We conducted combined in vitro PZQ efficacy testing with population genetic analyses of S. mansoni collected from children from two schools in 2010, five years after the introduction of a National Control Programme. Children at one school had received four annual PZQ treatments and the other school had received two mass treatments in total. We compared genetic differentiation, indices of genetic diversity, and estimated adult worm burden from parasites collected in 2010 with samples collected in 2005 (before the control programme began) and in 2006 (six months after the first PZQ treatment). Using 2010 larval samples, we also compared the genetic similarity of those with high and low in vitro sensitivity to PZQ. RESULTS: We demonstrated that there were individual parasites with reduced PZQ susceptibility in the 2010 collections, as evidenced by our in vitro larval behavioural phenotypic assay. There was no evidence, however, that miracidia showing phenotypically reduced susceptibility clustered together genetically. Molecular analysis also demonstrated a significant reduction of adult worm load over time, despite little evidence of reduction in parasite infection intensity, as measured by egg output. Genetic diversity of infections did not reduce over time, despite changes in the genetic composit

Journal article

Viana M, Faust CL, Haydon DT, Webster JP, Lamberton PHLet al., 2017, The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni, Evolutionary Applications, Vol: 11, Pages: 488-500, ISSN: 1752-4571

Natural selection acts on all organisms, including parasites, to maximize reproductive fitness. Drug resistance traits are often associated with life-history costs in the absence of treatment. Schistosomiasis control programmes rely on mass drug administration to reduce human morbidity and mortality. Although hotspots of reduced drug efficacy have been reported, resistance is not widespread. Using Bayesian state-space models (SSMs) fitted to data from an in vivo laboratory system, we tested the hypothesis that the spread of resistant Schistosoma mansoni may be limited by life-history costs not present in susceptible counterparts. S. mansoni parasites from a praziquantel-susceptible (S), a praziquantel-resistant (R) or a mixed line of originally resistant and susceptible parasites (RS) were exposed to a range of praziquantel doses. Parasite numbers at each life stage were quantified in their molluscan intermediate and murine definitive hosts across four generations, and SSMs were used to estimate key life-history parameters for each experimental group over time. Model outputs illustrated that parasite adult survival and fecundity in the murine host decreased across all lines, including R, with increasing drug pressure. Trade-offs between adult survival and fecundity were observed in all untreated lines, and these remained strong in S with praziquantel pressure. In contrast, trade-offs between adult survival and fecundity were lost under praziquantel pressure in R. As expected, parasite life-history traits within the molluscan host were complex, but trade-offs were demonstrated between parasite establishment and cercarial output. The observed trade-offs between generations within hosts, which were modified by praziquantel treatment in the R line, could limit the spread of R parasites under praziquantel pressure. Whilst such complex life-history costs may be difficult to detect using standard empirical methods, we demonstrate that SSMs provide robust estimates of life-

Journal article

Harrington D, Lamberton PHL, McGregor A, 2017, Human liver flukes, LANCET GASTROENTEROLOGY & HEPATOLOGY, Vol: 2, Pages: 680-689, ISSN: 2468-1253

Journal article

Lamberton PHL, Faust CL, Webster JP, 2017, Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study, Infectious Diseases of Poverty, Vol: 6, ISSN: 2049-9957

BackgroundMass drug administration of praziquantel is the World Health Organization’s endorsed control strategy for schistosomiasis. A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence and intensity levels, although ‘hotspots’ remain. Repeated drug treatments place strong selective pressures on parasites, which may affect life-history traits that impact transmission dynamics. Understanding drug treatment responses and the evolution of such traits can help inform on how to minimise the risk of drug resistance developing, maximise sustainable control programme success, and improve diagnostic protocols.MethodsWe performed a four-generation Schistosoma mansoni praziquantel selection experiment in mice and snails. We used three S. mansoni lines: a praziquantel-resistant isolate (R), a praziquantel-susceptible isolate (S), and a co-infected line (RS), under three treatment regimens: untreated, 25 mg/kg praziquantel, or 50 mg/kg praziquantel. Life-history traits, including parasite adult-worm establishment, survival, reproduction (fecundity), and associated morbidity, were recorded in mice across all four generations. Predictor variables were tested in a series of generalized linear mixed effects models to determine which factors had a significant influence on parasite life-history traits in definitive hosts under different selection regimes.ResultsPraziquantel pressure significantly reduced adult-worm burdens across all generations and isolates, including within R-lines. However, previous drug treatment resulted in an increase in adult-worm establishment with increasing generation from P1 to F3. The highest worm numbers were in the co-infected RS line. Praziquantel treatment decreased adult-worm burden, but had a larger negative impact on the mean daily number of miracidia, a proxy for fecundity, across all three parasite isolates.ConclusionsOur predicted cost of resistance was not suppor

Journal article

Crainey JL, Hurst J, Lamberton PHL, Cheke RA, Griffin CE, Wilson MD, Mendes de Ara├║jo CP, Basanez MG, Post RJet al., 2017, The genomic architecture of novel simulium damnosum Wolbachia prophage sequence elements and implications for onchocerciasis epidemiology, Frontiers in Microbiology, Vol: 8, ISSN: 1664-302X

Research interest in Wolbachia is growing as new discoveries and technical advancements reveal the public health importance of both naturally occurring and artificial infections. Improved understanding of the Wolbachia bacteriophages (WOs) WOcauB2 and WOcauB3 (belonging to a sub-group of four WOs encoding serine recombinases group 1 (sr1WOs)), has enhanced the prospect of novel tools for the genetic manipulation of Wolbachia. The basic biology of sr1WOs, including host range and mode of genomic integration is, however, still poorly understood. Very few sr1WOs have been described, with two such elements putatively resulting from integrations at the same Wolbachia genome loci, about 2 kb downstream from the FtsZ cell-division gene. Here we characterise the DNA sequence flanking the FtsZ gene of wDam, a genetically distinct line of Wolbachia isolated from the West African onchocerciasis vector Simulium squamosum E. Using Roche 454 shot-gun and Sanger sequencing, we have resolved >32 kb of WO prophage sequence into 3 contigs representing three distinct prophage elements. Spanning ≥ 36 distinct WO open reading frame gene sequences, these prophage elements correspond roughly to three different WO modules: a serine recombinase and replication module (sr1RRM), a head and base-plate module and a tail module. The sr1RRM module contains replication genes and a Holliday junction recombinase and is unique to the sr1 group WOs. In the extreme terminal of the tail module there is an SpvB protein homologue—believed to have insecticidal properties and proposed to have a role in how Wolbachia parasitize their insect hosts. We propose that these wDam prophage modules all derive from a single WO genome, which we have named here sr1WOdamA1. The best-match database sequence for all of our sr1WOdamA1-predicted gene sequences was annotated as of Wolbachia or Wolbachia phage sourced from an arthropod. Clear evidence of exchange between sr1WOdamA1 and other Wolbachia WO phage seq

Journal article

Pitaksakulrat O, Kiatsopit N, Laoprom N, Webster BL, Webster JP, Lamberton PHL, Laha T, Andrews RH, Petney TN, Blair D, Carlton EJ, Spear RC, Sithithaworn Pet al., 2017, Preliminary genetic evidence of two different populations of Opisthorchis viverrini in Lao PDR, PARASITOLOGY RESEARCH, Vol: 116, Pages: 1247-1256, ISSN: 0932-0113

Journal article

Ding H, Gao Y-M, Deng Y, Lamberton PHL, Lu D-Bet al., 2017, A systematic review and meta-analysis of the seroprevalence of Toxoplasma gondii in cats in mainland China, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

Journal article

Gao Y-M, Ding H, Lamberton PHL, Lu D-Bet al., 2016, Prevalence of Toxoplasma gondii in pet dogs in mainland China: A meta-analysis, VETERINARY PARASITOLOGY, Vol: 229, Pages: 126-130, ISSN: 0304-4017

Journal article

Basanez M, Lamberton PHL, Cheke RA, Walker M, Winskill P, Crainey JL, Boakye DA, Osei-Atweneboana MY, Tirados I, Wilson MD, Tetteh-Kumah A, Otoo S, Post RJet al., 2016, Onchocerciasis transmission in Ghana: the human blood index of sibling species of the Simulium damnosum complex, Parasites & Vectors, Vol: 9, ISSN: 1756-3305

BackgroundVector-biting behaviour is important for vector-borne disease (VBD) epidemiology. The proportion of blood meals taken on humans (the human blood index, HBI), is a component of the biting rate per vector on humans in VBD transmission models. Humans are the definitive host of Onchocerca volvulus, but the simuliid vectors feed on a range of animals and HBI is a key indicator of the potential for human onchocerciasis transmission. Ghana has a diversity of Simulium damnosum complex members, which are likely to vary in their HBIs, an important consideration for parameterization of onchocerciasis control and elimination models.MethodsHost-seeking and ovipositing S. damnosum (sensu lato) (s.l.) were collected from seven villages in four Ghanaian regions. Taxa were morphologically and molecularly identified. Blood meals from individually stored blackfly abdomens were used for DNA profiling, to identify previous host choice. Household, domestic animal, wild mammal and bird surveys were performed to estimate the density and diversity of potential blood hosts of blackflies.ResultsA total of 11,107 abdomens of simuliid females (which would have obtained blood meal(s) previously) were tested, with blood meals successfully amplified in 3,772 (34 %). A single-host species was identified in 2,857 (75.7 %) of the blood meals, of which 2,162 (75.7 %) were human. Simulium soubrense Beffa form, S. squamosum C and S. sanctipauli Pra form were the most anthropophagic (HBI = 0.92, 0.86 and 0.70, respectively); S. squamosum E, S. yahense and S. damnosum (sensu stricto) (s.s.)/S. sirbanum were the most zoophagic (HBI = 0.44, 0.53 and 0.63, respectively). The degree of anthropophagy decreased (but not statistically significantly) with increasing ratio of non-human/human blood hosts. Vector to human ratios ranged from 139 to 1,198 blackflies/person.ConclusionsDNA profiling can successfully identify blood meals from host-seeking and ovipositing blackflies.

Journal article

Crellen T, Walker M, Cotton JA, Lamberton PHL, Webster JP, Tukahebwa EM, Kabatereine NBet al., 2016, Reduced efficacy of praziquantel against Schistosoma mansoni is associated with multiple-rounds of mass drug administration, Clinical Infectious Diseases, Vol: 63, Pages: 1151-1159, ISSN: 1537-6591

The efficacy of praziquantel against Schistosoma mansoni was significantly lower in Ugandan schools that had received more prior rounds of mass drug administration, as determined by fitting a statistical model to parasite egg counts before and after treatment.

Journal article

Lamberton PHL, Jourdan PM, 2015, Human Ascariasis: Diagnostics Update, Current Tropical Medicine Reports, Vol: 2, Pages: 189-200, ISSN: 2196-3045

Soil-transmitted helminths (STHs) infect over one billion people worldwide. Ascariasis may mimic a number of conditions, and individual clinical diagnosis often requires a thorough work-up. Kato-Katz thick smears are the standard detection method for Ascaris and, despite low sensitivity, are often used for mapping and monitoring and evaluation of national control programmes. Although increased sampling (number of stools) and diagnostic (number of examinations per stool) efforts can improve sensitivity, Kato-Katz is less sensitive than other microscopy methods such as FLOTAC®. Antibody-based diagnostics may be a sensitive diagnostic tool; however, their usefulness is limited to assessing transmission in areas aiming for elimination. Molecular diagnostics are highly sensitive and specific, but high costs limit their use to individual diagnosis, drug - efficacy studies and identification of Ascaris suum. Increased investments in research on Ascaris and other STHs are urgently required for the development of diagnostic assays to support efforts to reduce human suffering caused by these infections.

Journal article

Gao Y-M, Lu D-B, Ding H, Lamberton PHLet al., 2015, Detecting genotyping errors at Schistosoma japonicum microsatellites with pedigree information, Parasites & Vectors, Vol: 8, ISSN: 1756-3305

Background: Schistosomiasis japonica remains a major public health problem in China. Integrating molecularanalyses, such as population genetic analyses, of the parasite into the on-going surveillance programs is helpful inexploring the factors causing the persistence and/or spread of Schistosoma japonicum. However, genotyping errorscan seriously affect the results of such studies, unless accounted for in the analyses.Methods: We assessed the genotyping errors (missing alleles or false alleles) of seven S. japonicum microsatellites,using a pedigree data approach for schistosome miracidia, which were stored on Whatman FTA cards.Results: Among 107 schistosome miracidia successfully genotyped, resulting in a total of 715 loci calls, a total of 31genotyping errors were observed with 25.2 % of the miracidia having at least one error. The error rate per locusdiffered among loci, which ranged from 0 to 9.8 %, with the mean error rate 4.3 % over loci. With the parentageanalysis software Cervus, the assignment power with these seven markers was estimated to be 89.5 % for oneparent and 99.9 % for a parent pair. One locus was inferred to have a high number of null alleles and a secondwith a high mistyping rate.Conclusion: To the authors’ knowledge, this is the first time that S. japonicum pedigrees have been used in anassessment of genotyping errors of microsatellite markers. The observed locus-specific error rate will benefitdownstream epidemiological or ecological analyses of S. japonicum with the markers.

Journal article

Webster JP, Lamberton PHL, McConkey GA, 2015, The Toxoplasma gondii model of schizophrenia., Handbook of Behavioral Neuroscience Series. Modeling the psychopathological dimensions of schizophrenia and related psychoses: from molecules to behavior., Editors: Pletnikov, Waddington, Publisher: Elsevier, Pages: 225-241

Book chapter

Lamberton PHL, Cheke RA, Winskill P, Tirados I, Walker M, Osei-Atweneboana MY, Biritwum N-K, Tetteh-Kumah A, Boakye DA, Wilson MD, Post RJ, Basanez Met al., 2015, Onchocerciasis Transmission in Ghana: Persistence under Different Control Strategies and the Role of the Simuliid Vectors, PLOS Neglected Tropical Diseases, Vol: 9, ISSN: 1935-2735

Journal article

Cheke RA, Basanez M-G, Perry M, White MT, Garms R, Obuobie E, Lamberton PHL, Young S, Osei-Atweneboana MY, Intsiful J, Shen M, Boakye DA, Wilson MDet al., 2015, Potential effects of warmer worms and vectors on onchocerciasis transmission in West Africa, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 370, ISSN: 0962-8436

Journal article

Bian CR, Gao YM, Lamberton PH, Lu DBet al., 2015, Comparison of genetic diversity and population structure between two Schistosoma japonicum isolates-the field and the laboratory., Parasitology Research, ISSN: 1432-1955

Schistosomiasis japonicum is one of the most important human parasitic diseases, and a number of studies have recently elucidated the difference in biological characteristics of S. japonicum among different parasite isolates, for example, between the field and the laboratory isolates. Therefore, the understanding of underlying genetic mechanism is of both theoretical and practical importance. In this study, we used six microsatellite markers to assess genetic diversity, population structure, and the bottleneck effect (a sharp reduction in population size) of two parasite populations, one field and one laboratory. A total of 136 S. japonicum cercariae from the field and 86 from the laboratory, which were genetically unique within single snails, were analyzed. The results showed bigger numbers of alleles and higher allelic richness in the field parasite population than in the laboratory indicating lower genetic diversity in the laboratory parasites. A bottleneck effect was detected in the laboratory population. When the field and laboratory isolates were combined, there was a clear distinction between two parasite populations using the software Structure. These genetic differences may partially explain the previously observed contrasted biological traits.

Journal article

Ochodo EA, Golalakrishna G, Speak B, Reitsma JB, van Leishout L, Polman K, Lamberton PHL, Bossuyt PMM, Leeflang MMGet al., 2015, Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas, Cochrane Database of Systematic Reviews, ISSN: 1469-493X

Journal article

Cheke RA, Basanez MG, Perry M, White MT, Garms R, Obuobie E, Lamberton PH, Young S, Osei-Atweneboana M, Intsiful J, Shen M, Boakye DA, Wilson Met al., 2015, Potential effects of warmer worms and vectors on onchocerciasis transmission in West Africa, Philosophical Transactions of the Royal Society B: Biological Sciences, ISSN: 1471-2970

Journal article

Lamberton PHL, Crellen T, Cotton JA, Webster JPet al., 2015, Modelling the Effects of Mass Drug Administration on the Molecular Epidemiology of Schistosomes, Advances in Parasitology, Vol: 87, Pages: 293-327, ISSN: 0065-308X

As national governments scale up mass drug administration (MDA) programs aimed to combat neglected tropical diseases (NTDs), novel selection pressures on these parasites increase. To understand how parasite populations are affected by MDA and how to maximize the success of control programmes, it is imperative for epidemiological, molecular and mathematical modelling approaches to be combined. Modelling of parasite population genetic and genomic structure, particularly of the NTDs, has been limited through the availability of only a few molecular markers to date. The landscape of infectious disease research is being dramatically reshaped by next-generation sequencing technologies and our understanding of how repeated selective pressures are shaping parasite populations is radically altering. Genomics can provide high-resolution data on parasite population structure, and identify how loci may contribute to key phenotypes such as virulence and/or drug resistance. We discuss the incorporation of genetic and genomic data, focussing on the recently sequenced Schistosoma spp., into novel mathematical transmission models to inform our understanding of the impact of MDA and other control methods. We summarize what is known to date, the models that exist and how population genetics has given us an understanding of the effects of MDA on the parasites. We consider how genetic and genomic data have the potential to shape future research, highlighting key areas where data are lacking, and how future molecular epidemiology knowledge can aid understanding of transmission dynamics and the effects of MDA, ultimately informing public health policy makers of the best interventions for NTDs.

Journal article

Bian CR, Lu DB, Su J, Zhou X, Zhuge HX, Lamberton PHet al., 2015, Serological Prevalence of Schistosoma japonicum in Mobile Populations in Previously Endemic but Now Non-Endemic Regions of China: A Systematic Review and Meta-Analysis., PLOS One, Vol: 10, ISSN: 1932-6203

BACKGROUND: Schistosomiasis japonica has been resurging in certain areas of China where its transmission was previously well controlled or interrupted. Several factors may be contributing to this, including mobile populations, which if infected, may spread the disease. A wide range of estimates have been published for S. japonicum infections in mobile populations, and a synthesis of these data will elucidate the relative risk presented from these groups. METHODS: A literature search for publications up to Oct 31, 2014 on S. japonicum infection in mobile populations in previously endemic but now non-endemic regions was conducted using four bibliographic databases: China National Knowledge Infrastructure, WanFang, VIP Chinese Journal Databases, and PubMed. A meta-analysis was conducted by pooling one arm binary data with MetaAnalyst Beta 3.13. The protocol is available on PROSPERO (No. CRD42013005967). RESULTS: A total of 41 studies in Chinese met the inclusion criteria, covering seven provinces of China. The time of post-interruption surveillance ranged from the first year to the 31st year. After employing a random-effects model, from 1992 to 2013 the pooled seroprevalence ranged from 0.9% (95% CI: 0.5-1.6%) in 2003 to 2.3% (95% CI: 1.5-3.4) in 1995; from the first year after the disease had been interrupted to the 31st year, the pooled seroprevalence ranged from 0.6% (95% CI: 0.2-2.1%) in the 27th year to 4.0% (95%CI: 1.3-11.3%) in the second year. The pooled seroprevalence in mobile populations each year was significantly lower than among the residents of endemic regions, whilst four papers reported a lower level of infection in the mobile populations than in the local residents out of only 13 papers which included this data. CONCLUSIONS: The re-emergence of S. japonicum in areas which had previously interrupted transmission might be due to other factors, although risk from re-introduction from mobile populations could not be excluded.

Journal article

Lamberton PHL, Cheke RA, Walker M, Winskill P, Osei-Atweneboana MY, Tirados I, Tetteh-Kumah A, Boakye DA, Wilson MD, Post RJ, Basanez M-Get al., 2014, Onchocerciasis transmission in Ghana: biting and parous rates of host-seeking sibling species of the Simulium damnosum complex, PARASITES & VECTORS, Vol: 7, ISSN: 1756-3305

Journal article

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