Imperial College London
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DrPoppyLamberton

Faculty of Medicine, School of Public Health

Honorary Senior Lecturer
 
 
 
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poppy.lamberton CV

 
 
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Location

 

Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bian:2015:10.1007/s00436-015-4433-z,
author = {Bian, CR and Gao, YM and Lamberton, PH and Lu, DB},
doi = {10.1007/s00436-015-4433-z},
journal = {Parasitology Research},
title = {Comparison of genetic diversity and population structure between two Schistosoma japonicum isolates-the field and the laboratory.},
url = {http://dx.doi.org/10.1007/s00436-015-4433-z},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Schistosomiasis japonicum is one of the most important human parasitic diseases, and a number of studies have recently elucidated the difference in biological characteristics of S. japonicum among different parasite isolates, for example, between the field and the laboratory isolates. Therefore, the understanding of underlying genetic mechanism is of both theoretical and practical importance. In this study, we used six microsatellite markers to assess genetic diversity, population structure, and the bottleneck effect (a sharp reduction in population size) of two parasite populations, one field and one laboratory. A total of 136 S. japonicum cercariae from the field and 86 from the laboratory, which were genetically unique within single snails, were analyzed. The results showed bigger numbers of alleles and higher allelic richness in the field parasite population than in the laboratory indicating lower genetic diversity in the laboratory parasites. A bottleneck effect was detected in the laboratory population. When the field and laboratory isolates were combined, there was a clear distinction between two parasite populations using the software Structure. These genetic differences may partially explain the previously observed contrasted biological traits.
AU  - Bian,CR
AU  - Gao,YM
AU  - Lamberton,PH
AU  - Lu,DB
DO  - 10.1007/s00436-015-4433-z
PY  - 2015///
SN  - 1432-1955
TI  - Comparison of genetic diversity and population structure between two Schistosoma japonicum isolates-the field and the laboratory.
T2  - Parasitology Research
UR  - http://dx.doi.org/10.1007/s00436-015-4433-z
UR  - http://www.ncbi.nlm.nih.gov/pubmed/25804973
ER  -
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