Imperial College London
Alternate

DrPoppyLamberton

Faculty of Medicine, School of Public Health

Honorary Senior Lecturer
 
 
 
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poppy.lamberton CV

 
 
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Location

 

Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Prada:2018:10.1186/s13071-017-2580-z,
author = {Prada, JM and Touloupou, P and Adriko, M and Tukahebwa, EM and Lamberton, PHL and Hollingsworth, TD},
doi = {10.1186/s13071-017-2580-z},
journal = {Parasites & Vectors},
title = {Understanding the relationship between egg- and antigen-based diagnostics of Schistosoma mansoni infection pre- and post-treatment in Uganda.},
url = {http://dx.doi.org/10.1186/s13071-017-2580-z},
volume = {11},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Schistosomiasis is a major socio-economic and public health problem in many sub-Saharan African countries. After large mass drug administration (MDA) campaigns, prevalence of infection rapidly returns to pre-treatment levels. The traditional egg-based diagnostic for schistosome infections, Kato-Katz, is being substituted in many settings by circulating antigen recognition-based diagnostics, usually the point-of-care circulating cathodic antigen test (CCA). The relationship between these diagnostics is poorly understood, particularly after treatment in both drug-efficacy studies and routine monitoring. RESULTS: We created a model of schistosome infections to better understand and quantify the relationship between these two egg- and adult worm antigen-based diagnostics. We focused particularly on the interpretation of "trace" results after CCA testing. Our analyses suggest that CCA is generally a better predictor of prevalence, particularly after treatment, and that trace CCA results are typically associated with truly infected individuals. CONCLUSIONS: Even though prevalence rises to pre-treatment levels only six months after MDAs, our model suggests that the average intensity of infection is much lower, and is probably in part due to a small burden of surviving juveniles from when the treatment occurred. This work helps to better understand CCA diagnostics and the interpretation of post-treatment prevalence estimations.
AU  - Prada,JM
AU  - Touloupou,P
AU  - Adriko,M
AU  - Tukahebwa,EM
AU  - Lamberton,PHL
AU  - Hollingsworth,TD
DO  - 10.1186/s13071-017-2580-z
PY  - 2018///
SN  - 1756-3305
TI  - Understanding the relationship between egg- and antigen-based diagnostics of Schistosoma mansoni infection pre- and post-treatment in Uganda.
T2  - Parasites & Vectors
UR  - http://dx.doi.org/10.1186/s13071-017-2580-z
UR  - http://hdl.handle.net/10044/1/56161
VL  - 11
ER  -
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