Imperial College London
Alternate

DrPrashantSrivastava

Faculty of Medicine, National Heart & Lung Institute

Lecturer in Cardiovascular Bioinformatics and Medical Statis
 
 
 
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Contact

 

prashant.srivastava

 
 
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Location

 

337ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kang:2014:10.1016/j.celrep.2014.07.032,
author = {Kang, H and Kerloc'h, A and Rotival, M and Xu, X and Zhang, Q and D'Souza, Z and Kim, M and Scholz, JC and Ko, J-H and Srivastava, PK and Genzen, JR and Cui, W and Aitman, TJ and Game, L and Melvin, JE and Hanidu, A and Dimock, J and Zheng, J and Souza, D and Behera, AK and Nabozny, G and Cook, HT and Bassett, JHD and Williams, GR and Li, J and Vignery, A and Petretto, E and Behmoaras, J},
doi = {10.1016/j.celrep.2014.07.032},
journal = {Cell Reports},
pages = {1210--1224},
title = {Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease},
url = {http://dx.doi.org/10.1016/j.celrep.2014.07.032},
volume = {8},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Macrophages can fuse to form osteoclasts in boneor multinucleate giant cells (MGCs) as part of theimmune response. We use a systems geneticsapproach in rat macrophages to unravel their geneticdeterminants of multinucleation and investigate theirrole in both bone homeostasis and inflammatory disease.We identify a trans-regulated gene networkassociated with macrophage multinucleation andKcnn4 as being the most significantly trans-regulatedgene in the network and induced at the onsetof fusion. Kcnn4 is required for osteoclast andMGC formation in rodents and humans. Geneticdeletion of Kcnn4 reduces macrophage multinucleationthrough modulation of Ca2+ signaling, increasesbone mass, and improves clinical outcomein arthritis. Pharmacological blockade of Kcnn4reduces experimental glomerulonephritis. Our dataimplicate Kcnn4 in macrophage multinucleation,identifying it as a potential therapeutic target for inhibitionof bone resorption and chronic inflammation.
AU  - Kang,H
AU  - Kerloc'h,A
AU  - Rotival,M
AU  - Xu,X
AU  - Zhang,Q
AU  - D'Souza,Z
AU  - Kim,M
AU  - Scholz,JC
AU  - Ko,J-H
AU  - Srivastava,PK
AU  - Genzen,JR
AU  - Cui,W
AU  - Aitman,TJ
AU  - Game,L
AU  - Melvin,JE
AU  - Hanidu,A
AU  - Dimock,J
AU  - Zheng,J
AU  - Souza,D
AU  - Behera,AK
AU  - Nabozny,G
AU  - Cook,HT
AU  - Bassett,JHD
AU  - Williams,GR
AU  - Li,J
AU  - Vignery,A
AU  - Petretto,E
AU  - Behmoaras,J
DO  - 10.1016/j.celrep.2014.07.032
EP  - 1224
PY  - 2014///
SN  - 2211-1247
SP  - 1210
TI  - Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2014.07.032
UR  - https://www.sciencedirect.com/science/article/pii/S2211124714006160?via%3Dihub
UR  - http://hdl.handle.net/10044/1/24455
VL  - 8
ER  -
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