Imperial College London
Alternate

Dr Qadeer Arshad

Faculty of Medicine, Faculty of Medicine Centre

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 5527q.arshad

 
 
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Location

 

Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Arshad:2023:10.1016/j.jns.2023.120579,
author = {Arshad, Q and Cousins, S and Golding, JF and Bronstein, AM},
doi = {10.1016/j.jns.2023.120579},
journal = {Journal of the Neurological Sciences},
pages = {1--7},
title = {Factors influencing clinical outcome in vestibular neuritis – A focussed review and reanalysis of prospective data},
url = {http://dx.doi.org/10.1016/j.jns.2023.120579},
volume = {446},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Following vestibular neuritis (VN), long term prognosis is not dependent on the magnitude of the residual peripheral function as measured with either caloric or the video head-impulse test. Rather, recovery is determined by a combination of visuo-vestibular (visual dependence), psychological (anxiety) and vestibular perceptual factors. Our recent research in healthy individuals has also revealed a strong association between the degree of lateralisation of vestibulo-cortical processing and gating of vestibular signals, anxiety and visual dependence. In the context of several functional brain changes occurring in the interaction between visual, vestibular and emotional cortices, which underpin the aforementioned psycho-physiological features in patients with VN, we re-examined our previously published findings focusing on additional factors impacting long term clinical outcome and function. These included: (i) the role of concomitant neuro-otological dysfunction (i.e. migraine and benign paroxysmal positional vertigo (BPPV)) and (ii) the degree to which brain lateralisation of vestibulo-cortical processing influences gating of vestibular function in the acute stage. We found that migraine and BPPV interfere with symptomatic recovery following VN. That is, dizziness handicap at short-term recovery stage was significantly predicted by migraine (r = 0.523, n = 28, p = .002), BPPV (r = 0.658, n = 31, p < .001) and acute visual dependency (r = 0.504, n = 28, p = .003). Moreover, dizziness handicap in the long-term recovery stage continued to be predicted by migraine (r = 0.640, n = 22, p = .001), BPPV (r = 0.626, n = 24, p = .001) and acute visual dependency (r = 0.667, n = 22, p < .001). Furthermore, surrogate measures of vestibulo-cortical lateralisation were predictive of the amount of cortical suppression exerted over vestibular thresholds. That is, in right-sided VN patients, we observed a positive correlation between visual dependence and acute ipsilesional ocu
AU  - Arshad,Q
AU  - Cousins,S
AU  - Golding,JF
AU  - Bronstein,AM
DO  - 10.1016/j.jns.2023.120579
EP  - 7
PY  - 2023///
SN  - 0022-510X
SP  - 1
TI  - Factors influencing clinical outcome in vestibular neuritis – A focussed review and reanalysis of prospective data
T2  - Journal of the Neurological Sciences
UR  - http://dx.doi.org/10.1016/j.jns.2023.120579
UR  - https://www.sciencedirect.com/science/article/pii/S0022510X23000394?via%3Dihub
UR  - http://hdl.handle.net/10044/1/103839
VL  - 446
ER  -
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