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@article{Kanagasabai:2022:ajh/hpab141,
author = {Kanagasabai, T and Xie, W and Yan, L and Zhao, L and Carter, E and Guo, D and Chan, Q and Daskalopoulou, S and Elliott, P and Ezzati, M and Yang, X and Xie, G and Kelly, F and Wu, Y and Baumgartner, J},
doi = {ajh/hpab141},
journal = {American Journal of Hypertension},
pages = {121--131},
title = {Household air pollution and blood pressure, vascular damage and sub-clinical indicators of cardiovascular disease in older Chinese adults},
url = {http://dx.doi.org/10.1093/ajh/hpab141},
volume = {35},
year = {2022}
}

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TY  - JOUR
AB  - BackgroundLimited data suggest that household air pollution from cooking and heating with solid fuel (i.e., coal and biomass) stoves may contribute to the development of hypertension and vascular damage.MethodsUsing mixed-effects regression models, we investigated the associations of household air pollution with blood pressure (BP) and vascular function in 753 adults (ages 40-79y) from three diverse provinces in China. We conducted repeated measures of participants’ household fuel use, personal exposure to fine particulate air pollution (PM2.5), BP, brachial-femoral pulse wave velocity (bfPWV), and augmentation index. Ultrasound images of the carotid arteries were obtained to assess intima-media thickness (CIMT) and plaques. Covariate information on socio-demographics, health behaviors, 24-h urinary sodium, and blood lipids was also obtained.ResultsAverage estimated yearly personal exposure to PM2.5 was 97.5 μg/m 3 (SD: 79.2; range: 3.5-1241), and 65% of participants cooked with solid fuel. In multivariable models, current solid fuel use was associated with higher systolic (2.4 mmHg, 95%CI: -0.4, 4.9) and diastolic BP (1.4 mmHg, 95%CI: -0.1, 3.0) and greater total area of plaques (1.7 mm 2, 95%CI: -6.5, 9.8) compared with exclusive use of electricity or gas stoves. A 1-ln(µg/m 3) increase in PM2.5 exposure was associated with higher systolic (1.5 mmHg, 95%CI: 0.2, 2.7) and diastolic BP (1.0 mmHg, 95%CI: 0.4, 1.7) and with greater CIMT (0.02 mm, 95%CI: 0.00, 0.04) and total area of plaques (4.7 mm 2, 95%CI: -2.0, 11.5). We did not find associations with arterial stiffness, except for a lower bfPWV (-1.5 m/s, 95%CI: -3.0, -0.0) among users of solid fuel heaters.ConclusionsThese findings add to limited evidence that household air pollution is associated with higher BP and with greater CIMT and total plaque area.
AU  - Kanagasabai,T
AU  - Xie,W
AU  - Yan,L
AU  - Zhao,L
AU  - Carter,E
AU  - Guo,D
AU  - Chan,Q
AU  - Daskalopoulou,S
AU  - Elliott,P
AU  - Ezzati,M
AU  - Yang,X
AU  - Xie,G
AU  - Kelly,F
AU  - Wu,Y
AU  - Baumgartner,J
DO  - ajh/hpab141
EP  - 131
PY  - 2022///
SN  - 0895-7061
SP  - 121
TI  - Household air pollution and blood pressure, vascular damage and sub-clinical indicators of cardiovascular disease in older Chinese adults
T2  - American Journal of Hypertension
UR  - http://dx.doi.org/10.1093/ajh/hpab141
UR  - https://academic.oup.com/ajh/advance-article/doi/10.1093/ajh/hpab141/6368243
UR  - http://hdl.handle.net/10044/1/91586
VL  - 35
ER  -

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