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@article{Loo:2022:10.1021/acs.jproteome.1c00851,
author = {Loo, RL and Chan, Q and Nicholson, JK and Holmes, E},
doi = {10.1021/acs.jproteome.1c00851},
journal = {Journal of Proteome Research},
pages = {560--589},
title = {Balancing the equation: a natural history of trimethylamine and trimethylamine-N-oxide.},
url = {http://dx.doi.org/10.1021/acs.jproteome.1c00851},
volume = {21},
year = {2022}
}

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TY  - JOUR
AB  - Trimethylamine (TMA) and its N-oxide (TMAO) are ubiquitous in prokaryote and eukaryote organisms as well as in the environment, reflecting their fundamental importance in evolutionary biology, and their diverse biochemical functions. Both metabolites have multiple biological roles including cell-signaling. Much attention has focused on the significance of serum and urinary TMAO in cardiovascular disease risk, yet this is only one of the many facets of a deeper TMA-TMAO partnership that reflects the significance of these metabolites in multiple biological processes spanning animals, plants, bacteria, and fungi. We report on analytical methods for measuring TMA and TMAO and attempt to critically synthesize and map the global functions of TMA and TMAO in a systems biology framework.
AU  - Loo,RL
AU  - Chan,Q
AU  - Nicholson,JK
AU  - Holmes,E
DO  - 10.1021/acs.jproteome.1c00851
EP  - 589
PY  - 2022///
SN  - 1535-3893
SP  - 560
TI  - Balancing the equation: a natural history of trimethylamine and trimethylamine-N-oxide.
T2  - Journal of Proteome Research
UR  - http://dx.doi.org/10.1021/acs.jproteome.1c00851
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35142516
UR  - https://pubs.acs.org/doi/10.1021/acs.jproteome.1c00851
UR  - http://hdl.handle.net/10044/1/96107
VL  - 21
ER  -

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