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@article{Chan:2022:ajcn/nqac067,
author = {Chan, Q and Wren, G and Lau, CH and Ebbels, T and Gibson, R and Loo, RL and Aljuraiban, G and Posma, J and Dyer, A and Steffen, L and Rodriguez, B and Appel, L and Daviglus, M and Elliott, P and Stamler, J and Holmes, E and Van, Horn L},
doi = {ajcn/nqac067},
journal = {The American Journal of Clinical Nutrition},
pages = {216--229},
title = {Blood pressure interactions with the DASH dietary pattern, sodium, and potassium: The International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP)},
url = {http://dx.doi.org/10.1093/ajcn/nqac067},
volume = {116},
year = {2022}
}

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TY  - JOUR
AB  - BackgroundAdherence to the Dietary Approaches to Stop Hypertension (DASH) diet enhances potassium intake and reduces sodium intake and blood pressure (BP), but the underlying metabolic pathways are unclear.ObjectiveAmong free-living populations, delineate metabolic signatures associated with the DASH diet adherence, 24-hr urinary sodium and potassium excretions and the potential metabolic pathways involved.Design24-hr urinary metabolic profiling by proton nuclear magnetic resonance spectroscopy was used to characterize the metabolic signatures associated with the DASH dietary pattern score (DASH score) and 24-hr excretion of sodium and potassium among participants in the United States (n=2,164) and United Kingdom (n= 496) enrolled in the International Study of Macro- and Micronutrients and Blood Pressure (INTERMAP). Multiple linear regression and cross-tabulation analyses were used to investigate the DASH-BP relation and its modulation by sodium and potassium. Potential pathways associated with DASH adherence, sodium and potassium excretion, and BP were identified using mediation analyses and metabolic reaction networks.ResultsAdherence to DASH diet was associated with urinary potassium excretion (correlation coefficient, r = 0.42, P<0.0001). In multivariable regression analyses, a five-point higher DASH score (range 7 to 35) was associated with a lower systolic BP by 1.35 mmHg (95% confidence interval: -1.95, -0.80, P=1.2 × 10−5); control of the model for potassium but not sodium attenuated the DASH-BP relation. Two common metabolites (hippurate and citrate) mediated the potassium-BP and DASH-BP relationships, while five metabolites (succinate, alanine, S-methyl cysteine sulfoxide, 4-hydroxyhippurate, phenylacetylglutamine) were found specific to the DASH-BP relation.ConclusionsGreater adherence to DASH diet is associated with lower BP and higher potassium intake across levels of sodium intake. The DASH diet recommends greater intake of fruits, veget
AU  - Chan,Q
AU  - Wren,G
AU  - Lau,CH
AU  - Ebbels,T
AU  - Gibson,R
AU  - Loo,RL
AU  - Aljuraiban,G
AU  - Posma,J
AU  - Dyer,A
AU  - Steffen,L
AU  - Rodriguez,B
AU  - Appel,L
AU  - Daviglus,M
AU  - Elliott,P
AU  - Stamler,J
AU  - Holmes,E
AU  - Van,Horn L
DO  - ajcn/nqac067
EP  - 229
PY  - 2022///
SN  - 1938-3207
SP  - 216
TI  - Blood pressure interactions with the DASH dietary pattern, sodium, and potassium: The International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP)
T2  - The American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.1093/ajcn/nqac067
UR  - https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqac067/6548184
UR  - http://hdl.handle.net/10044/1/95823
VL  - 116
ER  -

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