Imperial College London
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DrRashaAl-Lamee

Faculty of Medicine, National Heart & Lung Institute

Clinical Reader in Cardiovascular Science
 
 
 
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r.al-lamee13

 
 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mikhail:2021:10.1136/openhrt-2020-001472,
author = {Mikhail, G and Khawaja, SA and Mohan, P and Jabbour, R and Bampouri, T and Bowsher, G and Hassan, AMM and Huq, F and Baghdasaryan, L and Wang, B and Sethi, A and Sen, S and Petraco, R and Ruparelia, N and Nijjer, S and Malik, IS and Foale, R and Bellamy, M and Kooner, J and Rana, BS and Cole, G and Sutaria, N and Kanaganayagam, G and Nihoyannopoulos, P and Fox, K and Plymen, CM and Pabari, P and Howard, L and Davies, R and Hajoi, G and Lo, Giudice F and Kanagaratnam, P and Anderson, J and Chukwuemeka, A and Khamis, R and Varnava, A and Baker, CSR and Francis, D and Asaria, P and Al-Lamee, R},
doi = {10.1136/openhrt-2020-001472},
journal = {Open Heart},
pages = {1--9},
title = {COVID-19 and its impact on the cardiovascular system},
url = {http://dx.doi.org/10.1136/openhrt-2020-001472},
volume = {8},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives: The clinical impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development of cardiovascular complications in the initial cohort of SARS-CoV-2 positive patients at Imperial College Healthcare NHS Trust, United Kingdom.Methods: We retrospectively analysed 498 COVID-19 positive adult admissions to our institute from 7th March to 7th April 2020. Patient data was collected for baseline demographics, co-morbidities and in-hospital outcomes, especially relating to cardiovascular intervention.Results:Mean age was 67.4±16.1 years and 62.2%(n=310) were male.  64.1%(n=319) of our cohort had underlying cardiovascular disease (CVD) with 53.4%(n=266) having hypertension. 43.2%(n=215) developed acute myocardial injury. Mortality was significantly increased in those patients with myocardial injury (47.4% vs 18.4%,p<0.001).  Only 4 COVID-19 patients had invasive coronary angiography,2 underwent percutaneous coronary intervention and 1 required a permanent pacemaker implantation. 7.0%(n=35) of patients had an inpatient echocardiogram.  Acute myocardial injury (OR 2.39,1.31-4.40,p=0.005) and history of hypertension (OR 1.88 ,1.01-3.55,p=0.049) approximately doubled the odds of in-hospital mortality in patients admitted with COVID-19 after other variables had been controlled for.Conclusion:Hypertension, pre-existing CVD and acute myocardial injury were associated with increased in-hospital mortality in our cohort of COVID-19 patients. However, only a low number of patients required invasive cardiac intervention.
AU  - Mikhail,G
AU  - Khawaja,SA
AU  - Mohan,P
AU  - Jabbour,R
AU  - Bampouri,T
AU  - Bowsher,G
AU  - Hassan,AMM
AU  - Huq,F
AU  - Baghdasaryan,L
AU  - Wang,B
AU  - Sethi,A
AU  - Sen,S
AU  - Petraco,R
AU  - Ruparelia,N
AU  - Nijjer,S
AU  - Malik,IS
AU  - Foale,R
AU  - Bellamy,M
AU  - Kooner,J
AU  - Rana,BS
AU  - Cole,G
AU  - Sutaria,N
AU  - Kanaganayagam,G
AU  - Nihoyannopoulos,P
AU  - Fox,K
AU  - Plymen,CM
AU  - Pabari,P
AU  - Howard,L
AU  - Davies,R
AU  - Hajoi,G
AU  - Lo,Giudice F
AU  - Kanagaratnam,P
AU  - Anderson,J
AU  - Chukwuemeka,A
AU  - Khamis,R
AU  - Varnava,A
AU  - Baker,CSR
AU  - Francis,D
AU  - Asaria,P
AU  - Al-Lamee,R
DO  - 10.1136/openhrt-2020-001472
EP  - 9
PY  - 2021///
SN  - 2053-3624
SP  - 1
TI  - COVID-19 and its impact on the cardiovascular system
T2  - Open Heart
UR  - http://dx.doi.org/10.1136/openhrt-2020-001472
UR  - https://openheart.bmj.com/content/8/1/e001472
UR  - http://hdl.handle.net/10044/1/86254
VL  - 8
ER  -
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