Rachael is a Research Associate at the MRC CMBI, Department of Life Sciences.
After graduating with a Bachelor of Science with first class Honours from the University of Queensland, Rachael worked as a Research Assistant at the Diamantina Institute/TRI in a laboratory of Dr Fiona Simpson studying EGFR trafficking in squamous cell carcinoma. In 2011, she began her PhD in Cell Biology with Professor Pascal Meier at the Institute of Cancer Research, London. Here she studied the regulation of cell death and inflammation pathways via post-translational modifications and identified a SUMOylation as a novel regulator of the NLRP3 inflammasome. In 2016, Rachael joined the laboratory of Prof. Gad Frankel at Imperial College. She uses the mouse pathogen C. rodentium to understand mechanisms driving colitis caused by the human pathogens enterohaemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) and inflammatory bowel disease.
et al., 2020, Citrobacter rodentium induces rapid and unique metabolic and inflammatory responses in mice suffering from severe disease, Cellular Microbiology, Vol:22, ISSN:1462-5814, Pages:1-17
et al., 2019, Faecal neutrophil elastase-antiprotease balance reflects colitis severity, Mucosal Immunology, ISSN:1933-0219
et al., 2019, Citrobacter rodentium-host-microbiota interactions: immunity, bioenergetics and metabolism, Nature Reviews Microbiology, Vol:17, ISSN:1740-1526, Pages:701-715
et al., 2019, An Ex Vivo Human Tumor Assay Shows Distinct Patterns of EGFR Trafficking in Squamous Cell Carcinoma Correlating to Therapeutic Outcomes, Journal of Investigative Dermatology, Vol:139, ISSN:0022-202X, Pages:213-223
et al., 2018, SUMO-mediated regulation of NLRP3 modulates inflammasome activity, Nature Communications, Vol:9, ISSN:2041-1723