Imperial College London
Alternate

Dr Richard H. Barton

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3014r.barton Website

 
 
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Location

 

SAFB 660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moreno-Navarrete:2017:10.1002/mnfr.201700721,
author = {Moreno-Navarrete, JM and Serino, M and Blasco-Baque, V and Azalbert, V and Barton, RH and Cardellini, M and Latorre, J and Ortega, F and Sabater-Masdeu, M and Burcelin, R and Dumas, M-E and Ricart, W and Federici, M and Fernández-Real, JM},
doi = {10.1002/mnfr.201700721},
journal = {Molecular Nutrition and Food Research},
title = {Gut microbiota interacts with markers of adipose tissue Browning, insulin action and plasma acetate in morbid obesity},
url = {http://dx.doi.org/10.1002/mnfr.201700721},
volume = {62},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - SCOPE: To examine the potential relationship among gene expression markers of adipose tissue browning, gut microbiota, and insulin sensitivity in humans. METHODS AND RESULTS: Gut microbiota composition and gene markers of browning are analyzed in subcutaneous (SAT) and visceral (VAT) adipose tissue from morbidly obese subjects (n = 34). Plasma acetate is measured through 1 H NMR and insulin sensitivity using euglycemic hyperinsulinemic clamp. Subjects with insulin resistance show an increase in the relative abundance (RA) of the phyla Bacteroidetes and Proteobacteria while RA of Firmicutes is decreased. In all subjects, Firmicutes RA is negatively correlated with HbA1c and fasting triglycerides, whereas Proteobacteria RA was negatively correlated with insulin sensitivity. Firmicutes RA is positively associated with markers of brown adipocytes (PRDM16, UCP1, and DIO2) in SAT, but not in VAT. Multivariate regression analysis indicates that Firmicutes RA contributes significantly to SAT PRDM16, UCP1, and DIO2 mRNA variance after controlling for age, BMI, HbA1c , or insulin sensitivity. Interestingly, Firmicutes RA, specifically those bacteria belonging to the Ruminococcaceae family, is positively associated with plasma acetate levels, which are also linked to SAT PRDM16 mRNA and insulin sensitivity. CONCLUSION: Gut microbiota composition is linked to adipose tissue browning and insulin action in morbidly obese subjects, possibly through circulating acetate.
AU  - Moreno-Navarrete,JM
AU  - Serino,M
AU  - Blasco-Baque,V
AU  - Azalbert,V
AU  - Barton,RH
AU  - Cardellini,M
AU  - Latorre,J
AU  - Ortega,F
AU  - Sabater-Masdeu,M
AU  - Burcelin,R
AU  - Dumas,M-E
AU  - Ricart,W
AU  - Federici,M
AU  - Fernández-Real,JM
DO  - 10.1002/mnfr.201700721
PY  - 2017///
SN  - 1613-4125
TI  - Gut microbiota interacts with markers of adipose tissue Browning, insulin action and plasma acetate in morbid obesity
T2  - Molecular Nutrition and Food Research
UR  - http://dx.doi.org/10.1002/mnfr.201700721
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29105287
UR  - http://hdl.handle.net/10044/1/57427
VL  - 62
ER  -
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