Publications
375 results found
Chow L, Munblit D, Dissanayeke S, et al., 2012, Soluble CD14 and hepatocyte growth factor in human colostrum of atopic and non-atopic mothers, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1842-1843, ISSN: 0954-7894
Davies CL, Boyle RJ, Gore C, et al., 2012, The Prevalence of de Novo Food Allergy in Paediatric Renal Transplant Recipients, TRANSPLANTATION, Vol: 94, Pages: 906-906, ISSN: 0041-1337
Fiocchi A, Burks W, Bahna SL, et al., 2012, Clinical use of probiotics in pediatric allergy (cuppa): a World Allergy Organization position paper, World Allergy Organization Journal, Vol: 5, Pages: 148-167, ISSN: 1939-4551
BACKGROUND: : Probiotic administration has been proposed for the prevention and treatment of specific allergic manifestations such as eczema, rhinitis, gastrointestinal allergy, food allergy, and asthma. However, published statements and scientific opinions disagree about the clinical usefulness. OBJECTIVE: : A World Allergy Organization Special Committee on Food Allergy and Nutrition review of the evidence regarding the use of probiotics for the prevention and treatment of allergy. METHODS: : A qualitative and narrative review of the literature on probiotic treatment of allergic disease was carried out to address the diversity and variable quality of relevant studies. This variability precluded systematization, and an expert panel group discussion method was used to evaluate the literature. In the absence of systematic reviews of treatment, meta-analyses of prevention studies were used to provide data in support of probiotic applications. RESULTS: : Despite the plethora of literature, probiotic research is still in its infancy. There is a need for basic microbiology research on the resident human microbiota. Mechanistic studies from biology, immunology, and genetics are needed before we can claim to harness the potential of immune modulatory effects of microbiota. Meanwhile, clinicians must take a step back and try to link disease state with alterations of the microbiota through well-controlled long-term studies to identify clinical indications. CONCLUSIONS: : Probiotics do not have an established role in the prevention or treatment of allergy. No single probiotic supplement or class of supplements has been demonstrated to efficiently influence the course of any allergic manifestation or long-term disease or to be sufficient to do so. Further epidemiologic, immunologic, microbiologic, genetic, and clinical studies are necessary to determine whether probiotic supplements will be useful in preventing allergy. Until then, supplementation with probiotics remains empiri
Boyle R, Elremeli M, Cherry M, et al., 2012, Venom immunotherapy for preventing allergic reactions to insect stings: a systematic review and health economic analysis, 31st Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY-BLACKWELL, Pages: 222-222, ISSN: 0105-4538
Fernandes B, Boyle R, Gore C, et al., 2012, Food protein-induced enterocolitis syndrome can occur in adults - a case report confirmed by supervised food challenge, 31st Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY-BLACKWELL, Pages: 212-212, ISSN: 0105-4538
Fernandes BN, Boyle RJ, Gore C, et al., 2012, Food protein-induced enterocolitis syndrome can occur in adults, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 130, Pages: 1199-1200, ISSN: 0091-6749
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- Citations: 87
Ismail IH, Oppedisano F, Joseph SJ, et al., 2012, Reduced gut microbial diversity in early life is associated with later development of eczema but not atopy in high-risk infants, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 23, Pages: 674-681, ISSN: 0905-6157
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- Citations: 131
Ismail IH, Boyle RJ, Tang ML, 2012, INFANTS WHO DEVELOP ECZEMA AT 12 MONTHS HAVE A DEFICIENT T REGULATORY CELL RESPONSE TO MICROBIAL STIMULI AT THE TIME OF BIRTH, 15th Biennial Meeting European-Society-for-Immunodeficiency (ESID), Publisher: SPRINGER/PLENUM PUBLISHERS, Pages: 404-404, ISSN: 0271-9142
Davies CL, Gore C, Boyle RJ, et al., 2012, The Prevalence Of De Novo Food Allergy In Paediatric Renal Transplant Recipients, PEDIATRIC NEPHROLOGY, Vol: 27, Pages: 1632-1632, ISSN: 0931-041X
Waterfield T, Warner JO, Boyle RJ, 2012, Is atopy the common factor mediating changes in the prevalence of different allergic diseases?, ALLERGOLOGIA ET IMMUNOPATHOLOGIA, Vol: 40, Pages: 265-266, ISSN: 0301-0546
Kuitunen M, Boyle RJ, 2012, Probiotics for the prevention of allergic disease, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 42, Pages: 991-993, ISSN: 0954-7894
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- Citations: 4
Ismail IH, Oppedisano F, Joseph SJ, et al., 2012, Prenatal administration of Lactobacillus rhamnosus has no effect on the diversity of the early infant gut microbiota., Pediatr Allergy Immunol, Vol: 23, Pages: 255-258
We have recently shown that maternal administration of Lactobacillus rhamnosus GG (LGG) during late pregnancy can have beneficial effects on the early development of infant gut microbiota, promoting a bifidobacteria profile similar to that of a healthy breastfed infant. It is uncertain, however, whether such probiotic supplementation could influence the diversity of infant gut microbiota. We investigated the effect of pre-natal LGG on gut microbial diversity in the early post-natal period. Day-7 faecal samples were collected from 98 infants at high risk of allergic disease, whose mothers participated in a pre-natal probiotic eczema prevention study. Faecal microbial diversity was assessed by terminal restriction fragment length polymorphism using restriction enzymes Sau96I and AluI. A greater number of peaks represent greater diversity of bacterial communities. Administration of LGG to mothers during late pregnancy had no effects on the mean number of peaks in faecal samples from 1-wk-old infants as compared to placebo (AluI 14.4 vs. 15.5, p = 0.17, 95% CI -0.4, 2.5; Sau96I 17.3 vs. 15.8, p = 0.15, 95% CI -3.5, 0.5). Prenatal LGG failed to modulate diversity of early infant gut microbiota despite promoting a beneficial bifidobacteria profile.
Hockenhull J, Elremeli M, Cherry MG, et al., 2012, A systematic review of the clinical effectiveness and cost-effectiveness of Pharmalgen® for the treatment of bee and wasp venom allergy, Health Technology Assessment, Vol: 16, Pages: 1-110
Boyle RJ, Elremeli M, Hockenhull J, et al., 2012, Venom immunotherapy for preventing allergic reactions to insect stings, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X
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- Citations: 138
Munblit D, Boyle RJ, 2012, Modulating breast milk composition - the key to allergy prevention?, International Archives of Allergy and Immunology, Vol: 159, Pages: 107-108
Menikou S, Patel MP, Rose KL, et al., 2012, Relationship between complotype and severity of reported systemic allergic reactions to peanut, Journal of Allergy and Clinical Immunology, Vol: 129, Pages: 1398-1401
Goldring S, Warner JO, Shaheen SO, et al., 2011, Early life vitamin D status and lung development, Current Respiratory Medicine Reviews, Vol: 7, Pages: 396-403, ISSN: 1573-398X
There is evidence of an association between early life vitamin D insufficiency and future risk of developing asthma. Given the high prevalence of vitamin D insufficiency in women during pregnancy when developmental programming is occurring, this may be of critical public health importance. There are plausible biological mechanisms for an association. Vitamin D is the pro-hormone of calcitriol, a secosteroid hormone with widespread pleiotropic actions. It is a powerful immune modulator and has been shown in animal and in vitro work to have a role in early lung development. Calcitriol may influence lung development through expression of the vitamin D receptor on lung and immune cells, and through epigenetic mechanisms. If the association between early life vitamin D status and childhood respiratory disease is shown to be causal, then this could have significant implications for public health policy. This hypothesis is currently being tested in a number of prospective intervention trials. The aim of this article is to review the evidence that vitamin D status influences early lung development, with a focus on early life mechanisms. © 2011 Bentham Science Publishers.
Leitao E, Morales F, Warner JO, et al., 2011, Safety of Pollinex Quattro pollen immunotherapy in children, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1860-1860, ISSN: 0954-7894
Minshall E, Stefanaki E, Boyle R, et al., 2011, The relationship between food allergy and clinical reactivity to sesame in a tertiary paediatric allergy care setting, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1864-1865, ISSN: 0954-7894
Lau G, Hodes M, Warner JO, et al., 2011, Anxiety, stress and risk perception in the mothers of food allergic children, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1862-1862, ISSN: 0954-7894
Patel N, Boyle RJ, Warner JO, et al., 2011, Anxiety in children with food allergy, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1861-1862, ISSN: 0954-7894
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- Citations: 1
Menikou S, Warner JO, Botto M, et al., 2011, The role of the complotype in determining the severity of systemic allergic reactions to peanuts, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1860-1861, ISSN: 0954-7894
Ahmad Z, Cainer L, Tam H, et al., 2011, An audit of anaphylaxis management in a paediatric accident and emergency department, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1853-1853, ISSN: 0954-7894
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- Citations: 1
Gore R, Boyle RJ, Hanna H, et al., 2011, Personal allergen exposure is increased by turning over in bed and improved by temperature-controlled laminar airflow, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1848-1848, ISSN: 0954-7894
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- Citations: 3
Vosicka K, di Pasquale J, Gore R, et al., 2011, Effects of Temperature-controlled laminar airflow on sleep quality in allergic rhinitis: a pilot study, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1847-1847, ISSN: 0954-7894
Lau G, Hodes M, Warner JO, et al., 2011, Anxiety, stress and risk perception in the mothers of food allergic children, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1825-1826, ISSN: 0954-7894
Boyle RJ, Pedroletti C, Wickman M, et al., 2011, Nocturnal temperature controlled laminar airflow for treating atopic asthma: a randomised controlled trial, Thorax, Vol: 67, Pages: 215-221, ISSN: 0040-6376
Objective To determine whether environmental control using nocturnal temperature controlled laminar airflow (TLA) treatment could improve the quality of life of patients with persistent atopic asthma.Design Randomised, double-blind, placebo-controlled, parallel-group trial.Setting Nineteen European asthma clinics.Participants 312 patients aged 7–70 with inadequately controlled persistent atopic asthma.Main outcome measure Proportion of patients with an increase of ≥0.5 points in asthma quality of life score after 1 year of treatment.Results TLA devices were successfully installed in the bedrooms of 282 (90%) patients included in the primary efficacy analysis. There was a difference in treatment response rate between active (143 of 189, 76%) and placebo (56 of 92, 61%) groups, difference 14.8% (95% CI 3.1 to 26.5, p=0.02).3 In patients aged ≥12, on whom the study was powered, the difference in response rate was similar-active 106 of 143 (74%), placebo 42 of 70 (60%), difference 14.1% (0.6 to 27.7, p=0.059). There was a difference between groups in fractional exhaled nitric oxide change of −7.1 ppb (−13.6 to −0.7, p=0.03). Active treatment was associated with less increase in cat-specific IgE than placebo. There was no difference in adverse event rates between treatment groups.Conclusion Inhalant exposure reduction with TLA improves quality of life, airway inflammation and systemic allergy in patients with persistent atopic asthma. TLA may be a treatment option for patients with inadequately controlled persistent atopic asthma.
Boyle RJ, Lahtinen SJ, Tang ML, 2011, Nutrition and Skin, Nutrition and Skin, Editors: Pappas, Publisher: Springer Science and Business Media, ISBN: 9781441979667
The book will educate and decode the role of vitamins, essential fatty acids and other nutraceuticals on skin health and their tremendous impact to the current ...
Boyle RJ, 2011, Illustrated Textbook of Paediatrics, Illustrated Textbook of Paediatrics, Editors: Lissauer, Clayden, Publisher: Elsevier,Urban&FischerVerlag, Pages: 277-283, ISBN: 9783437410321
Umasunthar T, Warner J, Boyle R, 2011, Defining the risks associated with food allergy, 30th Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY-BLACKWELL, Pages: 230-230, ISSN: 0105-4538
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