Publications
375 results found
Allen H, Boyle RJ, 2022, Dietary management of breastfed children with food allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 29-32, ISSN: 0954-7894
Boyle RJ, Shamji MH, 2022, Milk allergy over-diagnosis, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 4-6, ISSN: 0954-7894
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- Citations: 1
Smith TDH, Townsend R, Hussain HS, et al., 2022, Milk allergy guidelines for infants in England promote over-diagnosis: A cross-sectional survey, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 188-191, ISSN: 0954-7894
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- Citations: 7
Genuneit J, Jayasinghe S, Riggioni C, et al., 2022, Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 33, ISSN: 0905-6157
Musters AH, Mashayekhi S, Harvey J, et al., 2022, PHOTOTHERAPY FOR ATOPIC ECZEMA: A COCHRANE SYSTEMATIC REVIEW, Publisher: ACTA DERMATO-VENEREOLOGICA, Pages: 40-40, ISSN: 0001-5555
Bradshaw LE, Wyatt LA, Chalmers JR, et al., 2022, EMOLLIENTS FOR ATOPIC DERMATITIS PREVENTION: 5-YEAR RESULTS FROM THE BEEP RANDOMISED TRIAL, Publisher: ACTA DERMATO-VENEREOLOGICA, Pages: 9-9, ISSN: 0001-5555
Van Vogt E, Cro S, Cornelius VR, et al., 2021, Individual participant data meta-analysis versus aggregate data meta-analysis: a case study in eczema and food allergy prevention., Clinical and Experimental Allergy, Vol: 52, ISSN: 0954-7894
INTRODUCTION: Meta-analysis traditionally uses aggregate data from published reports. Individual Participant Data (IPD) meta-analysis, which obtains and synthesises participant-level data, is potentially more informative, but resource-intensive. The impact on the findings of meta-analyses using IPD in comparison to aggregate data has rarely been formally evaluated. METHODS: We conducted a secondary analysis of a Cochrane systematic review of skin care interventions for preventing eczema and food allergy in infants to identify the impact of the analytical choice on the review's findings. We used aggregate data meta-analysis only and contrasted the results against those of the originally published IPD meta-analysis. All meta-analysis used random effects inverse variance models. Certainty of evidence was evaluated using GRADE. RESULTS: The pooled treatment effects for the Cochrane systematic review's co-primary outcomes of eczema and food allergy were similar in IPD meta-analysis (eczema RR 1.03, 95% CI 0.81, 1.31; I2 41%, 7 studies 3075 participants), and aggregate meta-analysis (eczema RR 1.01 95% CI 0.77, 1.33; I2 53%, 7 studies, 3089 participants). In aggregate meta-analysis the statistical heterogeneity could not be explained but using IPD it was explained by one trial which used a different, bathing intervention. For IPD meta-analysis, risk of bias was assessed as lower and more adverse event data were available compared with aggregate meta-analysis. This resulted in higher certainty of evidence, especially for adverse events. IPD meta-analysis enabled analysis of treatment interactions by age and hereditary eczema risk; and analysis of the effect of treatment adherence using pooled complier-adjusted-causal-effect analysis, none of which was possible in aggregate meta-analysis. CONCLUSIONS: For this systematic review, IPD did not significantly change primary outcome risk ratios compared with aggregate data meta-analysis. However, certainty of evidence, safety out
Shamji MH, Boyle RJ, Fox AT, 2021, Prize-winning abstracts from BSACI 2021 meeting, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1529-1530, ISSN: 0954-7894
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- Citations: 2
Boyle RJ, Shamji MH, 2021, Developments in the field of allergy in 2020 through the eyes of Clinical and Experimental Allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1531-1537, ISSN: 0954-7894
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- Citations: 1
Shamji MH, Boyle RJ, 2021, Allergic diseases and novel targets in allergen immunotherapy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1526-1528, ISSN: 0954-7894
Mehta S, Allen HI, Simpson MR, et al., 2021, Patterns of specialised formula consumption in Australia, England and Norway suggest significant milk allergy over-diagnosis, Publisher: WILEY, Pages: 1661-1661, ISSN: 0954-7894
Pendower UM, Allen HI, Boyle RJ, 2021, A Delphi consensus project to guide the safe detection and management of cow's milk allergy in infants and children, Publisher: WILEY, Pages: 1689-1689, ISSN: 0954-7894
Helfer B, Leonardi-Bee J, Mundell A, et al., 2021, Conduct and reporting of formula milk trials: systematic review (vol 375, n2202, 2021), BMJ: British Medical Journal, Vol: 375, Pages: 1-1, ISSN: 0959-535X
Singleton H, Hodder A, Boyers D, et al., 2021, Psychological and educational interventions for managing eczema, Cochrane Database of Systematic Reviews, Vol: 2021, ISSN: 1465-1858
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. 1. To assess the clinical outcomes of psychological and educational interventions in children and adults with eczema. 2. To summarise the availability and principal findings of relevant economic evaluations.
Boyle RJ, Shamji MH, 2021, Making causal inferences in allergy epidemiology studies, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1404-1406, ISSN: 0954-7894
Patel N, Chong KW, Yip AYG, et al., 2021, Use of multiple epinephrine doses in anaphylaxis: A systematic review and meta-analysis, Journal of Allergy and Clinical Immunology, Vol: 148, Pages: 1307-1315, ISSN: 0091-6749
Background:Regulatory bodies recommend that all patients at risk of anaphylaxis be prescribed 2 epinephrine autoinjectors, which they should carry at all times. This is in contrast to some guidelines. The proportion of anaphylaxis reactions that are treated with multiple doses of epinephrine has not been systematically evaluated.Objective:Our aim was to undertake a systematic review and meta-analysis of published studies reporting epinephrine treatment for anaphylaxis in which data relating to the number of doses administered were available.Methods:We searched the Medline, Embase, and Cochrane databases for relevant studies reporting at least 10 anaphylaxis events (due to food or venom) from 1946 until January 2020. Data were extracted in duplicate for the meta-analysis, and the risk of bias was assessed. The study was registered under the PROSPERO identifier CRD42017069109.Results:A total of 86 studies (36,557 anaphylaxis events) met the inclusion criteria (20 of the studies [23%] were prospective studies; 64 [74%] reported reactions in the community, and 22 [26%] included food challenge data). Risk of bias was assessed as low in 50 studies. Overall, 7.7% of anaphylaxis events from any cause (95% CI = 6.4-9.1) were treated with multiple doses of epinephrine. When only epinephrine-treated reactions for which subsequent doses were administered by a health care professional were considered, 11.1% of food-induced reactions (95% CI = 9.4-13.2) and 17.1% of venom-induced reactions (95% CI = 11.3-25.0) were treated with at least 1 epinephrine dose. Heterogeneity was moderate to high in the meta-analyses, but at sensitivity analysis it was not affected by study design or anaphylaxis definition.Conclusion:Around 1 in 10 anaphylaxis reactions are treated with at least 1 dose of epinephrine.
Helfer B, Leonardi-Bee J, Mundell A, et al., 2021, Conduct and reporting of formula milk trials: systematic review, BMJ: British Medical Journal, Vol: 375, Pages: 1-9, ISSN: 0959-535X
Objective To systematically review the conduct and reporting of formula trials.Design Systematic review.Data sources Medline, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from 1 January 2006 to 31 December 2020.Review methods Intervention trials comparing at least two formula products in children less than three years of age were included, but not trials of human breast milk or fortifiers of breast milk. Data were extracted in duplicate and primary outcome data were synthesised for meta-analysis with a random effects model weighted by the inverse variance method. Risk of bias was evaluated with Cochrane risk of bias version 2.0, and risk of undermining breastfeeding was evaluated according to published consensus guidance. Primary outcomes of the trials included in the systematic review were identified from clinical trial registries, protocols, or trial publications.Results 22 201 titles were screened and 307 trials were identified that were published between 2006 and 2020, of which 73 (24%) trials in 13 197 children were prospectively registered. Another 111 unpublished but registered trials in 17 411 children were identified. Detailed analysis was undertaken for 125 trials (23 757 children) published since 2015. Seventeen (14%) of these recently published trials were conducted independently of formula companies, 26 (21%) were prospectively registered with a clear aim and primary outcome, and authors or sponsors shared prospective protocols for 11 (9%) trials. Risk of bias was low in five (4%) and high in 100 (80%) recently published trials, mainly because of inappropriate exclusions from analysis and selective reporting. For 68 recently published superiority trials, a pooled standardised mean difference of 0.51 (range −0.43 to 3.29) was calculated with an asymmetrical funnel plot (Egger’s test P<0.001), which reduced to 0.19 after correction for asymmetry. Primary outcomes were reporte
Shamji MH, Boyle RJ, 2021, Unmet needs in food allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1258-1259, ISSN: 0954-7894
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- Citations: 1
Boyle RJ, Shamji MH, 2021, Allergy societies and the formula industry, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1260-1261, ISSN: 0954-7894
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- Citations: 7
Boyle RJ, Shamji MH, 2021, Asthma management and impact on COVID-19 outcomes, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1100-1102, ISSN: 0954-7894
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- Citations: 1
Allan PJ, Ambrose T, Mountford C, et al., 2021, COVID-19 infection in patients with intestinal failure: UK experience, JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, Vol: 45, Pages: 1369-1375, ISSN: 0148-6071
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- Citations: 4
Shamji MH, Boyle RJ, 2021, Biomarkers in asthma and allergic diseases, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 982-984, ISSN: 0954-7894
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- Citations: 1
Boyle RJ, Shamji MH, 2021, Evidence Synthesis in Allergy - A call for submissions, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 868-869, ISSN: 0954-7894
Halken S, Muraro A, de Silva D, et al., 2021, EAACI guideline: Preventing the development of food allergy in infants and young children (2020 update), PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 32, Pages: 843-858, ISSN: 0905-6157
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- Citations: 142
Shamji MH, Boyle RJ, 2021, Real word evidence studies: Is it the way forward?, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 748-750, ISSN: 0954-7894
Argiz L, Infante S, Machinena A, et al., 2021, Children with acute food protein-induced enterocolitis syndrome from Spain and Italy usually tolerate all other food groups, Clinical and Experimental Allergy, Vol: 51, Pages: 1238-1241, ISSN: 0954-7894
Turner P, Ruiz-Garcia M, Patel N, et al., 2021, Delayed symptoms and orthostatic intolerance following peanut challenge, Clinical and Experimental Allergy, Vol: 51, Pages: 696-702, ISSN: 0954-7894
BackgroundClinical reactions to Oral Food Challenge (OFC) in peanut‐allergic individuals have been well‐characterised, but rates and phenotypes of symptom recurrence beyond the first hour after objective symptoms are less well‐characterised.ObjectiveTo evaluate the rate of new‐onset symptoms occurring at least 1 h after stopping OFC in peanut‐allergic children and adults undergoing peanut‐OFC.MethodsWe prospectively collected data relating to adverse events following positive reactions at double‐blind, placebo‐controlled food challenges (DBPCFC) to peanut in children and adults evaluated for eligibility to participate in two clinical trials (NCT02149719, NCT02665793). The trials included people aged 8 to 45 with primary, IgE‐mediated peanut allergy at DBPCFC. The challenge protocol included consumption of a light meal 1 h after reaction.ResultsA total of 121 participants (64 children, 57 adults) had immediate, objective symptoms at DBPCFC, 25 (17 children, 8 adults) with anaphylaxis. Thirty‐three (27%) had progression or recurrence of symptoms ≥ 1 h after objective clinical reaction, of whom 8 developed anaphylaxis. In 23 cases, the onset of new symptoms was associated with consumption of a light meal. In eight cases, symptoms were limited to a symptomatic postural fall in blood pressure noted in preparation for discharge, without any other new features of an allergic reaction.Conclusions & Clinical RelevanceProgressive or new‐onset symptoms ≥1 h following initial allergic reaction at OFC are common and can include orthostatic hypotension. Recurrent symptoms may be temporally associated with food consumption.
Boyle RJ, Shamji MH, 2021, What does it mean to be food allergic?, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 634-635, ISSN: 0954-7894
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- Citations: 2
Gilbertson A, Boyle RJ, MacNeill S, et al., 2021, Healthcare professionals' beliefs and practices regarding food allergy testing for children with eczema, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 735-739, ISSN: 0954-7894
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- Citations: 1
Genuneit J, Boyle RJ, 2021, Hydrolysed formula and allergy prevention, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 32, Pages: 667-669, ISSN: 0905-6157
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- Citations: 3
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