Publications
375 results found
Tang MLK, Boyle RJ, 2019, Oral Immunotherapy for Peanut Allergy, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 380, Pages: 690-691, ISSN: 0028-4793
Turner PJ, Patel N, Ruiz-Garcia M, et al., 2019, Changes in Whole Blood Transcriptome during Peanut-Induced Anaphylaxis and Correlation with Symptoms, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB423-AB423, ISSN: 0091-6749
Dua S, Garcia MR, Bond S, et al., 2019, Reaction thresholds in in peanut-allergic adults and the influence of exercise and sleep deprivation: a randomised controlled trial, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB202-AB202, ISSN: 0091-6749
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Roberts G, Almqvist C, Boyle R, et al., 2018, Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 48, Pages: 1606-1621, ISSN: 0954-7894
Makrgeorgou A, Leonardi-Bee J, Bath-Hextall FJ, et al., 2018, Probiotics for treating eczema, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X
Dua S, Garcia MR, Bond S, et al., 2018, Reactivity thresholds in peanut allergic adults and the influence of stress and exercise: a randomised controlled trial, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY, Pages: 1524-1524, ISSN: 0954-7894
Munblit D, Abrol P, Sheth S, et al., 2018, Levels of growth factors and IgA in colostrum of women from Burundi and Italy, Nutrients, Vol: 10, ISSN: 2072-6643
Colostrum is produced in the first days postpartum. It is a known source of immune mediators for a newborn within the first week of life. Although it is still unclear if colostrum composition varies between populations, recent data suggest differences. Hepatocyte growth factor (HGF); transforming growth factor-β (TGF-β) 1, 2, and 3; and immunoglobulin A (IgA) are key immunological components of colostrum that stimulate neonatal gastrointestinal and immune system development. We aimed to investigate the differences in the concentration between immune markers in the colostrum of mothers living in Burundi and Italy, and to identify the factors associated with differences. In this cross-sectional birth cohort study, a total of 99 colostrum samples from Burundian (n = 23) and Italian (n = 76) women were collected at 0 to 6 days postpartum. A clinical chemistry analyser was used for IgA quantification and electro-chemiluminescence, for HGF and TGFβ1-3 assessment. A univariate analysis and multivariate linear regression model were used for statistical testing. The concentrations of TGF-β2 (p = 0.01) and IgA (p < 0.01) were significantly higher in the colostrum from the women residing in Burundi than in Italy, both in a univariate analysis and upon the adjustment for confounding factors. A similar trend is seen for HGF, reaching statistical significance upon a multivariate analysis. We found a moderate to strong positive correlation between the TGF-β isoforms and IgA concentration in both countries (p < 0.01), with stronger concentration in the colostrum from Burundi. The results of this study are in support of previous data, suggesting that concentration of the immune active molecules is higher in the human milk of women residing in developing countries. However, with a small sample size, caution must be applied, as the findings require further confirmation. Future work should also be focused on other factors (e.g., lipid and microbial compos
Waidyatillake NT, Dharmage SC, Allen K, et al., 2018, Association between the age of solid food introduction and eczema; a systematic review and a meta-analysis, Clinical and Experimental Allergy, Vol: 48, Pages: 1000-1015, ISSN: 0954-7894
INTRODUCTION: Eczema is a common childhood ailment responsible for a considerable disease burden. Both timing of introduction to solid food and allergenic food are believed to be related to childhood eczema. Despite the growing body of evidence, the relationship between timing of any solid food introduction (allergenic and/or non-allergenic) and development of eczema has not previously been systematically reviewed. METHODS: PubMed and EMBASE databases were searched using food and eczema terms. Two authors selected papers according to the inclusion criteria and extracted information on study characteristics and measures of association. Meta-analyses were performed after grouping studies according to the age and type of exposure. RESULTS: A total of 17 papers met the inclusion criteria, reporting results from 16 study populations. Of these, 11 were cohort studies, two case controls, one cross sectional study and, 2 randomised controlled trials. Limited meta-analyses were performed due to heterogeneity between studies. Timing of solid food introduction was not associated with eczema. One randomized controlled trial provided weak evidence of an association between early allergenic (around 4 months) food introduction and reduced risk of eczema. CONCLUSIONS: The available evidence is currently insufficient to determine whether the timing of introduction of any solid food influences the risk of eczema. This article is protected by copyright. All rights reserved.
Ruiz-Garcia M, Haider S, Tattersall Z, et al., 2018, Assessment of the relationship between skin prick test (SPT) reactivity and phenotype of peanut allergic reaction, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY, Pages: 358-358, ISSN: 0105-4538
Dua S, Bond S, Boyle R, et al., 2018, The effect of sleep deprivation and exercise on peanut allergy thresholds: Insights from the Thresholds of Reactivity and Clinical Evaluation (TRACE) Study, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY, Pages: 55-55, ISSN: 0105-4538
Khaleva E, Gridneva Z, Geddes D, et al., 2018, TGF-beta in human milk and allergic outcomes in children: A systematic review, ALLERGY, Vol: 73, Pages: 682-683, ISSN: 0105-4538
Mavroudi A, Chrysochoou E-A, Boyle RJ, et al., 2018, Validation of the children's sleep habits questionnaire in a sample of Greek children with allergic rhinitis, Allergologia et Immunopathologia, Vol: 46, Pages: 389-393, ISSN: 0301-0546
BACKGROUND: Obstructive respiratory disorders, such as allergic rhinitis and asthma may impair sleep quality. The aim of this study is to validate the Children's Sleep Habits Questionnaire (CSHQ) for Greek children from 6 to 14 years of age. No validated tool has been developed so far to assess sleep disturbances in Greek school-aged children. METHODS: We examined the reliability and validity of the CSHQ in a sample of children with allergic rhinitis (AR) and a non-clinical population of parents of these children as a proxy measure of children's AR quality of life (QoL) as evaluated by the Pediatric Allergic Rhinitis Quality of Life (PedARQoL) questionnaire. RESULTS: The CSHQ questionnaire Child's Form (CF) had a moderate internal consistency with a Cronbach's alpha 0.671 and Guttman split-half coefficient of 0.563 when correlated with the PedARQoL (CF). There was also a moderate intraclass correlation of ICC=0.505 between the responses to both questionnaires in the two visits. The CSHQ Parent's Form (PF) had a very good internal consistency with a Cronbach's alpha of 0.928 and Guttman split-half coefficient of 0.798. There was a high intraclass correlation of 0.643 between the responses in the two visits. CONCLUSIONS: The Greek version of the CSHQ CF, but particularly the PF has proved to be a very reliable clinical instrument, which can be used in clinical trials for assessing sleep quality in school-aged children with sleep disturbances because of obstructive airway disorders, such as AR.
Ridd MJ, Chalmers J, Santer M, et al., 2018, Trial of Eczema Allergy Screening Tests (TEST) study protocol: feasibility randomized controlled trial with economic scoping and nested qualitative study, 10th George Rajka International Symposium on Atopic Dermatitis, Publisher: WILEY, Pages: E56-E56, ISSN: 0007-0963
Biggs K, Hurrell K, Matthews E, et al., 2018, Formula milk supplementation on the postnatal ward: a cross-sectional analytical study, Nutrients, Vol: 10, ISSN: 2072-6643
Breastfeeding rates are low in the UK, where approximately one quarter of infants receive a breastmilk substitute (BMS) in the first week of life. We investigated the reasons for early BMS use in two large maternity units in the UK, in order to understand the reasons for the high rate of early BMS use in this setting. Data were collected through infant feeding records, as well as maternal and midwife surveys in 2016. During 2016, 28% of infants received a BMS supplement prior to discharge from the hospital maternity units with only 10% supplementation being clinically indicated. There was wide variation in BMS initiation rates between different midwives, which was associated with ward environment and midwife educational level. Specific management factors associated with non-clinically indicated initiation of BMS were the absence of skin-to-skin contact within an hour of delivery (p = 0.01), and no attendance at an antenatal breastfeeding discussion (p = 0.01). These findings suggest that risk of initiating a BMS during postnatal hospital stay is largely modifiable. Concordance with UNICEF Baby Friendly 10 steps, attention to specific features of the postnatal ward working environment, and the targeting of midwives and mothers with poor educational status may all lead to improved exclusive breastfeeding rates at hospital discharge.
Turner PJ, Campbell DE, Boyle R, et al., 2018, Primary prevention of food allergy: translating evidence from clinical trials to population-based recommendations, Journal of Allergy and Clinical Immunology: In Practice, Vol: 6, Pages: 367-375, ISSN: 2213-2198
Given the prevalence and impact of childhood food allergy, there is increasing interest in interventions targeting disease prevention. Although interventions such as early introduction of dietary peanut have demonstrated efficacy in a small number of well-conducted randomized clinical trials, evidence for broader effectiveness and successful implementation at a population level is still lacking, although epidemiological data suggest that such strategies are likely to be successful, at least for peanut. In this commentary, we explore the issues of translating evidence of efficacy studies (performed under optimal conditions) to make policy recommendations at a population level, and highlight potential benefits, harms, and unintended consequences of making population-based recommendations on the basis of randomized controlled trials. We discuss the complexity and barriers to effective primary and secondary prevention intervention implementation in resource-poor settings.
Garcia-Larsen V, Ierodiakonou D, Jarrold K, et al., 2018, Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis, PLoS Medicine, Vol: 15, ISSN: 1549-1277
Background:There is uncertainty about the influence of diet during pregnancy and infancy on a child’s immune development. We assessed whether variations in maternal or infant diet can influence risk of allergic or autoimmune disease.Methods and findings:Two authors selected studies, extracted data, and assessed risk of bias. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to assess certainty of findings. We searched Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica dataBASE (EMBASE), Web of Science, Central Register of Controlled Trials (CENTRAL), and Literatura Latino Americana em Ciências da Saúde (LILACS) between January 1946 and July 2013 for observational studies and until December 2017 for intervention studies that evaluated the relationship between diet during pregnancy, lactation, or the first year of life and future risk of allergic or autoimmune disease. We identified 260 original studies (964,143 participants) of milk feeding, including 1 intervention trial of breastfeeding promotion, and 173 original studies (542,672 participants) of other maternal or infant dietary exposures, including 80 trials of maternal (n = 26), infant (n = 32), or combined (n = 22) interventions. Risk of bias was high in 125 (48%) milk feeding studies and 44 (25%) studies of other dietary exposures. Evidence from 19 intervention trials suggests that oral supplementation with nonpathogenic micro-organisms (probiotics) during late pregnancy and lactation may reduce risk of eczema (Risk Ratio [RR] 0.78; 95% CI 0.68–0.90; I2 = 61%; Absolute Risk Reduction 44 cases per 1,000; 95% CI 20–64), and 6 trials suggest that fish oil supplementation during pregnancy and lactation may reduce risk of allergic sensitisation to egg (RR 0.69, 95% CI 0.53–0.90; I2 = 15%; Absolute Risk Reduction 31 cases per 1,000; 95% CI 10–47). GRADE certainty of these findings was moderate. We found weaker
Turner PJ, Garcia MR, Skypala IJ, et al., 2018, CHANGES IN METABONOMIC PROFILE DURING PEANUT-INDUCED ANAPHYLAXIS AND CORRELATION WITH SYMPTOM, American-Academy-of-Allergy-Asthma-and-Immunology / World-Allergy-Organization Joint Congress, Publisher: MOSBY-ELSEVIER, Pages: AB85-AB85, ISSN: 0091-6749
Devani P, Ruparelia A, Garcia-Larsen V, et al., 2017, Optimal mode of delivery for using probiotics or prebiotics to prevent eczema: a systematic review and meta-analysis, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY, Pages: 1700-1700, ISSN: 0954-7894
Ruparelia A, Devani P, Garcia-Larsen V, et al., 2017, Fatty acid supplementation during pregnancy, lactation or infancy and risk of allergic outcomes: A systematic review, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY, Pages: 1720-1720, ISSN: 0954-7894
Roberts G, Boyle R, Crane J, et al., 2017, Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy, Clinical and Experimental Allergy, Vol: 47, Pages: 1512-1525, ISSN: 0954-7894
n this article, we described the development in the field of allergy as described by Clinical and Experimental Allergy in 2016. Experimental models of allergic disease, basic mechanisms, clinical mechanisms, allergens, asthma and rhinitis, and clinical allergy are all covered.
Boyle RJ, Umasunthar T, Smith JG, et al., 2017, A brief psychological intervention for mothers of children with food allergy can change risk perception and reduce anxiety: Outcomes of a randomized controlled trial, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 47, Pages: 1309-1317, ISSN: 0954-7894
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- Citations: 26
Turner PJ, Jerschow E, Umasunthar T, et al., 2017, Fatal anaphylaxis: mortality rate and risk factors, Journal of Allergy and Clinical Immunology: In Practice, Vol: 5, Pages: 1169-1178, ISSN: 2213-2198
Up to 5% of the US population have suffered anaphylaxis. Fatal outcome is rare, such that even for people with known venom or food allergy, fatal anaphylaxis constitutes less than 1% of total mortality risk. The incidence of fatal anaphylaxis has not increased in line with hospital admissions for anaphylaxis. Fatal drug anaphylaxis may be increasing, but rates of fatal anaphylaxis to venom and food are stable. Risk factors for fatal anaphylaxis vary according to cause. For fatal drug anaphylaxis, previous cardiovascular morbidity and older age are risk factors, with beta-lactam antibiotics, general anaesthetic agents and radiocontrast injections the commonest triggers. Fatal food anaphylaxis most commonly occurs during the second and third decades. Delayed epinephrine administration is a risk factor; common triggers are nuts, seafood, and in children milk. For fatal venom anaphylaxis, risk factors include middle-age, male sex, white race, cardiovascular disease and possibly mastocytosis; insect triggers vary by region. Upright posture is a feature of fatal anaphylaxis to both food and venom. The rarity of fatal anaphylaxis, and the significant quality of life impact of allergic conditions, suggest that quality of life impairment should be a key consideration when making treatment decisions in patients at risk for anaphylaxis.
Cepeda AM, Thawer S, Boyle RJ, et al., 2017, Diet and respiratory health in children from 11 Latin American countries: evidence from ISAAC Phase III, Lung, Vol: 195, Pages: 683-692, ISSN: 0341-2040
Background and Aim The burden of childhood asthma andits risk factors is an important but neglected public healthchallenge in Latin America. We investigated the associationbetween allergic symptoms and dietary intake inchildren from this region.Methods As part of the International Study of Asthma andAllergies in Childhood (ISAAC) Phase III, questionnairecollected dietary intake was investigated in relation to riskof parental/child reported current wheeze (primary outcome)and rhino-conjunctivitis and eczema. Per-countryadjusted logistic regressions were performed, and combinedeffect sizes were calculated with meta-analyses.Results 143,967 children from 11 countries had completedata. In children aged 6–7 years, current wheeze wasnegatively associated with higher fruit intake (adjustedodds ratio [aOR] 0.65; 95% CI 0.74, 0.97). Current rhinoconjunctivitisand eczema were statistically negativelyassociated with fruit intake (aOR 0.72; 95% CI 0.64, 0.82;and OR 0.64, 95% CI 0.56, 0.74, respectively).Vegetable intake was negatively associated with risk ofsymptoms in younger children, but these associations wereattenuated in the 13–14 years old group. Fastfood/burgerintake was positively associated with all three outcomes inthe older children.Conclusion A higher intake of fruits and vegetables wasassociated with a lower prevalence of allergic symptoms inLatin American children. Conversely, intake of fastfood was positively associated with a higher prevalence ofwheeze in adolescents. Improved dietary habits in childrenmight help reduce the epidemic of allergic symptoms inLatin America. Food interventions in asthmatic childrenare needed to evaluate the possible public health impact ofa better diet on respiratory health.
Munblit D, Peroni DG, Boix-Amoros A, et al., 2017, Human Milk and Allergic Diseases: An Unsolved Puzzle, NUTRIENTS, Vol: 9, ISSN: 2072-6643
There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known that human milk composition is very complex and contains variable levels of immune active molecules, oligosaccharides, metabolites, vitamins and other nutrients and microbial content. Existing evidence suggests that modulation of human breast milk composition has potential for preventing allergic diseases in early life. In this review, we discuss associations between breastfeeding/human milk composition and allergy development.
Tang M, Rijnierse A, Nauta A, et al., 2017, Influence of early feeding patterns on eczema development in high-risk infants, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY, Pages: 15-15, ISSN: 0105-4538
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Chalmers JR, Haines RH, Mitchell EJ, et al., 2017, Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial, Trials, Vol: 18, ISSN: 1745-6215
Background:Atopic eczema (AE) is a common skin problem that impairs quality of life and is associated with the development of other atopic diseases including asthma, food allergy and allergic rhinitis. AE treatment is a significant cost burden for health care providers. The purpose of the trial is to investigate whether daily application of emollients for the first year of life can prevent AE developing in high-risk infants (first-degree relative with asthma, AE or allergic rhinitis).Methods:This is a protocol for a pragmatic, two-arm, randomised controlled, multicentre trial. Up to 1400 term infants at high risk of developing AE will be recruited through the community, primary and secondary care in England. Participating families will be randomised in a 1:1 ratio to receive general infant skin-care advice, or general skin-care advice plus emollients with advice to apply daily to the infant for the first year of life. Families will not be blinded to treatment allocation. The primary outcome will be a blinded assessment of AE at 24 months of age using the UK Working Party Diagnostic Criteria for Atopic Eczema. Secondary outcomes are other definitions of AE, time to AE onset, severity of AE (EASI and POEM), presence of other allergic diseases including food allergy, asthma and hay fever, allergic sensitisation, quality of life, cost-effectiveness and safety of the emollients. Subgroup analyses are planned for the primary outcome according to filaggrin genotype and the number of first-degree relatives with AE and other atopic diseases. Families will be followed up by online and postal questionnaire at 3, 6, 12 and 18 months with a face-to-face visit at 24 months. Long-term follow-up until 60 months will be via annual questionnaires.Discussion:This trial will demonstrate whether skin-barrier enhancement through daily emollient for the first year of life can prevent AE from developing in high-risk infants. If effective, this simple and cheap intervention has the potentia
Stiefel G, Anagnostou K, Boyle RJ, et al., 2017, BSACI guideline for the diagnosis and management of peanut and tree nut allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 47, Pages: 719-739, ISSN: 0954-7894
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Munblit D, Treneva M, Peroni DG, et al., 2017, Immune components in human milk are associated with early infant immunological health outcomes: a prospective 3 country analysis, Nutrients, Vol: 9, ISSN: 2072-6643
The role of breastfeeding in improving allergy outcomes in early childhood is still unclear. Evidence suggests that immune mediators in human milk (HM) play a critical role in infant immune maturation as well as protection against atopy/allergy development. We investigated relationships between levels of immune mediators in colostrum and mature milk and infant outcomes in the first year of life. In a large prospective study of 398 pregnant/lactating women in the United Kingdom, Russia and Italy, colostrum and mature human milk (HM) samples were analysed for immune active molecules. Statistical analyses used models adjusting for the site of collection, colostrum collection time, parity and maternal atopic status. Preliminary univariate analysis showed detectable interleukin (IL) 2 and IL13 in HM to be associated with less eczema. This finding was further confirmed in multivariate analysis, with detectable HM IL13 showing protective effect OR 0.18 (95% CI 0.04–0.92). In contrast, a higher risk of eczema was associated with higher HM concentrations of transforming growth factor β (TGFβ) 2 OR 1.04 (95% CI 1.01–1.06) per ng/mL. Parental-reported food allergy was reported less often when IL13 was detectable in colostrum OR 0.10 (95% CI 0.01–0.83). HM hepatocyte growth factor (HGF) was protective for common cold incidence at 12 months OR 0.19 (95% CI 0.04–0.92) per ng/mL. Data from this study suggests that differences in the individual immune composition of HM may have an influence on early life infant health outcomes. Increased TGFβ2 levels in HM are associated with a higher incidence of reported eczema, with detectable IL13 in colostrum showing protective effects for food allergy and sensitization. HGF shows some protective effect on common cold incidence at one year of age. Future studies should be focused on maternal genotype, human milk microbiome and diet influence on human milk immune composition and both short- and long-term h
Ierodiakonou D, Garcia-Larsen V, Boyle RJ, 2017, Allergenic food introduction and childhood risk of allergic or autoimmune disease — reply, JAMA: Journal of the American Medical Association, Vol: 317, Pages: 87-87, ISSN: 0098-7484
Ierodiakonou D, Garcia-Larsen V, Boyle RJ, 2017, Allergenic Food Introduction and Childhood Risk of Allergic or Autoimmune Disease Reply, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 317, Pages: 87-87, ISSN: 0098-7484
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