Imperial College London
Alternate

ProfessorRosemaryBoyton

Faculty of Medicine, Department of Infectious Disease

Professor of Immunology and Respiratory Medicine
 
 
 
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Contact

 

r.boyton

 
 
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Location

 

8N22Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gois:2022:10.1016/j.micinf.2021.104927,
author = {Gois, BM and Peixoto, RF and Guerra-Gomes, IC and de, Sousa Palmeira PH and de, Sousa Dias CN and Galvao, Araujo JM and Veras, RC and Medeiros, IA and Assuncao, Araujo de Azevedo FDL and Boyton, RJ and Altmann, DM and Lima, Keesen TS},
doi = {10.1016/j.micinf.2021.104927},
journal = {Microbes and Infection: a journal on infectious agents and host defenses},
pages = {1--4},
title = {Regulatory T cells in acute and chronic human Chikungunya infection},
url = {http://dx.doi.org/10.1016/j.micinf.2021.104927},
volume = {24},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chikungunya virus (CHIKV) infection generates strong immune responses that are associated with the disease pathophysiology. Regulatory T cells (Treg-cluster of differentiation (CD)-4+CD25highforkhead box P3 (FOXP3+)) are essential for the induction and maintenance of peripheral tolerance. Thus, they play key roles in determining the patient prognosis by preventing excessive immune responses via different suppression immune mechanisms. However, the regulatory mechanisms involved in human CHIKV infection are still poorly understood. Here, we characterize for the first time the Treg cell molecule-associated-mechanism during acute and chronic human Chikungunya disease. Here, we assessed the Treg cell population and molecule-associated mechanism in the peripheral blood samples of acute and chronic patients with Chikungunya. Our results indicate that CHIKV infection is associated with reduced frequency of Tregs, along with the impaired expression and production of Treg functional markers, including CD39, CD73, perforin, granzyme, programmed death 1 (PD-1), cytotoxic T lymphocyte antigen (CTLA)-4, and transforming growth factor (TGF)-β. This observation suggests that Treg cells possess the poor regulatory capacity in both acute and chronic phases of the disease. Taken together, these data provide significant evidence that the imbalanced response of Treg cells plays an essential role in establishing the pathogenesis of Chikungunya.
AU  - Gois,BM
AU  - Peixoto,RF
AU  - Guerra-Gomes,IC
AU  - de,Sousa Palmeira PH
AU  - de,Sousa Dias CN
AU  - Galvao,Araujo JM
AU  - Veras,RC
AU  - Medeiros,IA
AU  - Assuncao,Araujo de Azevedo FDL
AU  - Boyton,RJ
AU  - Altmann,DM
AU  - Lima,Keesen TS
DO  - 10.1016/j.micinf.2021.104927
EP  - 4
PY  - 2022///
SN  - 1286-4579
SP  - 1
TI  - Regulatory T cells in acute and chronic human Chikungunya infection
T2  - Microbes and Infection: a journal on infectious agents and host defenses
UR  - http://dx.doi.org/10.1016/j.micinf.2021.104927
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000821426000010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1286457921001490?via%3Dihub
VL  - 24
ER  -
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