Imperial College London

Dr Robin Carhart-Harris

Faculty of MedicineDepartment of Brain Sciences

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 7992r.carhart-harris

 
 
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Assistant

 

Miss Bruna Cunha +44 (0)20 7594 7992

 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lord:2019:10.1016/j.neuroimage.2019.05.060,
author = {Lord, L-D and Expert, P and Atasoy, S and Roseman, L and Rapuano, K and Lambiotte, R and Nutt, DJ and Deco, G and Carhart-Harris, RL and Kringelbach, ML and Cabral, J},
doi = {10.1016/j.neuroimage.2019.05.060},
journal = {NeuroImage},
pages = {127--142},
title = {Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin},
url = {http://dx.doi.org/10.1016/j.neuroimage.2019.05.060},
volume = {199},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns ('functional brain networks'), which potentially underlie different mental processes. The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly modulated by intravenous infusion of psilocybin, a tryptamine psychedelic found in "magic mushrooms". We employed a data-driven approach to characterize recurrent functional connectivity patterns by focusing on the leading eigenvector of BOLD phase coherence at single-TR resolution. Recurrent BOLD phase-locking patterns (PL states) were assessed and statistically compared pre- and post-infusion of psilocybin in terms of their probability of occurrence and transition profiles. Results were validated using a placebo session. Recurrent BOLD PL states revealed high spatial overlap with canonical resting-state networks. Notably, a PL state forming a frontoparietal subsystem was strongly destabilized after psilocybin injection, with a concomitant increase in the probability of occurrence of another PL state characterized by global BOLD phase coherence. These findings provide evidence of network-specific neuromodulation by psilocybin and represent one of the first attempts at bridging molecular pharmacodynamics and whole-brain network dynamics.
AU - Lord,L-D
AU - Expert,P
AU - Atasoy,S
AU - Roseman,L
AU - Rapuano,K
AU - Lambiotte,R
AU - Nutt,DJ
AU - Deco,G
AU - Carhart-Harris,RL
AU - Kringelbach,ML
AU - Cabral,J
DO - 10.1016/j.neuroimage.2019.05.060
EP - 142
PY - 2019///
SN - 1053-8119
SP - 127
TI - Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin
T2 - NeuroImage
UR - http://dx.doi.org/10.1016/j.neuroimage.2019.05.060
UR - https://www.ncbi.nlm.nih.gov/pubmed/31132450
UR - http://hdl.handle.net/10044/1/71495
VL - 199
ER -