Imperial College London

Dr Robin Carhart-Harris

Faculty of MedicineDepartment of Brain Sciences

Research Fellow
 
 
 
//

Contact

 

+44 (0)20 7594 7992r.carhart-harris

 
 
//

Assistant

 

Miss Bruna Cunha +44 (0)20 7594 7992

 
//

Location

 

Burlington DanesHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Lyons:2018:10.1177/0269881117748902,
author = {Lyons, T and Carhart-Harris, RL},
doi = {10.1177/0269881117748902},
journal = {Journal of Psychopharmacology},
pages = {811--819},
title = {Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression},
url = {http://dx.doi.org/10.1177/0269881117748902},
volume = {32},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Rationale:Previous research suggests that classical psychedelic compounds can induce lasting changes in personality traits, attitudes and beliefs in both healthy subjects and patient populations.Aim:Here we sought to investigate the effects of psilocybin on nature relatedness and libertarian–authoritarian political perspective in patients with treatment-resistant depression (TRD).Methods:This open-label pilot study with a mixed-model design studied the effects of psilocybin on measures of nature relatedness and libertarian–authoritarian political perspective in patients with moderate to severe TRD (n=7) versus age-matched non-treated healthy control subjects (n=7). Psilocybin was administered in two oral dosing sessions (10 mg and 25 mg) 1 week apart. Main outcome measures were collected 1 week and 7–12 months after the second dosing session. Nature relatedness and libertarian–authoritarian political perspective were assessed using the Nature Relatedness Scale (NR-6) and Political Perspective Questionnaire (PPQ-5), respectively.Results:Nature relatedness significantly increased (t(6)=−4.242, p=0.003) and authoritarianism significantly decreased (t(6)=2.120, p=0.039) for the patients 1 week after the dosing sessions. At 7–12 months post-dosing, nature relatedness remained significantly increased (t(5)=−2.707, p=0.021) and authoritarianism remained decreased at trend level (t(5)=−1.811, p=0.065). No differences were found on either measure for the non-treated healthy control subjects.Conclusions:This pilot study suggests that psilocybin with psychological support might produce lasting changes in attitudes and beliefs. Although it would be premature to infer causality from this small study, the possibility of drug-induced changes in belief systems seems sufficiently intriguing and timely to deserve further investigation.
AU - Lyons,T
AU - Carhart-Harris,RL
DO - 10.1177/0269881117748902
EP - 819
PY - 2018///
SN - 1461-7285
SP - 811
TI - Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression
T2 - Journal of Psychopharmacology
UR - http://dx.doi.org/10.1177/0269881117748902
UR - http://hdl.handle.net/10044/1/57965
VL - 32
ER -