Imperial College London
Alternate

Professor Robin Carhart-Harris

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 7594 7992r.carhart-harris

 
 
//

Assistant

 

Miss Bruna Cunha +44 (0)20 7594 7992

 
//

Location

 

Burlington DanesHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Deco:2018:10.1016/j.cub.2018.07.083,
author = {Deco, G and Cruzat, J and Cabral, J and Knudsen, GM and Carhart-Harris, RL and Whybrow, PC and Logothetis, NK and Kringelbach, ML},
doi = {10.1016/j.cub.2018.07.083},
journal = {Current Biology},
pages = {3065--3074.E6},
title = {Whole-brain multimodal neuroimaging model using serotonin receptor maps explains non-linear functional effects of LSD},
url = {http://dx.doi.org/10.1016/j.cub.2018.07.083},
volume = {28},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Understanding the underlying mechanisms of the human brain in health and disease will require models with necessary and sufficient details to explain how function emerges from the underlying anatomy and is shaped by neuromodulation. Here, we provide such a detailed causal explanation using a whole-brain model integrating multimodal imaging in healthy human participants undergoing manipulation of the serotonin system. Specifically, we combined anatomical data from diffusion magnetic resonance imaging (dMRI) and functional magnetic resonance imaging (fMRI) with neurotransmitter data obtained with positron emission tomography (PET) of the detailed serotonin 2A receptor (5-HT2AR) density map. This allowed us to model the resting state (with and without concurrent music listening) and mechanistically explain the functional effects of 5-HT2AR stimulation with lysergic acid diethylamide (LSD) on healthy participants. The whole-brain model used a dynamical mean-field quantitative description of populations of excitatory and inhibitory neurons as well as the associated synaptic dynamics, where the neuronal gain function of the model is modulated by the 5-HT2AR density. The model identified the causative mechanisms for the non-linear interactions between the neuronal and neurotransmitter system, which are uniquely linked to (1) the underlying anatomical connectivity, (2) the modulation by the specific brainwide distribution of neurotransmitter receptor density, and (3) the non-linear interactions between the two. Taking neuromodulatory activity into account when modeling global brain dynamics will lead to novel insights into human brain function in health and disease and opens exciting possibilities for drug discovery and design in neuropsychiatric disorders.
AU  - Deco,G
AU  - Cruzat,J
AU  - Cabral,J
AU  - Knudsen,GM
AU  - Carhart-Harris,RL
AU  - Whybrow,PC
AU  - Logothetis,NK
AU  - Kringelbach,ML
DO  - 10.1016/j.cub.2018.07.083
EP  - 3074
PY  - 2018///
SN  - 0960-9822
SP  - 3065
TI  - Whole-brain multimodal neuroimaging model using serotonin receptor maps explains non-linear functional effects of LSD
T2  - Current Biology
UR  - http://dx.doi.org/10.1016/j.cub.2018.07.083
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446693400022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 28
ER  -
Download