Imperial College London
Alternate

Professor Robin Carhart-Harris

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 7992r.carhart-harris

 
 
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Assistant

 

Miss Bruna Cunha +44 (0)20 7594 7992

 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Zeifman:2022:osf.io/w8j6t,
author = {Zeifman, R and Spriggs, M and Kettner, H and Lyons, T and Rosas, F and Mediano, P and Erritzoe, D and Carhart-Harris, R},
doi = {osf.io/w8j6t},
publisher = {PsyArXiv},
title = {From Relaxed Beliefs Under Psychedelics (REBUS) to Revised Beliefs After Psychedelics (REBAS): preliminary development of the RElaxed Beliefs Questionnaire (REB-Q)},
url = {http://dx.doi.org/10.31234/osf.io/w8j6t},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Background: The Relaxed Beliefs Under pSychedelics (REBUS) model proposes that serotonergic psychedelics decrease the precision weighting of neurobiologically-encoded beliefs, and offers a unified account of the acute and therapeutic action of psychedelics. Although REBUS has received some neuroscientific support, little research has examined its psychological validity. We conducted a preliminary examination of two psychological assumptions of REBUS: (a) psychedelics foster acute relaxation and post-acute revision of confidence in mental-health-relevant beliefs; (b) this relaxation and revision facilitates positive therapeutic outcomes and is associated with the entropy of EEG signals (an index of neurophysiological mechanisms relevant to REBUS). Method: Healthy individuals (N=11) were administered 1 mg and 25 mg psilocybin 4-weeks apart. Confidence ratings for personally held negative and positive beliefs were obtained before, during, and 4-weeks after dosing sessions. Acute entropy and self-reported subjective experiences were measured, as was well-being (before and 4-weeks after dosing sessions). Results: Confidence in negative self-beliefs decreased following 25 mg psilocybin and not following 1 mg psilocybin. Entropy and subjective effects under 25 mg psilocybin correlated with decreases in negative self-belief confidence (acute and 4-weeks after dosing). Particularly strong evidence was seen for a relationship between decreases in negative self-belief confidence and increases in well-being at 4-weeks. Conclusions: We report the first empirical evidence that the relaxation and revision of negative self-belief confidence mediates positive psychological outcomes; a psychological assumption of REBUS. Replication within larger and clinical samples remains necessary. We also introduce a new measure, the Relaxed BEliefs Questionnaire (REB-Q), for examining the robustness of these preliminary findings and the utility of the REBUS model.
AU  - Zeifman,R
AU  - Spriggs,M
AU  - Kettner,H
AU  - Lyons,T
AU  - Rosas,F
AU  - Mediano,P
AU  - Erritzoe,D
AU  - Carhart-Harris,R
DO  - osf.io/w8j6t
PB  - PsyArXiv
PY  - 2022///
TI  - From Relaxed Beliefs Under Psychedelics (REBUS) to Revised Beliefs After Psychedelics (REBAS): preliminary development of the RElaxed Beliefs Questionnaire (REB-Q)
UR  - http://dx.doi.org/10.31234/osf.io/w8j6t
UR  - https://psyarxiv.com/w8j6t/
UR  - http://hdl.handle.net/10044/1/100179
ER  -
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