Imperial College London
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DrRashedaChowdhury

Faculty of Medicine, National Heart & Lung Institute

Advanced Research Fellow
 
 
 
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r.chowdhury

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ng:2016:10.1016/j.jacep.2016.03.007,
author = {Ng, FS and Kalindjian, JM and Cooper, SA and Chowdhury, RA and Patel, PM and Dupont, E and Lyon, AR and Peters, NS},
doi = {10.1016/j.jacep.2016.03.007},
journal = {JACC. Clinical electrophysiology},
pages = {574--582},
title = {Enhancement of Gap Junction Function During Acute Myocardial Infarction Modifies Healing and Reduces Late Ventricular Arrhythmia Susceptibility},
url = {http://dx.doi.org/10.1016/j.jacep.2016.03.007},
volume = {2},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives: To investigate the effects of enhancing gap junction (GJ) coupling during acute myocardial infarction (MI) on the healed infarct scar morphology and late post-MI arrhythmia susceptibility.Background: Increased heterogeneity of myocardial scarring after MI is associated with greater arrhythmia susceptibility. We hypothesized that short-term enhancement of GJ coupling during acute MI can produce more homogeneous infarct scars, reducing late susceptibility to post-MI arrhythmias. Methods: Following arrhythmic characterisation of the rat 4-week post-MI model (n=24), a further 27 Sprague-Dawley rats were randomised to receive rotigaptide to enhance GJ coupling (n=13) or saline control (n=14) by osmotic minipump immediately prior to, and for the first 7 days following surgical MI. At 4 weeks post-MI, hearts were explanted for ex vivo programmed electrical stimulation (PES) and optical mapping. Heterogeneity of infarct border zone (IBZ) scarring was quantified by histomorphometry. Results: Despite no detectable difference in infarct size at 4 weeks post-MI, rotigaptide-treated hearts had reduced arrhythmia susceptibility during PES (Inducibility score: rotigaptide 2.40.8, control 5.00.6, p=0.02) and less heterogeneous IBZ scarring (standard deviation of IBZ Complexity Score: rotigaptide 1.10.1, control 1.40.1, p=0.04), associated with an improvement in IBZ conduction velocity (rotigaptide 43.13.4 cm/s, control 34.82.0 cm/s, p=0.04). Conclusions:  Enhancement of GJ coupling for only 7 days at the time of acute MI produced more homogeneous IBZ scarring and reduced arrhythmia susceptibility at 4 weeks post-MI. Short-term GJ modulation at the time of MI may represent a novel treatment strategy to modify the healed infarct scar morphology and reduce late post-MI arrhythmic risk.
AU  - Ng,FS
AU  - Kalindjian,JM
AU  - Cooper,SA
AU  - Chowdhury,RA
AU  - Patel,PM
AU  - Dupont,E
AU  - Lyon,AR
AU  - Peters,NS
DO  - 10.1016/j.jacep.2016.03.007
EP  - 582
PY  - 2016///
SN  - 2405-5018
SP  - 574
TI  - Enhancement of Gap Junction Function During Acute Myocardial Infarction Modifies Healing and Reduces Late Ventricular Arrhythmia Susceptibility
T2  - JACC. Clinical electrophysiology
UR  - http://dx.doi.org/10.1016/j.jacep.2016.03.007
UR  - http://hdl.handle.net/10044/1/30422
VL  - 2
ER  -
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