Summary
Dr Ranil de Silva is a Senior Lecturer in Clinical Cardiology and Consultant Interventional Cardiologist at the Royal Brompton Hospital, where he leads the Specialist Angina Service.
Education
Dr de Silva studied Medicine at King’s College School of Medicine and Dentistry. He was awarded a First Class honours degree in Physiology after which he won a Medical Research Council PhD Studentship to continue research under the supervision of Professor Attilio Maseri, Professor Giovanni Mann and Professor Terry Jones at the MRC Cyclotron Unit, Hammersmith Hospital, in the field of cardiac positron emission tomography. He was awarded his PhD in 1993. He then returned to complete his undergraduate medical training and graduated with distinction in 1995.
Dr de Silva completed his training in general and interventional cardiology in London, including at the Royal Brompton, Hammersmith and St Mary’s Hospitals. He undertook post-doctoral research at the Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, USA with Robert Lederman in the area of MRI guided endovascular intervention and biologic therapies for cardiovascular disease.
He was appointed to his current post in August 2007.
Research
Dr de Silva’s research focuses on the use of imaging (invasive intracoronary and non-invasive cross-sectional) in the diagnosis and risk stratification and evaluation of treatment of coronary artery disease. He also has an interest in hypertension management.
His work is funded by the British Heart Foundation. He currently co-supervises 2 PhD and 1 Masters student.
Clinical Trials/Registries
Dr de Silva is UK or site PI for a number of multicentre clinical trials including BLADE (ClinicalTrials.gov identifier NCT02645799); EuroCTO (ClinicalTrials.gov identifier NCT01760083); Lipid Rich Plaque (ClinicalTrials.gov identifier NCT02033694); REDUCER-1 Registry; Ivabradine Drug Utilisation Study in Select European Countries: A Multinational, Retrospective, Observational Study to Assess Effectiveness of Risk-Minimisation Measures.
Current active areas of translational and clinical research
- Shear stress and atherogenesis
- Biomechanical models for the prediction of advanced coronary atherosclerotic plaque development and rupture risk.
- Diffusion tensor cardiac magnetic resonance for prediction of adverse left ventricular remodelling, heart failure and arrhythmic risk after myocardial infarction
- Diagnosis and treatment of microvascular dysfunction.
- Novel approaches to management of patients with refractory angina
- New approaches to the treatment of hypertension (renal denervation, ROX)
Professional Positions
Associate Board Member, NIHR-MRC Efficacy and Mechanism Evaluation Board (2007-2011)
Clinical Lead, Specialist Angina Service, Royal Brompton Hospital (2013-present)
Academic Lead, Coronary Disease Theme, Cardiovascular Research Unit, Royal Brompton Hospital (2016-present)
Member, British Cardiovascular Society Atherothrombosis Clinical Study Group (2016 – present)
Prizes and Awards
Medical Research Council PhD Studentship (1989-1992)
Winner - Japanese College of Cardiology, Young Investigator Competition (1993)
National Institute of Health, Bench to Bedside Award (2005-2008)
Medical Futures Cardiovascular Innovation Award (2008), co-recipient
Orloff Award, NHLBI Division of Intramural Research (2017), co-recipient
Teaching
Dr de Silva is involved in teaching of undergraduate medical students at Imperial.
He is involved in postgraduate teaching trainees in the London Deanery and is Educational Supervisor for trainees at the Royal Brompton Hospital.
He is the Module Lead for Coronary Disease in the MSc/PGCert in Innovations in Cardiovascular Science at NHLI.
Selected Publications
Journal Articles
Tomaniak M, Katagiri Y, Modolo R, et al., 2020, Vulnerable plaques and patients: state-of-the-art, European Heart Journal, Vol:41, ISSN:0195-668X, Pages:2997-3004
Nielles-Vallespin S, Khalique Z, Ferreira PF, et al., 2017, Assessment of myocardial microstructural dynamics by in vivo diffusion tensor cardiac magnetic resonance, Journal of the American College of Cardiology, Vol:69, ISSN:0735-1097, Pages:661-676
Pedrigi RM, Poulsen CB, Mehta VV, et al., 2015, Inducing persistent flow disturbances accelerates atherogenesis and promotes thin cap fibroatheroma development in D374Y-PCSK9 hypercholesterolemic minipigs, Circulation, Vol:132, ISSN:0009-7322, Pages:1003-1012
de Silva R, Tsujioka H, Gaze D, et al., 2015, Serial Changes in High-Sensitivity Cardiac Troponin, N-terminal Pro-B-Type Natriuretic Peptide, and Heart Fatty Acid Binding Protein during Exercise Echocardiography in Patients with Suspected Angina Pectoris and Normal Resting Left Ventricular Function, Clinical Chemistry, Vol:61, ISSN:0009-9147, Pages:554-556
Verheye S, Jolicœur EM, Behan MW, et al., 2015, Efficacy of a device to narrow the coronary sinus in refractory Angina, New England Journal of Medicine, Vol:372, ISSN:0028-4793, Pages:519-527
Verheye S, Jolicoeur EM, Behan MW, et al., 2015, Efficacy of a device to narrow the coronary sinus in refractory angina, New England Journal of Medicine, Vol:372, ISSN:0028-4793, Pages:519-527
Li X, Johnson KR, Bryant M, et al., 2011, Intranasal Delivery of E-Selectin Reduces Atherosclerosis in ApoE-/- Mice, PLOS One, Vol:6, ISSN:1932-6203
Jordan AN, Lyne J, De Silva R, et al., 2010, Myocarditic Appearance of Arrhythmogenic Right Ventricular Cardiomyopathy, Circulation, Vol:122, ISSN:0009-7322, Pages:E556-E557
de Silva R, Fox KM, 2010, PHARMACOTHERAPY Xanthine oxidase inhibition for relief of angina pectoris, Nature Reviews Cardiology, Vol:7, ISSN:1759-5002, Pages:603-604
de Silva R, Fox KM, 2009, The changing horizon of acute coronary syndrome, The Lancet, Vol:374, ISSN:0140-6736, Pages:1125-1127
de Silva R, Raval AN, Hadi M, et al., 2008, Intracoronary infusion of autologous mononuclear cells from bone marrow or granulocyte colony-stimulating factor-mobilized apheresis product <i>may</i> not improve remodelling, contractile function, perfusion, or infarct size in a swine model of large myocardial infarction, European Heart Journal, Vol:29, ISSN:0195-668X, Pages:1772-1782
Gutierrez LF, de Silva R, Ozturk C, et al., 2007, Technology Preview: X-Ray Fused With Magnetic Resonance During Invasive Cardiovascular Procedures, Catheterization and Cardiovascular Interventions, Vol:70, Pages:773-782