Imperial College London
Portrait Picture

Dr Ranil De Silva

Faculty of Medicine, National Heart & Lung Institute

Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7351 8626r.desilva Website

 
 
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Assistant

 

Ms Deborah Curcher +44 (0)20 7351 8626

 
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Location

 

Chelsea WingSydney StreetRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

155 results found

Tung K-P, Shi W-Z, De Silva R, Edwards E, Rueckert Det al., 2011, AUTOMATICAL VESSEL WALL DETECTION IN INTRAVASCULAR CORONARY OCT, 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro, Publisher: IEEE, Pages: 610-613, ISSN: 1945-7928

Conference paper

Jordan AN, Lyne J, De Silva R, Wong Tet al., 2010, Myocarditic Appearance of Arrhythmogenic Right Ventricular Cardiomyopathy, CIRCULATION, Vol: 122, Pages: E556-E557, ISSN: 0009-7322

Journal article

de Silva R, Fox KM, 2010, PHARMACOTHERAPY Xanthine oxidase inhibition for relief of angina pectoris, NATURE REVIEWS CARDIOLOGY, Vol: 7, Pages: 603-604, ISSN: 1759-5002

Journal article

Tyczynski P, Ferrante G, Moreno-Ambroj C, Kukreja N, Barlis P, Pieri E, De Silva R, Beatt K, Di Mario Cet al., 2010, Simple Versus Complex Approaches to Treating Coronary Bifurcation Lesions: Direct Assessment of Stent Strut Apposition by Optical Coherence Tomography, REVISTA ESPANOLA DE CARDIOLOGIA, Vol: 63, Pages: 904-914, ISSN: 1885-5857

Journal article

Tyczynski P, Ferrante G, Moreno-Ambroj C, Kukreja N, Barlis P, Pieri E, de Silva R, Beatt K, di Mario Cet al., 2010, Estrategia simple o compleja para lesiones de bifurcaciones coronarias: evaluación inmediata de la aposición de los struts del stent mediante tomografía de coherencia óptica, Revista Española de Cardiología, Vol: 63, Pages: 904-914, ISSN: 0300-8932

Journal article

Kapur K, Johnson T, Beckmann ND, Sehmi J, Tanaka T, Kutalik Z, Styrkarsdottir U, Zhang W, Marek D, Gudbjartsson DF, Milaneschi Y, Holm H, DiIorio A, Waterworth D, Li Y, Singleton AB, Bjornsdottir US, Sigurdsson G, Hernandez DG, DeSilva R, Elliott P, Eyjolfsson GI, Guralnik JM, Scott J, Thorsteinsdottir U, Bandinelli S, Chambers J, Stefansson K, Waeber G, Ferrucci L, Kooner JS, Mooser V, Vollenweider P, Beckmann JS, Bochud M, Bergmann Set al., 2010, Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR) Gene, PLOS Genetics, Vol: 6, ISSN: 1553-7390

Calcium has a pivotal role in biological functions, and serum calcium levels have been associated with numerous disordersof bone and mineral metabolism, as well as with cardiovascular mortality. Here we report results from a genome-wideassociation study of serum calcium, integrating data from four independent cohorts including a total of 12,865 individualsof European and Indian Asian descent. Our meta-analysis shows that serum calcium is associated with SNPs in or near thecalcium-sensing receptor (CASR) gene on 3q13. The top hit with a p-value of 6.3610-37 is rs1801725, a missense variant,explaining 1.26% of the variance in serum calcium. This SNP had the strongest association in individuals of Europeandescent, while for individuals of Indian Asian descent the top hit was rs17251221 (p = 1.1610-21), a SNP in strong linkagedisequilibrium with rs1801725. The strongest locus in CASR was shown to replicate in an independent Icelandic cohort of4,126 individuals (p = 1.02610-4). This genome-wide meta-analysis shows that common CASR variants modulate serumcalcium levels in the adult general population, which confirms previous results in some candidate gene studies of the CASRlocus. This study highlights the key role of CASR in calcium regulation.

Journal article

Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJL, Beckmann J, Bilo HJG, Bochud M, Brown MJ, Caulfield MJ, Connell JMC, Cook HT, Cotlarciuc I, Smith GD, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic N, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Ferrucci L, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, van der Heide JJH, Hepkema BG, Hernandez-Fuentes M, Hypponen E, Johnson T, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJF, Luan J, Luttropp K, Marechal C, Melander O, Munroe PB, Nordfors L, Parsa A, Peltonen L, Penninx BW, Perucha E, Pouta A, Prokopenko I, Roderick PJ, Ruokonen A, Samani NJ, Sanna S, Schalling M, Schlessinger D, Schlieper G, Seelen MAJ, Shuldiner AR, Sjogren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJE, Swaminathan R, Tanaka T, Ubink-Veltmaat LJ, Uda M, Vollenweider P, Wallace C, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin M-R, Mooser V, Abecasis GR, Lightstone L, Scott J, Navis G, Elliott P, Kooner JSet al., 2010, Genetic loci influencing kidney function and chronic kidney disease, NATURE GENETICS, Vol: 42, Pages: 373-375, ISSN: 1061-4036

Journal article

De Silva R, 2010, Is dual antiplatelet therapy needed for all CVD patients?, British Journal of Cardiology, Vol: 17, ISSN: 0969-6113

Journal article

Chambers JC, Zhao J, Terracciano CMN, Bezzina CR, Zhang W, Kaba R, Navaratnarajah M, Lotlikar A, Sehmi JS, Kooner MK, Deng G, Siedlecka U, Parasramka S, El-Hamamsy I, Wass MN, Dekker LRC, de Jong JSSG, Sternberg MJE, McKenna W, Severs NJ, de Silva R, Wilde AAM, Anand P, Yacoub M, Scott J, Elliott P, Wood JN, Kooner JSet al., 2010, Genetic variation in <i>SCN10A</i> influences cardiac conduction, NATURE GENETICS, Vol: 42, Pages: 149-U80, ISSN: 1061-4036

Journal article

Chambers J, Zhao J, Terracciano C, Bezzina C, Zhang W, Kaba R, Navaratnarajah M, Lotlikar A, Sehmi J, Kooner M, Siedlecka U, Wass M, Dekker L, de Jong J, Sternberg M, McKenna W, Severs N, DeSilva R, Wilde A, Anand P, Yacoub M, Scott J, Elliot P, Wood J, Kooner Jet al., 2009, Genetic Variation in SCN10a is Associated With Cardiac Conduction, Heart Block and Risk of Ventricular Fibrillation, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S579-S580, ISSN: 0009-7322

Conference paper

Tyczynski P, Ferrante G, Kukreja N, Moreno-Ambroj C, Barlis P, Ramasami N, De Silva R, Beatt K, Di Mario Cet al., 2009, Optical coherence tomography assessment of a new dedicated bifurcation stent, EUROINTERVENTION, Vol: 5, Pages: 544-551, ISSN: 1774-024X

Journal article

de Silva R, Fox KM, 2009, The changing horizon of acute coronary syndrome, LANCET, Vol: 374, Pages: 1125-1127, ISSN: 0140-6736

Journal article

Tyczynski P, Ferrante G, Moreno-Ambroj C, Kukreja N, Barlis P, Pieri E, de Silva R, Di Mario Cet al., 2009, Stent Strut Apposition In Coronary Bifurcation Lesions Assessed With Optical Coherence Tomography: One Stent Vs Two Stent (Culotte) Strategy, 21st Annual Transcatheter Cardiovascular Therapeutics Conference, Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 41D-41D, ISSN: 0002-9149

Conference paper

de Silva R, Fox KM, 2009, ANGINA Ivabradine for treatment of stable angina pectoris, NATURE REVIEWS CARDIOLOGY, Vol: 6, Pages: 329-330, ISSN: 1759-5002

Journal article

Mansoor A, Jain P, Mayor A, Singh D, Sehmi J, Chambers JC, De Silva R, Kooner JS, Sethi ASet al., 2008, Indian asians with acute coronary syndromes present almost 10 years earlier and have more extensive angiographic coronary artery disease than European whites, EUROPEAN HEART JOURNAL, Vol: 29, Pages: 659-659, ISSN: 0195-668X

Journal article

de Silva R, Raval AN, Hadi M, Gildea KM, Bonifacino AC, Yu Z-X, Yau YY, Leitman SF, Bacharach SL, Donahue RE, Read EJ, Lederman RJet al., 2008, Intracoronary infusion of autologous mononuclear cells from bone marrow or granulocyte colony-stimulating factor-mobilized apheresis product <i>may</i> not improve remodelling, contractile function, perfusion, or infarct size in a swine model of large myocardial infarction, EUROPEAN HEART JOURNAL, Vol: 29, Pages: 1772-1782, ISSN: 0195-668X

Journal article

de Silva R, Fox K, 2008, Early intervention in acute coronary syndrome: is bivalirudin monotherapy an effective antithrombotic strategy?, NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, Vol: 5, Pages: 308-309, ISSN: 1743-4297

Journal article

Guttman MA, Ozturk C, Raval AN, Raman VK, Dick AJ, DeSilva R, Karmarkar P, Lederman RJ, McVeigh ERet al., 2007, Interventional cardiovascular procedures guided by real-time MR imaging: An interactive interface using multiple slices, adaptive projection modes and live 3D renderings, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 26, Pages: 1429-1435, ISSN: 1053-1807

Journal article

Gutierrez LF, de Silva R, Ozturk C, Sonmez M, Stine AM, Raman VK, Sachdev V, Aviles RJ, Waclawiw MA, McVeigh ER, Lederman RJet al., 2007, Technology Preview: X-Ray Fused With Magnetic Resonance During Invasive Cardiovascular Procedures, Catheterization and Cardiovascular Interventions, Vol: 70, Pages: 773-782

Journal article

de Silva R, Gutierrez LF, Raval AN, McVeigh ER, Ozturk C, Lederman RJet al., 2006, X-ray fused with magnetic resonance imaging (XFM) to target endomyocardial injections - Validation in a swine model of myocardial infarction, CIRCULATION, Vol: 114, Pages: 2342-2350, ISSN: 0009-7322

Journal article

Vignaud A, Rodriguez I, Ennis DB, DeSilva R, Kellman P, Taylor J, Bennett E, Wen Het al., 2006, Detection of myocardial capillary orientation with intravascular iron-oxide nanoparticles in spin-echo MRI, MAGNETIC RESONANCE IN MEDICINE, Vol: 55, Pages: 725-730, ISSN: 0740-3194

Journal article

Raval AN, Karmarkar PV, Guttman MA, Ozturk C, DeSilva R, Aviles RJ, Wright VJ, Schenke WH, Atalar E, McVeigh ER, Lederman RJet al., 2006, Real-time MRI guided atrial septal puncture and balloon septostomy in swine, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 67, Pages: 637-643, ISSN: 1522-1946

Journal article

Raval AN, Karmarkar PV, Guttman MA, Ozturk C, Sampath S, DeSilva R, Aviles RJ, Xu MN, Wright VJ, Schenke WH, Kocaturk O, Dick AJ, Raman VK, Atalar E, McVeigh ER, Lederman RJet al., 2006, Real-time magnetic resonance imaging-guided endovascular recanalization of chronic total arterial occlusion in a swine model, CIRCULATION, Vol: 113, Pages: 1101-1107, ISSN: 0009-7322

Journal article

Gutierrez LF, de Silva R, McVeigh ER, Ozturk C, Lederman RJet al., 2006, Targeted endomyocardial injections of therapeutic cells using X-ray fused with MRI guidance, Medical Imaging 2006 Conference, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

Conference paper

Aviles RJ, Thompson RB, Ozturk C, Raval AN, DeSilva R, Stine A, Wright V, Raman VK, Balaban RS, Lederman RJet al., 2005, Heterogeneous skeletal muscle perfusion recovery after stenting: Insight into regional ischemic blood flow control, 78th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: U417-U418, ISSN: 0009-7322

Conference paper

Mickelsen SR, Ashikaga H, Desilva R, Raval AN, McVeigh E, Kusumoto Fet al., 2005, Transvenous access to the pericardial space: An approach to epicardial lead implantation for cardiac resynchronization therapy, PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol: 28, Pages: 1018-1024, ISSN: 0147-8389

Journal article

Raval AN, Telep JD, Guttman MA, Ozturk C, Jones M, Thompson RB, Wright VJ, Schenke WH, DeSilva R, Aviles RJ, Raman VK, Slack MC, Lederman RJet al., 2005, Real-time magnetic resonance imaging-guided stenting of aortic coarctation with commercially available catheter devices in swine, CIRCULATION, Vol: 112, Pages: 699-706, ISSN: 0009-7322

Journal article

Raman VK, Karmarkar PV, Guttman MA, Dick AJ, Peters DC, Ozturk C, Pessanha BSS, Thompson RB, Raval AN, DeSilva R, Aviles RJ, Atalar E, McVeigh ER, Lederman RJet al., 2005, Real-time magnetic endovascular repair resonance-guided of experimental abdominal aortic aneurysm in swine, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 45, Pages: 2069-2077, ISSN: 0735-1097

Journal article

Raval AN, Karmarkar PV, Guttman MA, Ozturk C, DeSilva R, Aviles RJ, McVeigh ER, Atalar E, Lederman RJet al., 2005, Interactive real-time magnetic resonance-guided atrial septal puncture and atrial balloon septostomy are feasible in swine, 54th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: 328A-329A, ISSN: 0735-1097

Conference paper

Telep JD, Raval AN, Guttman MA, Ozturk C, Jones M, Thompson RB, Wright VJ, Schenke WH, DeSilva R, Aviles RJ, Raman VK, Slack MC, Lederman RJet al., 2005, Real-time MRI guided aortic coarctation stent repair is safe and feasible in a swine model, 54th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: 12A-12A, ISSN: 0735-1097

Conference paper

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