Publications
155 results found
Le Meunier L, Hadi M, de Silva R, et al., 2005, Comparison of three methods of partial volume correction in dynamic PET cardiac imaging - A phantom and a pig study, Nuclear Science Symposium/Medical Imaging Conference, Publisher: IEEE, Pages: 2359-2363, ISSN: 1095-7863
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- Citations: 1
de Silva R, Lederman RJ, 2004, Delivery and tracking of therapeutic cell preparations for clinical cardiovascular applications, Meeting no Clinical Applications of Stem Cells, Pages: 608-614
Experimental observations suggesting adult stem cell plasticity and cross-lineage transdifferentiation have underpinned the investigation of cell therapy for cardiovascular disease. Many challenges still face the full realization of cardiovascular regenerative medicine. This brief review will highlight some of these, with emphasis on the choice of cell preparation, route of cell delivery and tracking of delivered cells.
de Silva R, Lederman RJ, 2004, Delivery and tracking of therapeutic cell preparations for clinical cardiovascular applications, CYTOTHERAPY, Vol: 6, Pages: 608-614, ISSN: 1465-3249
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- Citations: 4
Raval AN, Karmarkar PV, Guttman MA, et al., 2004, Interactive real-time magnetic resonance-guided atrial septal puncture and atrial balloon septostomy are feasible in swine, 77th Scientific Meeting of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 691-691, ISSN: 0009-7322
Raman VK, Karmarkar P, Dick AJ, et al., 2003, Magnetic resonance fluoroscopy-guided endovascular repair of abdominal aortic aneurysm in swine, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 428-428, ISSN: 0009-7322
De Silva R, Beatt KJ, 2002, Management of acute ST elevation myocardial infarction, Continuing Medical Education - Cardiology, Vol: 2, Pages: 44-57, ISSN: 1463-0486
This article reviews recent advances in the diagnosis and management of acute ST elevation myocardial infarction. Particular attention is paid to new developments in pharmacotherapy and the role of percutaneous coronary intervention. A suggested scheme for optimal management of acute STEMI on the basis of a review of the current literature is presented.
Rhodes CG, Rechavia E, de Silva R, 1998, F-18 FDG uptake in transplanted heart - Reply, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 31, Pages: 1441-1442, ISSN: 0735-1097
Camici PG, Wijns W, Borgers M, et al., 1997, Pathophysiological mechanisms of chronic reversible left ventricular dysfunction due to coronary artery disease (hibernating myocardium), CIRCULATION, Vol: 96, Pages: 3205-3214, ISSN: 0009-7322
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- Citations: 128
Rechavia E, deSilva R, Kushwaha SS, et al., 1997, Enhanced myocardial F-18-2-fluoro-2-deoxyglucose uptake after orthotopic heart transplantation assessed by positron emission tomography, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 30, Pages: 533-538, ISSN: 0735-1097
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- Citations: 23
Iida H, Rhodes CG, Araujo LI, et al., 1996, Noninvasive quantification of regional myocardial metabolic rate for oxygen by use of O-15(2) inhalation and positron emission tomography - Theory, error analysis, and application in humans, CIRCULATION, Vol: 94, Pages: 792-807, ISSN: 0009-7322
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- Citations: 60
Yamamoto Y, deSilva R, Rhodes CG, et al., 1996, Noninvasive quantification of regional myocardial metabolic rate of oxygen by O-15(2) inhalation and positron emission tomography - Experimental validation, CIRCULATION, Vol: 94, Pages: 808-816, ISSN: 0009-7322
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- Citations: 35
Rechavia E, DeSilva R, Nihoyannopoulos P, et al., 1995, Hyperdynamic performance of remote myocardium in acute infarction - Correlation between regional contractile function and myocardial perfusion, EUROPEAN HEART JOURNAL, Vol: 16, Pages: 1845-1850, ISSN: 0195-668X
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- Citations: 22
DESILVA R, CAMICI PG, 1994, ROLE OF POSITRON EMISSION TOMOGRAPHY IN THE INVESTIGATION OF HUMAN CORONARY CIRCULATORY FUNCTION, CARDIOVASCULAR RESEARCH, Vol: 28, Pages: 1595-1612, ISSN: 0008-6363
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- Citations: 55
UREN NG, CRAKE T, LEFROY DC, et al., 1994, REDUCED CORONARY VASODILATOR FUNCTION IN INFARCTED AND NORMAL MYOCARDIUM AFTER MYOCARDIAL-INFARCTION, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 331, Pages: 222-227, ISSN: 0028-4793
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- Citations: 321
Uren NG, Crake T, Lefroy DC, et al., 1994, Reduced coronary vasodilator function in infarcted and normal myocardium after myocardial infarction., N Engl J Med, Vol: 331, Pages: 222-227, ISSN: 0028-4793
BACKGROUND: The ability of the coronary vascular bed to dilate and thus increase blood flow to the myocardium may be impaired in coronary artery disease, even in regions of myocardium supplied by an angiographically normal coronary artery. If this kind of vasomotor dysfunction was present or accentuated after acute myocardial infarction, it might influence the extent of ischemia and necrosis in areas not directly injured by the infarction. METHODS: We studied 13 patients (mean [+/- SD] age, 62 +/- 11 years) with single-vessel coronary artery disease after they had received thrombolytic therapy for myocardial infarction. Using positron-emission tomography (PET) with oxygen-15-labeled water, we measured regional myocardial blood flow under basal conditions and after the intravenous administration of dipyridamole (0.5 mg per kg of body weight over a period of four minutes) 8 +/- 3 days after infarction in all 13 patients (1-week study) and 6 +/- 2 months after infarction in 9 of the 13 (6-month study). On both occasions we measured blood flow both in the infarcted region and in a region of myocardium that was remote from the infarcted region and supplied by a normal artery. RESULTS: At the one-week PET study, the coronary vasodilator response (the ratio of the myocardial blood flow after the administration of dipyridamole to basal blood flow) was 1.12 +/- 0.50 in the infarct-related artery and 1.53 +/- 0.36 in the remote region (P = 0.015). At the six-month study, the coronary vasodilator response was 1.42 +/- 0.37 in the infarcted region and 2.19 +/- 0.69 in the remote region (P = 0.004 for the comparison with the infarcted region; P = 0.011 for the comparison with the remote region at the one-week study). The value in remote myocardium remained lower than that in similar regions in 10 control patients, who had single-vessel coronary artery disease but no evidence of myocardial infarction (3.17 +/- 0.72; P = 0.009). CONCLUSIONS: After acute myocardial infarction, ther
UREN NG, CRAKE T, WILLIAMS J, et al., 1994, THE DISCUSSION OF MICROVASCULAR AND MYOCARDIAL STUNNING AFTER ACUTE MYOCARDIAL-INFARCTION, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Pages: A363-A363, ISSN: 0735-1097
LEFROY DC, DESILVA R, CHOUDHURY L, et al., 1993, DIFFUSE REDUCTION OF MYOCARDIAL BETA-ADRENOCEPTORS IN HYPERTROPHIC CARDIOMYOPATHY - A STUDY WITH POSITRON EMISSION TOMOGRAPHY, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 22, Pages: 1653-1660, ISSN: 0735-1097
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- Citations: 70
UREN NG, MARRACCINI P, GISTRI R, et al., 1993, ALTERED CORONARY VASODILATOR RESERVE AND METABOLISM IN MYOCARDIUM SUBTENDED BY NORMAL ARTERIES IN PATIENTS WITH CORONARY-ARTERY DISEASE, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 22, Pages: 650-658, ISSN: 0735-1097
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- Citations: 163
UEKI J, RHODES CG, HUGHES JMB, et al., 1993, IN-VIVO QUANTIFICATION OF PULMONARY BETA-ADRENOCEPTOR DENSITY IN HUMANS WITH (S)-[C-11]CGP-12177 AND PET, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 75, Pages: 559-565, ISSN: 8750-7587
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- Citations: 38
UREN NG, CRAKE T, LEFROY DC, et al., 1993, DELAYED RECOVERY OF CORONARY RESISTIVE VESSEL FUNCTION AFTER CORONARY ANGIOPLASTY, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 21, Pages: 612-621, ISSN: 0735-1097
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- Citations: 147
Uren NG, Crake T, Lefroy DC, et al., 1993, Delayed recovery of coronary resistive vessel function after coronary angioplasty., J Am Coll Cardiol, Vol: 21, Pages: 612-621, ISSN: 0735-1097
OBJECTIVES: The aim of this study was to use Doppler catheterization and sequential dynamic positron emission tomography (PET) to investigate the role and time course of abnormal coronary resistive vessel function in the impairment of the coronary vasodilator response (maximal/basal coronary blood flow) after successful coronary angioplasty. BACKGROUND: The coronary vasodilator response may be impaired immediately after coronary angioplasty, despite successful dilation of a flow-limiting stenosis. METHODS: Twelve men (mean age 52 +/- 10 years) with single-vessel coronary artery disease and normal left ventricular function were studied. The coronary vasodilator response to intravenous dipyridamole (0.5 mg.kg-1 over 4 min) was determined from intracoronary Doppler measurement of coronary flow velocity, before and after successful angioplasty. Basal and maximal myocardial blood flow in the angioplasty region and a normal region were determined in nine patients wtih positron emission tomography with H2(15)0 at 1 day (PET1), 7 days (PET2) and 3 months (PET3) after angioplasty. RESULTS: The coronary vasodilator response, measured by Doppler catheterization, was similar before and immediately after angioplasty, 1.63 +/- 0.41 and 1.62 +/- 0.55, respectively (p = NS). After angioplasty, in seven of nine patients without restenosis, basal myocardial blood flow at PET1, PET2 and PET3 was 0.98 +/- 0.16, 0.94 +/- 0.09 and 0.99 +/- 0.13 ml.min-1 x g-1, respectively, in the remote region and 1.19 +/- 0.23 (p < 0.01 vs. remote region), 1.17 +/- 0.19 (p < 0.01 vs. remote region) and 1.10 +/- 0.08 ml.min-1 x g-1 (p = NS vs. remote region), respectively, in the angioplasty region. Myocardial blood flow after dipyridamole at PET1, PET2 and PET3 was 3.04 +/- 0.68, 3.00 +/- 0.71 and 3.00 +/- 0.60 ml.min-1 x g-1, respectively, in the remote region and 2.11 +/- 0.80 (p < 0.01 vs. remote region), 2.28 +/- 0.73 (p = NS vs. remote region) and 3.06 +/- 0.86 ml.min-1 x g-1 (p = NS vs.
Yamamoto Y, Nonogi H, Iida H, et al., 1993, [Quantitative analysis of reperfusion therapy for acute myocardial infarction using positron emission tomography]., Jpn Circ J, Vol: 57 Suppl 4, Pages: 1358-1360, ISSN: 0047-1828
DESILVA R, CAMICI PG, 1992, ASSESSMENT OF MYOCARDIAL PERFUSION, METABOLISM AND PHARMACOLOGY USING POSITRON EMISSION TOMOGRAPHY, CARDIOSCIENCE, Vol: 3, Pages: 205-216, ISSN: 1015-5007
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- Citations: 4
DESILVA R, YAMAMOTO Y, RHODES CG, et al., 1992, PREOPERATIVE PREDICTION OF THE OUTCOME OF CORONARY REVASCULARIZATION USING POSITRON EMISSION TOMOGRAPHY, CIRCULATION, Vol: 86, Pages: 1738-1742, ISSN: 0009-7322
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- Citations: 104
SANDERS A, DESILVA R, MYERS R, et al., 1992, ISCHEMIA AND REPERFUSION INDUCED CHANGES IN RAT MYOCARDIAL PERIPHERAL TYPE BENZODIAZEPINE RECEPTORS, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 107, Pages: P95-P95, ISSN: 0007-1188
DESILVA R, CHOUDHURY L, LEFROY DC, et al., 1992, NONINVASIVE REGIONAL ASSESSMENT OF HUMAN CARDIAC BETA-ADRENOCEPTORS (BAR), CIRCULATION, Vol: 86, Pages: 298-298, ISSN: 0009-7322
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- Citations: 1
UREN NG, CRAKE T, LEFROY DC, et al., 1992, RECOVERY OF CORONARY RESISTIVE VESSEL DYSFUNCTION AFTER CORONARY ANGIOPLASTY, CIRCULATION, Vol: 86, Pages: 845-845, ISSN: 0009-7322
LEFROY DC, DESILVA R, CHOUDHURY L, et al., 1992, MYOCARDIAL BETA-ADRENOCEPTOR DENSITY IS REDUCED IN HYPERTROPHIC CARDIOMYOPATHY, CIRCULATION, Vol: 86, Pages: 246-246, ISSN: 0009-7322
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- Citations: 1
IIDA H, RHODES CG, DESILVA R, et al., 1992, USE OF THE LEFT-VENTRICULAR TIME-ACTIVITY CURVE AS A NONINVASIVE INPUT FUNCTION IN DYNAMIC OXYGEN-15-WATER POSITRON EMISSION TOMOGRAPHY, JOURNAL OF NUCLEAR MEDICINE, Vol: 33, Pages: 1669-1677, ISSN: 0161-5505
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- Citations: 185
Iida H, Rhodes CG, de Silva R, et al., 1992, Use of the left ventricular time-activity curve as a noninvasive input function in dynamic oxygen-15-water positron emission tomography., J Nucl Med, Vol: 33, Pages: 1669-1677, ISSN: 0161-5505
Noninvasive recording of arterial input functions using regions of interest (ROIs) in the left ventricular (LV) chamber obviates the need for arterial cannulation in PET, but it is compromised by the limited recovery coefficient of the LV chamber and by statistical noise. In the present study, a new mathematical model has been developed, which corrects for the spillover of radioactivity both from the myocardium into the LV ROI and the blood into the myocardial ROI. The method requires the measurement of a time-activity curve in the LV chamber during the dynamic H2(15)O PET study and the measurement of the recovery coefficient of the LV ROI using a 15O-carbon monoxide (C15O) scan and venous blood sampling. This approach was successfully validated against direct measurements of the arterial input function using an on-line beta detector in five greyhounds undergoing dynamic H2(15)O PET imaging. This technique also yielded myocardial blood flow (MBF) values which were not significantly different from those obtained with the beta-probe analyses (maximum difference less than 2%), provided that the LV ROIs were sufficiently large to provide good counting statistics. When this model was not applied for large ROIs (small recovery in LV ROI), systematic overestimations in MBF compared with beta-probe analysis (e.g., a factor by 40% for a recovery coefficient of 0.7) were observed. Thus, this technique enabled the prediction of an accurate input function using the LV time-activity curve, and hence, noninvasive quantification of MBF without arterial cannulation.
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