Publications
155 results found
Verheye S, Jolicoeur EM, Behan MW, et al., 2015, Efficacy of a device to narrow the coronary sinus in refractory angina, New England Journal of Medicine, Vol: 372, Pages: 519-527, ISSN: 0028-4793
BACKGROUNDMany patients with coronary artery disease who are not candidates for revascularization have refractory angina despite standard medical therapy. The balloon-expandable, stainless steel, hourglass-shaped, coronary-sinus reducing device creates a focal narrowing and increases pressure in the coronary sinus, thus redistributing blood into ischemic myocardium.METHODSWe randomly assigned 104 patients with Canadian Cardiovascular Society (CCS) class III or IV angina (on a scale from I to IV, with higher classes indicating greater limitations on physical activity owing to angina) and myocardial ischemia, who were not candidates for revascularization, to implantation of the device (treatment group) or to a sham procedure (control group). The primary end point was the proportion of patients with an improvement of at least two CCS angina classes at 6 months.RESULTSA total of 35% of the patients in the treatment group (18 of 52 patients), as compared with 15% of those in the control group (8 of 52), had an improvement of at least two CCS angina classes at 6 months (P=0.02). The device was also associated with improvement of at least one CCS angina class in 71% of the patients in the treatment group (37 of 52 patients), as compared with 42% of those in the control group (22 of 52) (P=0.003). Quality of life as assessed with the use of the Seattle Angina Questionnaire was significantly improved in the treatment group, as compared with the control group (improvement on a 100-point scale, 17.6 vs. 7.6 points; P=0.03). There were no significant between-group differences in improvement in exercise time or in the mean change in the wall-motion index as assessed by means of dobutamine echocardiography. At 6 months, 1 patient in the treatment group had had a myocardial infarction; in the control group, 1 patient had died and 3 had had a myocardial infarction.CONCLUSIONSIn this small clinical trial, implantation of the coronary-sinus reducing device was associated with signifi
Raphael CE, Hsu LY, Greve AM, et al., 2015, Wave intensity analysis and assessment of myocardial perfusion abnormalities in patients with hypertrophic cardiomyopathy, Journal of Cardiovascular Magnetic Resonance, Vol: 17, ISSN: 1097-6647
Keegan J, Raphael CE, Simpson R, et al., 2015, Validation of high temporal resolution spiral phase velocity mapping of coronary artery blood flow against Doppler flow wire, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647
Smith EJ, Di Mario C, Spratt JC, et al., 2015, Subintimal TRAnscatheter Withdrawal (STRAW) of Hematomas Compressing the Distal True Lumen: A Novel Technique to Facilitate Distal Reentry During Recanalization of Chronic Total Occlusion (CTO), JOURNAL OF INVASIVE CARDIOLOGY, Vol: 27, Pages: E1-E4, ISSN: 1042-3931
- Author Web Link
- Cite
- Citations: 18
McGill L-A, Scott AD, Ferreira PF, et al., 2015, Heterogeneity of fractional anisotropy and mean diffusivity measurements by in vivo diffusion tensor imaging in normal human hearts, PloS one, Vol: 10, Pages: e0132360-e0132360
de Silva R, Patel H, Hayward C, 2015, An approach to diagnosis and management of resistant hypertension, Journal of the Practice of Cardiovascular Sciences, Vol: 1, Pages: 60-60, ISSN: 2395-5414
Raval AN, Schmuck EG, Tefera G, et al., 2014, Bilateral administration of autologous CD133+cells in ambulatory patients with refractory critical limb ischemia: lessons learned from a pilot randomized, double-blind, placebo-controlled trial, CYTOTHERAPY, Vol: 16, Pages: 1720-1732, ISSN: 1465-3249
- Author Web Link
- Cite
- Citations: 35
Ferreira PF, Kilner PJ, McGill L-A, et al., 2014, In vivo cardiovascular magnetic resonance diffusion tensor imaging shows evidence of abnormal myocardial laminar orientations and mobility in hypertrophic cardiomyopathy, Journal of Cardiovascular Magnetic Resonance, Vol: 16, Pages: 1-16, ISSN: 1097-6647
BackgroundCardiac diffusion tensor imaging (cDTI) measures the magnitudes and directions of intramyocardial water diffusion. Assuming the cross-myocyte components to be constrained by the laminar microstructures of myocardium, we hypothesized that cDTI at two cardiac phases might identify any abnormalities of laminar orientation and mobility in hypertrophic cardiomyopathy (HCM).MethodsWe performed cDTI in vivo at 3 Tesla at end-systole and late diastole in 11 healthy controls and 11 patients with HCM, as well as late gadolinium enhancement (LGE) for detection of regional fibrosis.ResultsVoxel-wise analysis of diffusion tensors relative to left ventricular coordinates showed expected transmural changes of myocardial helix-angle, with no significant differences between phases or between HCM and control groups. In controls, the angle of the second eigenvector of diffusion (E2A) relative to the local wall tangent plane was larger in systole than diastole, in accord with previously reported changes of laminar orientation. HCM hearts showed higher than normal global E2A in systole (63.9° vs 56.4° controls, p =0.026) and markedly raised E2A in diastole (46.8° vs 24.0° controls, p < 0.001). In hypertrophic regions, E2A retained a high, systole-like angulation even in diastole, independent of LGE, while regions of normal wall thickness did not (LGE present 57.8°, p =0.0028, LGE absent 54.8°, p =0.0022 vs normal thickness 38.1°).ConclusionsIn healthy controls, the angles of cross-myocyte components of diffusion were consistent with previously reported transmural orientations of laminar microstructures and their changes with contraction. In HCM, especially in hypertrophic regions, they were consistent with hypercontraction in systole and failure of relaxation in diastole. Further investigation of this finding is required as previously postulated effects of strain might be a confounding factor.
Pedrigi RM, de Silva R, Bovens SM, et al., 2014, Thin-Cap Fibroatheroma Rupture Is Associated With a Fine Interplay of Shear and Wall Stress, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 34, Pages: 2224-2231, ISSN: 1079-5642
- Author Web Link
- Cite
- Citations: 41
Nielles-Vallespin S, Mekkaoui C, Gatehouse P, et al., 2014, In Vivo Diffusion Tensor MRI of the Human Heart: Reproducibility of Breath-Hold and Navigator Based Approaches (vol 70, pg 454, 2013), MAGNETIC RESONANCE IN MEDICINE, Vol: 72, Pages: 599-599, ISSN: 0740-3194
- Author Web Link
- Cite
- Citations: 5
Steg PG, De Silva R, 2014, Beta-Blockers in Asymptomatic Coronary Artery Disease No Benefit or No Evidence?, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 64, Pages: 253-255, ISSN: 0735-1097
- Author Web Link
- Cite
- Citations: 11
Zivelonghi C, Ghione M, Kilickesmez K, et al., 2014, Intracoronary optical coherence tomography: a review of clinical applications, JOURNAL OF CARDIOVASCULAR MEDICINE, Vol: 15, Pages: 543-553, ISSN: 1558-2027
- Author Web Link
- Cite
- Citations: 7
Mattesini A, Secco GG, Dall'Ara G, et al., 2014, ABSORB Biodegradable Stents Versus Second-Generation Metal Stents, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 7, Pages: 741-750, ISSN: 1936-8798
- Author Web Link
- Cite
- Citations: 105
Kilickesmez K, Dall'Ara G, Rama-Merchan JC, et al., 2014, Optical coherence tomography characteristics of in-stent restenosis are different between first and second generation drug eluting stents., Int J Cardiol Heart Vessel, Vol: 3, Pages: 68-74
AIMS: Characterization of neointimal tissue is essential to understand the pathophysiology of in-stent restenosis (ISR) after drug eluting stent (DES) implantation. Using optical coherence tomography (OCT), we compared the morphologic characteristics of ISR between first and second generation DES. METHODS AND RESULTS: OCT was performed in 66 DES-ISR, defined as > 50% angiographic diameter stenosis within the stented segment. Patients with ISR of first generation sirolimus-eluting stents (SES), paclitaxel eluting stents (PES) and second generation zotarolimus-eluting stents (ZES), everolimus-eluting stents (EES) and biolimus-eluting stents (BES) were enrolled. Quantitative and qualitative ISR tissue analysis was performed at 1-mm intervals along the entire stent, and categorised as homogeneous, heterogeneous and neo-atherosclerosis. The presence of microvessels and peri-strut low intensity area (PSLIA) was determined in all ISR. Neoatherosclerosis was identified by lipid, calcium and thin-cap fibro-atheroma (TCFA) like lesions. We compared the two DES generations at both early (< 1 year) and late (> 1 year) follow-ups.In second generation DES a heterogeneous pattern was prevalent both before and after 1 year (57.1% and 58.6% respectively). Neo-atherosclerosis was more common in the early period in first generation DES (19.4% vs 11.7%, p < 0.01), but after one year was more prevalent in second generation DES (7.0% vs 19.3%, p < 0.01). Similar prevalence of TCFAs was observed in both groups in all comparisons. CONCLUSIONS: When ISR restenosis occurs in second generation DES, the current data suggest a different time course and different morphological characteristics from first generation. Future prospective studies should evaluate the relationship between ISR morphology, time course and clinical events.
Ghione M, Kýlýçkesmez K, Zivelonghi C, et al., 2013, Intracoronary Optical Coherence Tomography: Experience and Indications for Clinical Use, Current Cardiovascular Imaging Reports, Vol: 6, Pages: 399-410, ISSN: 1941-9066
Optical coherence tomography (OCT) is a light based technology that provides very high spatial resolution images. OCT has been initially employed as a research tool to investigate plaque morphology and stent strut coverage. The introduction of frequency domain OCT, allowing fast image acquisition during a prolonged contrast injection via the guiding catheter, has made OCT applicable for guidance of coronary interventions. In this manuscript the various applications of OCT are reviewed, from assessment of plaque vulnerability and severity to characteristics of unstable lesions and thrombus burden to stent optimization and evaluation of late results. © 2013 Springer Science+Business Media New York.
McGill L-A, Ismail T, Nielles-Vallespin S, et al., 2013, reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy (vol 14, pg 86, 2012), JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 15, ISSN: 1097-6647
- Author Web Link
- Cite
- Citations: 2
McGill LA, Ismail T, Nielles-Vallespin S, et al., 2013, Correction: reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy., J Cardiovasc Magn Reson, Vol: 15
Ferreira PF, Nielles-Vallespin S, Gatehouse PD, et al., 2013, Cardiac diffusion tensor imaging: helix angle (HA) healthy statistical average technique for HA quantification in vivo, Journal of Cardiovascular Magnetic Resonance, Vol: 15, Pages: W7-W7
Ferreira PF, Nielles-Vallespin S, Gatehouse PD, et al., 2013, Improved navigator based diffusion tensor MRI of the human heart in vivo, Journal of Cardiovascular Magnetic Resonance, Vol: 15, Pages: W25-W25
Nielles-Vallespin S, Mekkaoui C, Gatehouse P, et al., 2013, In vivo diffusion tensor MRI of the human heart: Reproducibility of breath-hold and navigator-based approaches, Magnetic resonance in medicine, Vol: 70, Pages: 454-465
Tung K-P, Bei W-J, Shi W-Z, et al., 2013, MULTI-ATLAS BASED NEOINTIMA SEGMENTATION IN INTRAVASCULAR CORONARY OCT, IEEE 10th International Symposium on Biomedical Imaging - From Nano to Macro (ISBI), Publisher: IEEE, Pages: 1280-1283, ISSN: 1945-7928
- Author Web Link
- Cite
- Citations: 1
McGill L-A, Ismail TF, Nielles-Vallespin S, et al., 2012, Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy, Journal of Cardiovascular Magnetic Resonance, Vol: 14, Pages: 86-86, ISSN: 1097-6647
Background: Myocardial disarray is an important histological feature of hypertrophic cardiomyopathy (HCM) whichhas been studied post-mortem, but its in-vivo prevalence and extent is unknown. Cardiac Diffusion Tensor Imaging(cDTI) provides information on mean intravoxel myocyte orientation and potentially myocardial disarray. Recenttechnical advances have improved in-vivo cDTI, and the aim of this study was to assess the interstudyreproducibility of quantitative in-vivo cDTI in patients with HCM.Methods and results: A stimulated-echo single-shot-EPI sequence with zonal excitation and parallel imaging wasimplemented. Ten patients with HCM were each scanned on 2 different days. For each scan 3 short axismid-ventricular slices were acquired with cDTI at end systole. Fractional anisotropy (FA), mean diffusivity (MD), andhelix angle (HA) maps were created using a cDTI post-processing platform developed in-house. The mean ± SDglobal FA was 0.613 ± 0.044, MD was 0.750 ± 0.154 × 10-3 mm2/s and HA was epicardium −34.3 ± 7.6°,mesocardium 3.5 ± 6.9° and endocardium 38.9 ± 8.1°. Comparison of initial and repeat studies showed globalinterstudy reproducibility for FA (SD = ± 0.045, Coefficient of Variation (CoV) = 7.2%), MD (SD = ± 0.135 × 10-3 mm2/s,CoV = 18.6%) and HA (epicardium SD = ± 4.8°; mesocardium SD = ± 3.4°; endocardium SD = ± 2.9°). Reproducibilityof FA was superior to MD (p = 0.003). Global MD was significantly higher in the septum than the reference lateralwall (0.784 ± 0.188 vs 0.750 ± 0.154 x10-3 mm2/s, p < 0.001). Septal HA was significantly lower than the referencelateral wall in all 3 transmural layers (from −8.3° to −10.4°, all p < 0.001).Conclusions: To the best of our knowledge, this is the first study to assess the interstudy reproducibility of DTI inthe human HCM heart in-vivo and the largest cDTI stu
De Silva R, Raval AN, Pepper JR, 2012, Stem Cells for Cardiac Repair, Tissue and Cell Clinical Use: An Essential Guide, Pages: 403-420, ISBN: 9781405198257
The heart shows inadequate ability to repair itself after myocardial infarction and other forms of heart disease, resulting in significant impairment of contractile function and adverse ventricular remodelling, which are the major determinants of adverse clinical outcome. Improvement of cardiac function through delivery of novel cellular therapies with the aim of replacing lost cells has therefore been a major strategic focus for the emerging field of regenerative medicine. This chapter will summarize some of the early clinical experiences with cardiovascular cell therapy and discuss the outstanding challenges to successful clinical translation of this novel therapeutic approach. © 2012 Blackwell Publishing Ltd.
Purcell H, De Silva R, 2012, Treating stable angina - is there a NICE way towards an international consensus?, INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol: 66, Pages: 614-618, ISSN: 1368-5031
Alegria-Barrero E, Foin N, Chan PH, et al., 2012, Optical coherence tomography for guidance of distal cell recrossing in bifurcation stenting: choosing the right cell matters, EUROINTERVENTION, Vol: 8, Pages: 205-213, ISSN: 1774-024X
- Author Web Link
- Cite
- Citations: 63
Luis Gutierrez-Chico J, Alegria-Barrero E, Teijeiro-Mestre R, et al., 2012, Optical coherence tomography: from research to practice, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 13, Pages: 370-384, ISSN: 2047-2404
- Author Web Link
- Cite
- Citations: 60
Tearney GJ, Regar E, Akasaka T, et al., 2012, Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation., J Am Coll Cardiol, Vol: 59, Pages: 1058-1072
OBJECTIVES: The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the diagnosis and treatment of patients with atherosclerosis, including coronary artery disease. BACKGROUND: Intravascular optical coherence tomography (IVOCT) is a catheter-based modality that acquires images at a resolution of ~10 μm, enabling visualization of blood vessel wall microstructure in vivo at an unprecedented level of detail. IVOCT devices are now commercially available worldwide, there is an active user base, and the interest in using this technology is growing. Incorporation of IVOCT in research and daily clinical practice can be facilitated by the development of uniform terminology and consensus-based standards on use of the technology, interpretation of the images, and reporting of IVOCT results. METHODS: The IWG-IVOCT, comprising more than 260 academic and industry members from Asia, Europe, and the United States, formed in 2008 and convened on the topic of IVOCT standardization through a series of 9 national and international meetings. RESULTS: Knowledge and recommendations from this group on key areas within the IVOCT field were assembled to generate this consensus document, authored by the Writing Committee, composed of academicians who have participated in meetings and/or writing of the text. CONCLUSIONS: This document may be broadly used as a standard reference regarding the current state of the IVOCT imaging modality, intended for researchers and clinicians who use IVOCT and analyze IVOCT data.
Tung KP, Shi WZ, Pizarro L, et al., 2012, Automatic Detection of Coronary Stent Struts in Intravascular OCT imaging, Conference on Medical Imaging - Computer-Aided Diagnosis, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
- Author Web Link
- Cite
- Citations: 5
Ehret GB, Munroe PB, Rice KM, et al., 2011, Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk, NATURE, Vol: 478, Pages: 103-109, ISSN: 0028-0836
- Author Web Link
- Open Access Link
- Cite
- Citations: 1509
Li X, Johnson KR, Bryant M, et al., 2011, Intranasal Delivery of E-Selectin Reduces Atherosclerosis in ApoE-/- Mice, PLOS ONE, Vol: 6, ISSN: 1932-6203
- Author Web Link
- Cite
- Citations: 6
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.